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Items: 1 to 20 of 30

1.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
2.
Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia
Adrien Georges, Juliette Albuisson, Takiy Berrandou, Délia Dupré, Aurélien Lorthioir, Valentina D’Escamard, Antonio F Di Narzo, Daniella Kadian-Dodov, Jeffrey W Olin, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz, Patrick Bruneval, Anna A Baranowska, Tom R Webb, Stephen E Hamby, Nilesh J Samani, David Adlam, Natalia Fendrikova-Mahlay, Stanley Hazen, Yu Wang, Min-Lee Yang, Kristina Hunker, Nicolas Combaret, Pascal Motreff, Antoine Chédid, Béatrice Fiquet, Pierre-François Plouin, Elie Mousseaux, Arshid Azarine, Laurence Amar, Michel Azizi, Heather L Gornik, Santhi K Ganesh, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Cardiovasc Res. 2021 Apr 1; 117(4): 1154–1165. Published online 2020 Jun 12. doi: 10.1093/cvr/cvaa161
PMCID:
PMC7983006
AbstractArticlePDF–1.4M
3.
Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner
Takahiro Osawa, Noritaka Ohga, Yasuhiro Hida, Kazuko Kitayama, Kosuke Akiyama, Yuichiro Onodera, Manabu Fujie, Nobuo Shinohara, Masanobu Shindoh, Katsuya Nonomura, Kyoko Hida
Cancer Sci. 2012 Jun; 103(6): 1038–1044. Published online 2012 Apr 17. doi: 10.1111/j.1349-7006.2012.02261.x
PMCID:
PMC7685074
AbstractArticlePDF–510K
4.
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik
Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.
Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834
PMCID:
PMC5557292
AbstractArticlePDF–3.4M
5.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
6.
Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels
Tongrong He, Anantha Vijay R Santhanam, Tong Lu, Livius V d'Uscio, Zvonimir S Katusic
J Cereb Blood Flow Metab. 2017 Jan; 37(1): 106–122. Published online 2015 Nov 20. doi: 10.1177/0271678X15618977
PMCID:
PMC5363732
AbstractArticlePDF–1.0M
7.
High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function
Anke Bill, Elizabeth M. Rosethorne, Toby C. Kent, Lindsay Fawcett, Lynn Burchell, Michiel T. van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P. Orth, Nicole A. Renaud, Steven J. Charlton, Martin Gosling, L. Alex Gaither, Paul J. Groot-Kormelink
PLoS One. 2014; 9(6): e97973. Published online 2014 Jun 2. doi: 10.1371/journal.pone.0097973
PMCID:
PMC4041722
AbstractArticlePDF–935K
8.
Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif
Alexander J. Frey, Salam Ibrahim, Scott Gleim, John Hwa, Emer M. Smyth
J Lipid Res. 2013 Jun; 54(6): 1678–1690. doi: 10.1194/jlr.M036673
PMCID:
PMC3646468
AbstractArticlePDF–1.3M
9.
Heterodimerization with the Prostacyclin Receptor Triggers Thromboxane Receptor Relocation to Lipid Rafts
Salam Ibrahim, Ann McCartney, Nune Markosyan, Emer M Smyth
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1): 60–66. Published online 2012 Nov 15. doi: 10.1161/ATVBAHA.112.300536
PMCID:
PMC3533363
AbstractArticlePDF–704K
10.
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins, Stephan Ripke, Rinse K Weersma, Richard H Duerr, Dermot P McGovern, Ken Y Hui, James C Lee, L Philip Schumm, Yashoda Sharma, Carl A Anderson, Jonah Essers, Mitja Mitrovic, Kaida Ning, Isabelle Cleynen, Emilie Theatre, Sarah L Spain, Soumya Raychaudhuri, Philippe Goyette, Zhi Wei, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Leila Amininejad, Ashwin N Ananthakrishnan, Vibeke Andersen, Jane M Andrews, Leonard Baidoo, Tobias Balschun, Peter A Bampton, Alain Bitton, Gabrielle Boucher, Stephan Brand, Carsten Büning, Ariella Cohain, Sven Cichon, Mauro D’Amato, Dirk De Jong, Kathy L Devaney, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Lynnette R Ferguson, Denis Franchimont, Karin Fransen, Richard Gearry, Michel Georges, Christian Gieger, Jürgen Glas, Talin Haritunians, Ailsa Hart, Chris Hawkey, Matija Hedl, Xinli Hu, Tom H Karlsen, Limas Kupcinskas, Subra Kugathasan, Anna Latiano, Debby Laukens, Ian C Lawrance, Charlie W Lees, Edouard Louis, Gillian Mahy, John Mansfield, Angharad R Morgan, Craig Mowat, William Newman, Orazio Palmieri, Cyriel Y Ponsioen, Uros Potocnik, Natalie J Prescott, Miguel Regueiro, Jerome I Rotter, Richard K Russell, Jeremy D Sanderson, Miquel Sans, Jack Satsangi, Stefan Schreiber, Lisa A Simms, Jurgita Sventoraityte, Stephan R Targan, Kent D Taylor, Mark Tremelling, Hein W Verspaget, Martine De Vos, Cisca Wijmenga, David C Wilson, Juliane Winkelmann, Ramnik J Xavier, Sebastian Zeissig, Bin Zhang, Clarence K Zhang, Hongyu Zhao, The International IBD Genetics Consortium, Mark S Silverberg, Vito Annese, Hakon Hakonarson, Steven R Brant, Graham Radford-Smith, Christopher G Mathew, John D Rioux, Eric E Schadt, Mark J Daly, Andre Franke, Miles Parkes, Severine Vermeire, Jeffrey C Barrett, Judy H Cho
Nature. Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: Nature. 2012 Nov 1; 491(7422): 119–124. doi: 10.1038/nature11582
PMCID:
PMC3491803
AbstractArticlePDF–706K
11.
