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Select item 110979051.

The brain insulin receptor gene network and associations with frailty index

Jannica S Selenius, Patricia P Silveira, Markus J Haapanen, Mikaela von Bonsdorff, Jari Lahti, Johan G Eriksson, Niko S Wasenius

Age Ageing. 2024 May; 53(5): afae091. Published online 2024 May 16. doi: 10.1093/ageing/afae091

PMCID:: PMC11097905

Abstract Article PDF–753K

Select item 109608142.

Activation of the insulin receptor by insulin-like growth factor 2

Weidong An, Catherine Hall, Jie Li, Albert Hung, Jiayi Wu, Junhee Park, Liwei Wang, Xiao-chen Bai, Eunhee Choi

Nat Commun. 2024; 15: 2609. Published online 2024 Mar 23. doi: 10.1038/s41467-024-46990-6

PMCID:: PMC10960814

Abstract Article PDF–5.6M

Select item 107354683.

Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH–IGF-1 Axis

Marinna C Okawa, Rebecca M Tuska, Marissa Lightbourne, Brent S Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J Brown

J Clin Endocrinol Metab. 2024 Jan; 109(1): e96–e106. Published online 2023 Aug 18. doi: 10.1210/clinem/dgad491

PMCID:: PMC10735468

Abstract Article

Select item 103988854.

Activation mechanism of the insulin receptor: a structural perspective

Eunhee Choi, Xiao-chen Bai

Annu Rev Biochem. Author manuscript; available in PMC 2023 Aug 3.

Published in final edited form as: Annu Rev Biochem. 2023 Jun 20; 92: 247–272. Published online 2023 Mar 31. doi: 10.1146/annurev-biochem-052521-033250

PMCID:: PMC10398885

Abstract Article PDF–2.7M

Select item 102760715.

Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study

Chenxi Qin, Lina-Marcela Diaz-Gallo, Bowen Tang, Yunzhang Wang, Thuy-Dung Nguyen, Arvid Harder, Yi Lu, Leonid Padyukov, Johan Askling, Sara Hägg

Eur J Epidemiol. 2023; 38(7): 809–819. Published online 2023 Apr 13. doi: 10.1007/s10654-023-01000-9

PMCID:: PMC10276071

Abstract Article PDF–1.0M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99891537.

Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes

Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xia

Exp Biol Med (Maywood) 2023 Jan; 248(1): 44–51. Published online 2022 Nov 20. doi: 10.1177/15353702221131886

PMCID:: PMC9989153

Abstract Article PDF–1.7M

Select item 99279348.

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling

Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn

J Clin Invest. 2023 Feb 15; 133(4): e161472. Published online 2023 Feb 15. doi: 10.1172/JCI161472

PMCID:: PMC9927934

Abstract Article PDF–2.8M

Select item 98160599.

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou

Oncogene. 2023; 42(2): 83–98. Published online 2022 Nov 12. doi: 10.1038/s41388-022-02537-x

PMCID:: PMC9816059

Abstract Article PDF–7.6M

Select item 981299210.

Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis

Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M. Dreyfuss, Thiago M. Batista, Bruna B. Brandão, Matthias Mann, C. Ronald Kahn

Nat Commun. 2023; 14: 57. Published online 2023 Jan 4. doi: 10.1038/s41467-022-35693-5

PMCID:: PMC9812992

Abstract Article PDF–5.6M

Select item 972703311.

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young

Nat Commun. 2022; 13: 7522. Published online 2022 Dec 6. doi: 10.1038/s41467-022-35176-7

PMCID:: PMC9727033

Abstract Article PDF–5.2M

Select item 954239712.

Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart

Mahmoud Abdellatif, Frank Madeo, Guido Kroemer, Simon Sedej

Autophagy. 2022; 18(10): 2500–2502. Published online 2022 Jul 10. doi: 10.1080/15548627.2022.2095835

PMCID:: PMC9542397

Abstract Article PDF–609K

Select item 943393813.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 938769614.

Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling

Dalia Walzer, Adina F Turcu, Smita Jha, Brent S Abel, Richard J Auchus, Deborah P Merke, Rebecca J Brown

J Clin Endocrinol Metab. 2022 Sep; 107(9): 2626–2635. Published online 2022 Jun 13. doi: 10.1210/clinem/dgac365

PMCID:: PMC9387696

Abstract Article

Select item 925585815.

Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia‐associated insulin resistance

Haoning Howard Cen, Bahira Hussein, José Diego Botezelli, Su Wang, Jiashuo Aaron Zhang, Nilou Noursadeghi, Niels Jessen, Brian Rodrigues, James A. Timmons, James D. Johnson

FASEB J. 2022 Jan; 36(1): e22088. Published online 2021 Dec 18. doi: 10.1096/fj.202100497RR

PMCID:: PMC9255858

Abstract Article PDF–6.1M

Select item 917141116.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 913487017.

Case Report: A Chinese Family of Type A Insulin Resistance Syndrome With Diabetes Mellitus, With a Novel Heterozygous Missense Mutation of the Insulin Receptor Gene

Wei You, Jianming Yang, Lu Wang, Yanqun Liu, Wen Wang, Li Zhu, Wei Wang, Jun Yang, Fangyuan Chen

Front Endocrinol (Lausanne) 2022; 13: 895424. Published online 2022 May 12. doi: 10.3389/fendo.2022.895424

PMCID:: PMC9134870

Abstract Article PDF–1.4M

Select item 910523518.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 900533219.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

Danielle L. Swaney, Dana J. Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael McGregor, Kari A. Herrington, Rachel O’Keefe, Nan Jin, Nathan K. VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F. Kreisberg, Minkyu Kim, Daniel E. Johnson, Natalia Jura, Jennifer R. Grandis, J. Silvio Gutkind, Trey Ideker, Nevan J. Krogan

Science. Author manuscript; available in PMC 2022 Apr 13.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf2911. Published online 2021 Oct 1. doi: 10.1126/science.abf2911

PMCID:: PMC9005332

Abstract Article PDF–2.0M

Select item 873281020.

Insulin and the insulin receptor collaborate to promote human gastric cancer

Marina Saisana, S. Michael Griffin, Felicity E. B. May

Gastric Cancer. 2022; 25(1): 107–123. Published online 2021 Sep 23. doi: 10.1007/s10120-021-01236-y

PMCID:: PMC8732810

Abstract Article PDF–12M

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