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Select item 112035451.

Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss

Angelique R. Wise, Sara Maloney, Adam Hering, Sarah Zabala, Grace E. Richmond, Monica K. VanKlompenberg, Murlidharan T. Nair, Jenifer R. Prosperi

Int J Mol Sci. 2024 Jun; 25(12): 6745. Published online 2024 Jun 19. doi: 10.3390/ijms25126745

PMCID:: PMC11203545

Abstract Article PDF–1.5M

Select item 111599972.

A nonsense mutation in exon 8 of the APC gene (Arg283Ter) causes clinically variable FAP in a Malaysian Chinese family

Zulqarnain Mohamed, Rahimah Ahmad, Ng Sau Yoke, Zubaidah Zakaria, Harun Ahmad, Tong Hung Yew

Cancer Sci. 2003 Aug; 94(8): 725–728. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01509.x

PMCID:: PMC11159997

Abstract Article PDF–124K

Select item 111589343.

APC promoter hypermethylation is an early event in endometrial tumorigenesis

Atanas Ignatov, Joachim Bischoff, Tanja Ignatov, Christa Schwarzenau, Thomas Krebs, Doerthe Kuester, Serban D. Costa, Albert Roessner, Andrzej Semczuk, Regine Schneider‐Stock

Cancer Sci. 2010 Feb; 101(2): 321–327. Published online 2009 Oct 12. doi: 10.1111/j.1349-7006.2009.01397.x

PMCID:: PMC11158934

Abstract Article PDF–317K

Select item 111481844.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108492155.

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53

Mohamed Bourmoum, Nikolina Radulovich, Amit Sharma, Johnny M. Tkach, Ming-Sound Tsao, Laurence Pelletier

PLoS One. 2024; 19(2): e0295030. Published online 2024 Feb 7. doi: 10.1371/journal.pone.0295030

PMCID:: PMC10849215

Abstract Article PDF–2.1M

Select item 108178416.

APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation

Dan Zhang, Qi-Qi Ni, Shu-Yang Wang, Wen-Feng He, Ze-Xuan Hong, Hui-Ye Liu, Xiao-Hong Chen, Li-Jie Chen, Fang-Yi Han, Ling-Jie Zhang, Xiao-ming Li, Yan-qing Ding, Hong-li Jiao, Ya-ping Ye

Cell Mol Life Sci. 2024 Dec; 81(1): 57. Published online 2024 Jan 27. doi: 10.1007/s00018-023-05068-0

PMCID:: PMC10817841

Abstract Article PDF–6.2M

Select item 105658767.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 103592068.

APC ameliorates idiopathic membranous nephropathy by affecting podocyte apoptosis through the ERK1/2/YB-1/PLA2R1 axis

Ben Ke, Wen Shen, Yunfei Liao, Jing Hu, Weiping Tu, Xiangdong Fang

Mol Cell Biochem. 2023; 478(9): 1999–2011. Published online 2023 Jan 2. doi: 10.1007/s11010-022-04650-7

PMCID:: PMC10359206

Abstract Article PDF–7.9M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1015486710.

Let‐7b‐5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1

Yuyang Dai, Jinsong Liu, Xuyan Li, Jianzhong Deng, Cheng Zeng, Wenbin Lu, Yongzhong Hou, Ying Sheng, Honglin Wu, Qian Liu

Cancer Sci. 2023 May; 114(5): 1882–1897. Published online 2022 Dec 9. doi: 10.1111/cas.15678

Correction in:: Cancer Sci. 2023 Aug; 114(8): 3466–3469.

PMCID:: PMC10154867

Abstract Article PDF–30M

Select item 1002542511.

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage

Cell Genom. 2023 Mar 8; 3(3): 100250. Published online 2023 Jan 24. doi: 10.1016/j.xgen.2022.100250

PMCID:: PMC10025425

Abstract Article PDF–22M

Select item 1000233512.

Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth

Chomchanok Panyarat, Siriruk Nakornchai, Kanoknart Chintakanon, Niramol Leelaadisorn, Worrachet Intachai, Bjorn Olsen, Sissades Tongsima, Ploy Adisornkanj, Chumpol Ngamphiw, Timothy C. Cox, Piranit Kantaputra

Int J Mol Sci. 2023 Mar; 24(5): 4255. Published online 2023 Feb 21. doi: 10.3390/ijms24054255

PMCID:: PMC10002335

Abstract Article PDF–3.3M

Select item 999012013.

Interactomes of Glycogen Synthase Kinase-3 Isoforms

Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett

J Proteome Res. 2023 Mar 3; 22(3): 977–989. Published online 2023 Feb 13. doi: 10.1021/acs.jproteome.2c00825

PMCID:: PMC9990120

Abstract Article PDF–3.7M

Select item 976969814.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 958789215.

The Mutation Spectrum and Two Novel Point Mutations in the APC Gene in Vietnamese Patients with Familial Adenomatous Polyposis

Bac Hoang Nguyen, Suong Thi Bang Nguyen, Huy Huu Nguyen, Tin Trung Nguyen, Khoi Minh Le

Asian Pac J Cancer Prev. 2022 May; 23(5): 1517–1522. doi: 10.31557/APJCP.2022.23.5.1517

PMCID:: PMC9587892

Abstract Article PDF–1.3M

Select item 956995516.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 955406617.

Constitutional chromothripsis of the APC locus as a cause of genetic predisposition to colon cancer

Florentine Scharf, Rafaela Magalhaes Leal Silva, Monika Morak, Alex Hastie, Julia M A Pickl, Kai Sendelbach, Christian Gebhard, Melanie Locher, Andreas Laner, Verena Steinke-Lange, Udo Koehler, Elke Holinski-Feder, Dieter A Wolf

J Med Genet. 2022 Oct; 59(10): 976–983. Published online 2021 Dec 14. doi: 10.1136/jmedgenet-2021-108147

PMCID:: PMC9554066

Abstract Article PDF–1.7M

Select item 954942118.

CDH1、FANCB和APC基因多态性与中国人群肺癌易感性的关系

苏联椿, 黄华, 高敏, 李永文, 施睿峰, 陈琛, 李宣广, 朱光胜, 刘红雨, 陈军

Zhongguo Fei Ai Za Zhi. 2022 Sep 20; 25(9): 658–664. Chinese. doi: 10.3779/j.issn.1009-3419.2022.102.21

PMCID:: PMC9549421

Abstract Article PDF–1.9M

Select item 951327119.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 943393820.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

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