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Select item 98519731.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81436483.

Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents

Sung-Soo Park, Daniela Ponce-Balbuena, Rork Kuick, Guadalupe Guerrero-Serna, Justin Yoon, Dattatreya Mellacheruvu, Kevin P. Conlon, Venkatesha Basrur, Alexey I. Nesvizhskii, José Jalife, Jean-François Rual

Mol Cell Proteomics. 2020 Sep; 19(9): 1436–1449. Published online 2020 Nov 25. doi: 10.1074/mcp.RA120.002071

PMCID:: PMC8143648

Abstract Article PDF–3.9M

Select item 71699834.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 63901105.

Kir2.2 p.Thr140Met: a genetic susceptibility to sporadic periodic paralysis

CHUNXIANG FAN, MARIUS KUHN, ALEXANDER PEPLER MBIOL, JAMES GROOME, VERN WINSTON, SASKIA BISKUP, FRANK LEHMANN-HORN, KARIN JURKAT-ROTT

Acta Myol. 2018 Sep; 37(3): 193–203. Published online 2018 Sep 1.

PMCID:: PMC6390110

Abstract Article PDF–281K

Select item 61007246.

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Gustav N Sundell, Roland Arnold, Muhammad Ali, Piangfan Naksukpaiboon, Julien Orts, Peter Güntert, Celestine N Chi, Ylva Ivarsson

Mol Syst Biol. 2018 Aug; 14(8): e8129. Published online 2018 Aug 20. doi: 10.15252/msb.20178129

PMCID:: PMC6100724

Abstract Article PDF–2.4M

Select item 57714207.

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje cell-Dependent Ventricular Arrhythmias

Ravi Vaidyanathan, Hanora Van Ert, Kazi T Haq, Stefano Morotti, Samuel Esch, Elise C. McCune, Eleonora Grandi, Lee L. Eckhardt

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2018 Jan; 11(1): e005800. doi: 10.1161/CIRCEP.117.005800

PMCID:: PMC5771420

Abstract Article PDF–1.1M

Select item 55716868.

Whole exome sequencing identifies a KCNJ12 mutation as a cause of familial dilated cardiomyopathy

Hai-Xin Yuan, Kai Yan, Dong-Yan Hou, Zhi-Yong Zhang, Hua Wang, Xin Wang, Juan Zhang, Xiao-Rong Xu, Yan-Hong Liang, Wen-Shu Zhao, Lin Xu, Lin Zhang

Medicine (Baltimore) 2017 Aug; 96(33): e7727. Published online 2017 Aug 18. doi: 10.1097/MD.0000000000007727

PMCID:: PMC5571686

Abstract Article PDF–266K

Select item 50859999.

Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels

Shouqin Lü, Hailong An, Hailin Zhang, Mian Long

Mol Neurobiol. 2016; 53(9): 5948–5961. Published online 2015 Oct 31. doi: 10.1007/s12035-015-9466-x

PMCID:: PMC5085999

Abstract Article PDF–6.0M

Select item 483662510.

Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels

Marcos Matamoros, Marta Pérez-Hernández, Guadalupe Guerrero-Serna, Irene Amorós, Adriana Barana, Mercedes Núñez, Daniela Ponce-Balbuena, Sandra Sacristán, Ricardo Gómez, Juan Tamargo, Ricardo Caballero, José Jalife, Eva Delpón

Cardiovasc Res. 2016 May 15; 110(2): 279–290. Published online 2016 Jan 19. doi: 10.1093/cvr/cvw009

PMCID:: PMC4836625

Abstract Article PDF–1.0M

Select item 471744211.

Rare KCNJ18 variants do not explain hypokalaemic periodic paralysis in 263 unrelated patients

Marius Kuhn, Karin Jurkat-Rott, Frank Lehmann-Horn

J Neurol Neurosurg Psychiatry. 2016 Jan; 87(1): 49–52. Published online 2015 Apr 16. doi: 10.1136/jnnp-2014-309293

PMCID:: PMC4717442

Abstract Article PDF–319K

Select item 437180712.

The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis

Xiaobing Li, Sheng Yao, Yining Xiang, Xiaolei Zhang, Xiangbing Wu, Laimin Luo, Haihua Huang, Min Zhu, Hui Wan, Daojun Hong

BMC Neurol. 2015; 15: 38. Published online 2015 Mar 21. doi: 10.1186/s12883-015-0290-8

PMCID:: PMC4371807

Abstract Article PDF–363K

Select item 393293313.

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Ylva Ivarsson, Roland Arnold, Megan McLaughlin, Satra Nim, Rakesh Joshi, Debashish Ray, Bernard Liu, Joan Teyra, Tony Pawson, Jason Moffat, Shawn Shun-Cheng Li, Sachdev S. Sidhu, Philip M. Kim

Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7): 2542–2547. Published online 2014 Feb 3. doi: 10.1073/pnas.1312296111

PMCID:: PMC3932933

Abstract Article PDF–1.0M

Select item 376663114.

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

Weizhen Ji, Jia Nee Foo, Brian J. O'Roak, Hongyu Zhao, Martin G. Larson, David B. Simon, Christopher Newton-Cheh, Matthew W. State, Daniel Levy, Richard P. Lifton

Nat Genet. Author manuscript; available in PMC 2013 Sep 8.

Published in final edited form as: Nat Genet. 2008 May; 40(5): 592–599. Published online 2008 Apr 6. doi: 10.1038/ng.118