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Select item 82213491.

Identification of RHOBTB2 aberration as an independent prognostic indicator in acute myeloid leukemia

Peng Liu, Qinghai Ma, Hanxiang Chen, Li Zhang, Xiaoning Zhang

Aging (Albany NY) 2021 Jun 15; 13(11): 15269–15284. Published online 2021 Jun 1. doi: 10.18632/aging.203087

PMCID:: PMC8221349

Abstract Article PDF–2.0M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80323763.

RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood

Sara Zagaglia, Dora Steel, S. Krithika, Laura Hernandez-Hernandez, Helena Martins Custodio, Kathleen M. Gorman, Aikaterini Vezyroglou, Rikke S. Møller, Mary D. King, Trine Bjørg Hammer, Robert Spaull, Walid Fazeli, Tobias Bartolomaeus, Diane Doummar, Boris Keren, Cyril Mignot, Nathalie Bednarek, J. Helen Cross, Andrew A. Mallick, Alba Sanchis-Juan, Anna Basu, F. Lucy Raymond, Bryan J. Lynch, Anirban Majumdar, Hannah Stamberger, Sarah Weckhuysen, Sanjay M. Sisodiya, Manju A. Kurian

Neurology. 2021 Mar 16; 96(11): e1539–e1550. doi: 10.1212/WNL.0000000000011543

PMCID:: PMC8032376

Abstract Article PDF–275K

Select item 74273274.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 58269265.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 57773816.

Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila

Jonas Straub, Enrico D.H. Konrad, Johanna Grüner, Annick Toutain, Levinus A. Bok, Megan T. Cho, Heather P. Crawford, Holly Dubbs, Ganka Douglas, Rebekah Jobling, Diana Johnson, Bryan Krock, Mohamad A. Mikati, Addie Nesbitt, Joost Nicolai, Meredith Phillips, Annapurna Poduri, Xilma R. Ortiz-Gonzalez, Zöe Powis, Avni Santani, Lacey Smith, Alexander P.A. Stegmann, Constance Stumpel, Maaike Vreeburg, Deciphering Developmental Disorders Study, Anna Fliedner, Anne Gregor, Heinrich Sticht, Christiane Zweier

Am J Hum Genet. 2018 Jan 4; 102(1): 44–57. Published online 2017 Dec 21. doi: 10.1016/j.ajhg.2017.11.008

PMCID:: PMC5777381

Abstract Article PDF–1.7M

Select item 56785817.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 54424189.

DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer

Y M Choi, K B Kim, J H Lee, Y K Chun, I S An, S An, S Bae

Oncogene. 2017 May 18; 36(20): 2802–2812. Published online 2016 Dec 12. doi: 10.1038/onc.2016.441

PMCID:: PMC5442418

Abstract Article PDF–3.2M

Select item 493167710.

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Wei Ji, Francisco Rivero

Cells. 2016 Jun; 5(2): 28. Published online 2016 Jun 14. doi: 10.3390/cells5020028

PMCID:: PMC4931677

Abstract Article PDF–1.7M

Select item 462780911.

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

Thomas L. Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, Candy Rivas, Sylvia Alarcon, Harvey Schwartz, Kofi Khamit-Kush, Bradley T. Scroggins, Kristin Beebe, Jane B. Trepel, Len Neckers

PLoS One. 2015; 10(10): e0141786. Published online 2015 Oct 30. doi: 10.1371/journal.pone.0141786

PMCID:: PMC4627809

Abstract Article PDF–2.6M

Select item 394647912.

Hsp90-Dependent Assembly of the DBC2/RhoBTB2-Cullin3 E3-Ligase Complex

Jacob R. Manjarrez, Liang Sun, Thomas Prince, Robert L. Matts

PLoS One. 2014; 9(3): e90054. Published online 2014 Mar 7. doi: 10.1371/journal.pone.0090054

PMCID:: PMC3946479

Abstract Article PDF–3.5M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 300858614.

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Eric J. Bennett, John Rush, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2011 Dec 10.

Published in final edited form as: Cell. 2010 Dec 10; 143(6): 951–965. doi: 10.1016/j.cell.2010.11.017

PMCID:: PMC3008586

Abstract Article PDF–3.0M

Select item 292822415.

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity

HD Hosgood, III, L Zhang, M Shen, SI Berndt, R Vermeulen, G Li, S Yin, M Yeager, J Yuenger, N Rothman, S Chanock, M Smith, Q Lan

Occup Environ Med. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Occup Environ Med. 2009 Dec; 66(12): 848–853. Published online 2009 Sep 22. doi: 10.1136/oem.2008.044024

PMCID:: PMC2928224

Abstract Article PDF–321K

Select item 274972916.

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes –Evidence for an autoregulatory mechanism

Jessica Berthold, Kristína Schenková, Sonia Ramos, Yoshie Miura, Manabu Furukawa, Pontus Aspenström, Francisco Rivero

Exp Cell Res. Author manuscript; available in PMC 2009 Nov 15.

Published in final edited form as: Exp Cell Res. 2008 Nov 15; 314(19): 3453–3465. Published online 2008 Sep 20. doi: 10.1016/j.yexcr.2008.09.005

PMCID:: PMC2749729

Abstract Article PDF–3.2M

Select item 226852617.

RHOBTB2 (DBC2) IS A MITOTIC E2F1 TARGET GENE WITH A NOVEL ROLE IN APOPTOSIS

Scott N. Freeman, Yihong Ma, W. Douglas Cress

J Biol Chem. Author manuscript; available in PMC 2008 Mar 17.

Published in final edited form as: J Biol Chem. 2008 Jan 25; 283(4): 2353–2362. Published online 2007 Nov 26. doi: 10.1074/jbc.M705986200

PMCID:: PMC2268526

Abstract Article PDF–2.2M

Select item 198672718.

DBC2 Resistance is Achieved by Enhancing 26S Proteasome-mediated Protein Degradation

Denise Collado, Takashi Yoshihara, Masaaki Hamaguchi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2008 Aug 31.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Aug 31; 360(3): 600–603. Published online 2007 Jul 2. doi: 10.1016/j.bbrc.2007.06.127

PMCID:: PMC1986727

Abstract Article PDF–305K

Select item 193461819.

Cyclin D1 Down-regulation is Essential for DBC2's Tumor Suppressor Function

Takashi Yoshihara, Denise Collado, Masaaki Hamaguchi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2008 Jul 13.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Jul 13; 358(4): 1076–1079. Published online 2007 May 15. doi: 10.1016/j.bbrc.2007.05.037

PMCID:: PMC1934618

Abstract Article PDF–130K

Select item 171326520.

DBC2 is Essential for Transporting Vesicular Stomatitis Virus Glycoprotein

Faith K. Chang, Noriko Sato, Noriko Kobayashi-Simorowski, Takashi Yoshihara, Jennifer L. Meth, Masaaki Hamaguchi

J Mol Biol. Author manuscript; available in PMC 2007 Dec 1.

Published in final edited form as: J Mol Biol. 2006 Dec 1; 364(3): 302–308. Published online 2006 Sep 15. doi: 10.1016/j.jmb.2006.09.026

PMCID:: PMC1713265

Abstract Article PDF–848K

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