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel
Meera Sridharan, Elizabeth A. Bowles, Jennifer P. Richards, Medina Krantic, Katie L. Davis, Kristine A. Dietrich, Alan H. Stephenson, Mary L. Ellsworth, Randy S. Sprague
Am J Physiol Heart Circ Physiol. 2012 Feb 1; 302(3): H553–H559. Published online 2011 Dec 9. doi: 10.1152/ajpheart.00998.2011
PMCID:
PMC3353798
AbstractArticle
12.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
13.
Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis
Elizebeth C. Turner, Eamon P. Mulvaney, Helen M. Reid, B. Therese Kinsella
Mol Biol Cell. 2011 Aug 1; 22(15): 2664–2679. doi: 10.1091/mbc.E11-04-0374
PMCID:
PMC3145543
AbstractArticlePDF–4.1M
14.
Maternal Levels of Prostacyclin, Thromboxane, ICAM, and VCAM in Normal and Preeclamptic Pregnancies
David F. Lewis, Bernard J. Canzoneri, Yang Gu, Shuang Zhao, Yuping Wang
Am J Reprod Immunol. Author manuscript; available in PMC 2011 Dec 1.
Published in final edited form as: Am J Reprod Immunol. 2010 Dec; 64(6): 376–383. doi: 10.1111/j.1600-0897.2010.00861.x
PMCID:
PMC3062267
AbstractArticlePDF–354K
15.
A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor
Feng Ni, Shui-Ping So, Vanessa Cervantes, Ke-He Ruan
FEBS J. Author manuscript; available in PMC 2011 Mar 1.
Published in final edited form as: FEBS J. 2008 Jan; 275(1): 128–137. Published online 2007 Nov 27. doi: 10.1111/j.1742-4658.2007.06183.x
PMCID:
PMC3046732
AbstractArticlePDF–823K
16.
Comprehensive Biochemical Analysis of Rare Prostacyclin Receptor Variants: STUDY OF ASSOCIATION OF SIGNALING WITH CORONARY ARTERY OBSTRUCTION
Jeremiah Stitham, Eric Arehart, Larkin Elderon, Scott R. Gleim, Karen Douville, Zsolt Kasza, Kristina Fetalvero, Todd MacKenzie, John Robb, Kathleen A. Martin, John Hwa
J Biol Chem. 2011 Mar 4; 286(9): 7060–7069. Published online 2010 Dec 28. doi: 10.1074/jbc.M110.124933
PMCID:
PMC3044963
AbstractArticlePDF–1.9M
17.
Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension
Emilia Falcetti, Susan M. Hall, Peter G. Phillips, Jigisha Patel, Nicholas W. Morrell, Sheila G. Haworth, Lucie H. Clapp
Am J Respir Crit Care Med. 2010 Nov 1; 182(9): 1161–1170. Published online 2010 Jul 9. doi: 10.1164/rccm.201001-0011OC
PMCID:
PMC3001258
AbstractArticlePDF–1.7M
18.
Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study
Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators
Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452
PMCID:
PMC2945168
AbstractArticlePDF–153K
19.
Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease
Salam Ibrahim, Mazell Tetruashvily, Alex J Frey, Stephen J Wilson, Jeremiah Stitham, John Hwa, Emer M Smyth
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2011 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9): 1802–1809. Published online 2010 Jun 3. doi: 10.1161/ATVBAHA.110.208900
PMCID:
PMC2924460
AbstractArticlePDF–1.4M
20.
Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation, potential implications for COX-2 inhibition
Eric Arehart, Jeremiah Stitham, Folkert W. Asselbergs, Karen Douville, Todd MacKenzie, Kristina M. Fetalvero, Scott Gleim, Zsolt Kasza, Yamini Rao, Laurie Martel, Sharon Segel, John Robb, Aaron Kaplan, Michael Simons, Richard J. Powell, Jason H. Moore, Eric B. Rimm, Kathleen A. Martin, John Hwa
Circ Res. Author manuscript; available in PMC 2009 Dec 15.
Published in final edited form as: Circ Res. 2008 Apr 25; 102(8): 986–993. Published online 2008 Mar 6. doi: 10.1161/CIRCRESAHA.107.165936
PMCID:
PMC2793685
AbstractArticlePDF–1.6M

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