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Items: 1 to 20 of 44

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
Qiong Zhu, Yesheng Fu, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu, Lingqiang Zhang
Signal Transduct Target Ther. 2023; 8: 142. Published online 2023 Apr 7. doi: 10.1038/s41392-023-01354-2
PMCID:
PMC10079838
AbstractArticlePDF–5.3M
3.
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis
Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu
J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054
PMCID:
PMC10040876
AbstractArticlePDF–3.0M
4.
The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle
Dina Aweida, Shenhav Cohen
EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175
PMCID:
PMC9724657
AbstractArticlePDF–3.0M
5.
Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment
Annika Stutz, Gopala Nishanth, Ana C. Zenclussen, Anne Schumacher
BMC Res Notes. 2022; 15: 341. Published online 2022 Nov 5. doi: 10.1186/s13104-022-06230-w
PMCID:
PMC9636684
AbstractArticlePDF–1.0M
6.
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis
Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu
iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363
PMCID:
PMC9626688
AbstractArticlePDF–6.0M
7.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
8.
ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1
Xiaodan Zhong, Tao Wang, Wenjun Zhang, Mengwen Wang, Yang Xie, Lei Dai, Xingwei He, Thati Madhusudhan, Hesong Zeng, Hongjie Wang
J Biol Chem. 2022 Jun; 298(6): 101989. Published online 2022 Apr 28. doi: 10.1016/j.jbc.2022.101989
PMCID:
PMC9163515
AbstractArticlePDF–3.2M
9.
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monné Rodríguez, Julia Günter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Int J Mol Sci. 2022 Feb; 23(3): 1536. Published online 2022 Jan 28. doi: 10.3390/ijms23031536
PMCID:
PMC8836018
AbstractArticlePDF–3.1M
10.
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation
Josephin Koschel, Gopala Nishanth, Sissy Just, Kunjan Harit, Andrea Kröger, Martina Deckert, Michael Naumann, Dirk Schlüter
Cell Death Differ. 2021 Jul; 28(7): 2257–2275. Published online 2021 Mar 12. doi: 10.1038/s41418-021-00752-9
Correction in:
Cell Death Differ. 2022 Apr; 29(4): 891.
PMCID:
PMC8257688
AbstractArticlePDF–6.7M
11.
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13
Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlüter
Cell Mol Immunol. 2021 Jun; 18(6): 1512–1527. Published online 2020 Feb 5. doi: 10.1038/s41423-020-0362-6
PMCID:
PMC8167118
AbstractArticlePDF–4.4M
12.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
13.
Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization
Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S. Li, Stephanie S. Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun
Cell Res. 2019 Jun; 29(6): 474–485. Published online 2019 May 13. doi: 10.1038/s41422-019-0174-3
PMCID:
PMC6796864
AbstractArticlePDF–4.8M
14.
The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming
Xiaofei Zhou, Jiayi Yu, Xuhong Cheng, Baoyu Zhao, Ganiraju C Manyam, Li Zhang, Kimberly Schluns, Pingwei Li, Jing Wang, Shao-Cong Sun
Nat Immunol. Author manuscript; available in PMC 2019 Dec 10.
Published in final edited form as: Nat Immunol. 2019 Jul; 20(7): 879–889. Published online 2019 Jun 10. doi: 10.1038/s41590-019-0405-2
PMCID:
PMC6588407
AbstractArticlePDF–3.3M
15.
OTUB1 inhibits CNS autoimmunity by preventing IFN‐γ‐induced hyperactivation of astrocytes
Xu Wang, Floriana Mulas, Wenjing Yi, Anna Brunn, Gopala Nishanth, Sissy Just, Ari Waisman, Wolfgang Brück, Martina Deckert, Dirk Schlüter
EMBO J. 2019 May 15; 38(10): e100947. Published online 2019 Apr 3. doi: 10.15252/embj.2018100947
PMCID:
PMC6517825
AbstractArticlePDF–3.4M
16.
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination
Nagesh Pasupala, Marie E. Morrow, Lauren T. Que, Barbara A. Malynn, Averil Ma, Cynthia Wolberger
J Biol Chem. 2018 Nov 23; 293(47): 18285–18295. Published online 2018 Oct 2. doi: 10.1074/jbc.RA118.004677
PMCID:
PMC6254341
AbstractArticlePDF–1.0M
17.
Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells
Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch
Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262
PMCID:
PMC6244183
AbstractArticlePDF–753K
18.
RNA binding proteins co-localize with small tau inclusions in tauopathy
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
Acta Neuropathol Commun. 2018; 6: 71. Published online 2018 Aug 1. doi: 10.1186/s40478-018-0574-5
PMCID:
PMC6069705
AbstractArticlePDF–5.5M
19.
An N-terminal motif unique to primate tau enables differential protein–protein interactions
Kristie Stefanoska, Alexander Volkerling, Josefine Bertz, Anne Poljak, Yazi D. Ke, Lars M. Ittner, Arne Ittner
J Biol Chem. 2018 Mar 9; 293(10): 3710–3719. Published online 2018 Jan 30. doi: 10.1074/jbc.RA118.001784
PMCID:
PMC5846163
AbstractArticlePDF–1.2M
20.
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo
Peng Wang, Gerard Joberty, Arjan Buist, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu, Bruno Vasconcelos, Nathalie Pierrot, Maria Faelth-Savitski, Pascal Kienlen-Campard, Jean-Noël Octave, Marcus Bantscheff, Gerard Drewes, Diederik Moechars, Ilse Dewachter
Acta Neuropathol. 2017; 133(5): 731–749. Published online 2017 Jan 12. doi: 10.1007/s00401-016-1663-9
PMCID:
PMC5390007
AbstractArticlePDF–3.0M

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