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Select item 85269261.

Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies

Rongguo Yu, Jiayu Zhang, Youguang Zhuo, Xu Hong, Jie Ye, Susu Tang, Yiyuan Zhang

Front Immunol. 2021; 12: 724934. Published online 2021 Oct 6. doi: 10.3389/fimmu.2021.724934

PMCID:: PMC8526926

Abstract Article PDF–3.8M

Select item 83950392.

Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis

Reiner Noschka, Fanny Wondany, Gönül Kizilsavas, Tanja Weil, Gilbert Weidinger, Paul Walther, Jens Michaelis, Steffen Stenger

Int J Mol Sci. 2021 Aug; 22(16): 8392. Published online 2021 Aug 4. doi: 10.3390/ijms22168392

PMCID:: PMC8395039

Abstract Article PDF–5.9M

Select item 81700933.

A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin

Maria Andrea Hernández-Castañeda, Marilyne Lavergne, Pierina Casanova, Bryan Nydegger, Carla Merten, Bibin Yesodha Subramanian, Patricia Matthey, Nils Lannes, Pierre-Yves Mantel, Michael Walch

Front Immunol. 2021; 12: 643746. Published online 2021 May 19. doi: 10.3389/fimmu.2021.643746

PMCID:: PMC8170093

Abstract Article PDF–5.2M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78767485.

The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Michael Sadek, Omer Iqbal, Fakiha Siddiqui, Sean Till, Melissa Mazariegos, Edward Campbell, Kumaran Mudaliar, Jodi Speiser, Emily Bontekoe, Ahmed Kouta, Ambar Farooqui, Bharathi Daravath, Dalia Qneibi, Ramy Sadek, Debra Hoppensteadt, Jawed Fareed, Charles Bouchard

Clin Appl Thromb Hemost. 2021 Jan-Dec; 27: 1076029620950831. Published online 2021 Feb 9. doi: 10.1177/1076029620950831

PMCID:: PMC7876748

Abstract Article PDF–888K

Select item 74841796.

Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts

Ângela C. Crespo, Sachin Mulik, Farokh Dotiwala, James A. Ansara, Sumit Sen Santara, Kayleigh Ingersoll, Cristian Ovies, Caroline Junqueira, Tamara Tilburgs, Jack L. Strominger, Judy Lieberman

Cell. Author manuscript; available in PMC 2021 Sep 3.

Published in final edited form as: Cell. 2020 Sep 3; 182(5): 1125–1139.e18. Published online 2020 Aug 20. doi: 10.1016/j.cell.2020.07.019

PMCID:: PMC7484179

Abstract Article PDF–3.3M

Select item 74829707.

Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage

Natália Satchiko Hojo-Souza, Patrick Orestes de Azevedo, Júlia Teixeira de Castro, Andréa Teixeira-Carvalho, Judy Lieberman, Caroline Junqueira, Ricardo Tostes Gazzinelli

PLoS Pathog. 2020 Sep; 16(9): e1008840. Published online 2020 Sep 10. doi: 10.1371/journal.ppat.1008840

PMCID:: PMC7482970

Abstract Article PDF–4.9M

Select item 74814128.

Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery

Ling Hao, Jilei Ma, Chunwei Shi, Xiaosong Lin, Yandi Zhang, Banga Ndzouboukou Jo-Lewis, Qing Lei, Nadeem Ullah, Zhongjie Yao, Xionglin Fan

Theranostics. 2020; 10(22): 10046–10056. Published online 2020 Aug 8. doi: 10.7150/thno.48052

PMCID:: PMC7481412

Abstract Article PDF–2.1M

Select item 73252799.

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

Farokh Dotiwala, Sachin Mulik, Rafael B Polidoro, James A Ansara, Barbara A Burleigh, Michael Walch, Ricardo T Gazzinelli, Judy Lieberman

Nat Med. Author manuscript; available in PMC 2020 Jun 30.

Published in final edited form as: Nat Med. 2016 Feb; 22(2): 210–216. Published online 2016 Jan 11. doi: 10.1038/nm.4023

PMCID:: PMC7325279

Abstract Article PDF–1.6M

Select item 730286910.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

Caroline Boulouis, Wan Rong Sia, Muhammad Yaaseen Gulam, Jocelyn Qi Min Teo, Yi Tian Png, Thanh Kha Phan, Jeffrey Y. W. Mak, David P. Fairlie, Ivan K. H. Poon, Tse Hsien Koh, Peter Bergman, Chwee Ming Lim, Lin-Fa Wang, Andrea Lay Hoon Kwa, Johan K. Sandberg, Edwin Leeansyah

PLoS Biol. 2020 Jun; 18(6): e3000644. Published online 2020 Jun 8. doi: 10.1371/journal.pbio.3000644

PMCID:: PMC7302869

Abstract Article PDF–3.5M

Select item 716998311.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 708638812.

γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage

Maria Andrea Hernández-Castañeda, Katharina Happ, Filippo Cattalani, Alexandra Wallimann, Marianne Blanchard, Isabelle Fellay, Brigitte Scolari, Nils Lannes, Smart Mbagwu, Benoît Fellay, Luis Filgueira, Pierre-Yves Mantel, Michael Walch

J Immunol. 2020 Apr 1; 204(7): 1798–1809. Published online 2020 Feb 17. doi: 10.4049/jimmunol.1900725

PMCID:: PMC7086388

Abstract Article PDF–2.5M

Select item 695952513.

Granulysin Production and Anticryptococcal Activity Is Dependent upon a Far Upstream Enhancer That Binds STAT5 in Human Peripheral Blood CD4⁺ T Cells

Junji Xing, Fuqing Wu, Shuai Wang, Alan M. Krensky, Christopher H. Mody, Chunfu Zheng

J Immunol. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: J Immunol. 2010 Nov 1; 185(9): 5074–5081. Published online 2010 Oct 1. doi: 10.4049/jimmunol.1001725

PMCID:: PMC6959525

Abstract Article PDF–937K

Select item 695952314.

Granulysin Delivered by Cytotoxic Cells Damages Endoplasmic Reticulum and Activates Caspase-7 in Target Cells

Reena V. Saini, Christine Wilson, Michael W. Finn, Tianhong Wang, Alan M. Krensky, Carol Clayberger

J Immunol. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: J Immunol. 2011 Mar 15; 186(6): 3497–3504. Published online 2011 Feb 4. doi: 10.4049/jimmunol.1003409

PMCID:: PMC6959523

Abstract Article PDF–1.6M

Select item 626726615.

Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type

Giuseppe Lo Bello, Ayse U. Akarca, Maria Raffaella Ambrosio, Claudio Agostinelli, Hernan Molina-Kirsch, Alan Ramsay, Manuel Rodriguez-Justo, Matt Pugh, Shuchun Zhao, Monique DeLisser, Elena Sabattini, Stefan Dojcinov, Stefano A. Pileri, Yasodha Natkunam, Lorenzo Leoncini, Teresa Marafioti

Virchows Arch. 2018; 473(6): 749–757. Published online 2018 Aug 27. doi: 10.1007/s00428-018-2434-x

PMCID:: PMC6267266

Abstract Article PDF–8.4M

Select item 526093916.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 507018217.

Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays

Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien, Naoto Keicho

BMC Infect Dis. 2016; 16: 580. Published online 2016 Oct 18. doi: 10.1186/s12879-016-1911-6

PMCID:: PMC5070182

Abstract Article PDF–632K

Select item 489882318.

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin

Hung-Mu Wei, Li-Chih Lin, Chiu-Feng Wang, Yi-Jang Lee, Yuan-Tsong Chen, You-Di Liao

PLoS One. 2016; 11(6): e0156321. Published online 2016 Jun 8. doi: 10.1371/journal.pone.0156321

PMCID:: PMC4898823

Abstract Article PDF–12M

Select item 409091619.

Cytotoxic cells kill intracellular bacteria through Granulysin-mediated delivery of Granzymes

Michael Walch, Farokh Dotiwala, Sachin Mulik, Jerome Thiery, Tomas Kirchhausen, Carol Clayberger, Alan M. Krensky, Denis Martinvalet, Judy Lieberman

Cell. Author manuscript; available in PMC 2015 Jun 5.

Published in final edited form as: Cell. 2014 Jun 5; 157(6): 1309–1323. doi: 10.1016/j.cell.2014.03.062

Correction in:: volume 161 on page 1229

PMCID:: PMC4090916

Abstract Article PDF–2.7M

Select item 369179920.

Potential Function of Granulysin, Other Related Effector Molecules and Lymphocyte Subsets in Patients with TB and HIV/TB Coinfection

Nada Pitabut, Shinsaku Sakurada, Takahiro Tanaka, Chutharut Ridruechai, Junko Tanuma, Takahiro Aoki, Pacharee Kantipong, Surachai Piyaworawong, Nobuyuki Kobayashi, Panadda Dhepakson, Hideki Yanai, Norio Yamada, Shinichi Oka, Masaji Okada, Srisin Khusmith, Naoto Keicho

Int J Med Sci. 2013; 10(8): 1003–1014. Published online 2013 Jun 15. doi: 10.7150/ijms.6437

PMCID:: PMC3691799

Abstract Article PDF–1.0M

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