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Select item 109333321.

mRNA nuclear retention reduces AMPAR expression and promotes autistic behavior in UBE3A-overexpressing mice

Yuan Tian, Feiyuan Yu, Eunice Yun, Jen-Wei Lin, Heng-Ye Man

EMBO Rep. 2024 Mar; 25(3): 1282–1309. Published online 2024 Feb 5. doi: 10.1038/s44319-024-00073-1

PMCID:: PMC10933332

Abstract Article PDF–6.9M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106162313.

Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses

Wenyue Su, Yan Liu, Aileen Lam, Xiaoning Hao, Michel Baudry, Xiaoning Bi

Sci Rep. 2023; 13: 18647. Published online 2023 Oct 30. doi: 10.1038/s41598-023-45769-x

PMCID:: PMC10616231

Abstract Article PDF–4.0M

Select item 105304564.

Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112706. Published online 2023 Jun 28. doi: 10.1016/j.celrep.2023.112706

PMCID:: PMC10530456

Abstract Article PDF–4.5M

Select item 104765615.

UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells

Yanyan Luo, Yun Yang, Cong Yang, Chuanyin Li, Ronggui Hu, Wujun Geng, Xianhui Kang, Hai Lin

FEBS Open Bio. 2023 Sep; 13(9): 1756–1771. Published online 2023 Jul 28. doi: 10.1002/2211-5463.13675

PMCID:: PMC10476561

Abstract Article PDF–5.1M

Select item 103623816.

A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice

Jinhui Li, Zhixin Shen, Yajing Liu, Zixiang Yan, Yuanhua Liu, Xiang Lin, Junjie Tang, Ruimin Lv, Guannan Geng, Zhi-Qi Xiong, Changyang Zhou, Hui Yang

Mol Ther. 2023 Jul 5; 31(7): 2286–2295. Published online 2023 Feb 18. doi: 10.1016/j.ymthe.2023.02.015

PMCID:: PMC10362381

Abstract Article PDF–3.3M

Select item 103593307.

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy

Nat Commun. 2023; 14: 4385. Published online 2023 Jul 20. doi: 10.1038/s41467-023-40054-x

PMCID:: PMC10359330

Abstract Article PDF–3.3M

Select item 102765398.

Excessive protein accumulation and impaired autophagy in the hippocampus of Angelman syndrome modeled in mice

Francesca Aria, Kiran Pandey, Cristina M. Alberini

Biol Psychiatry. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Biol Psychiatry. 2023 Jul 1; 94(1): 68–83. Published online 2022 Dec 5. doi: 10.1016/j.biopsych.2022.11.016

PMCID:: PMC10276539

Abstract Article PDF–2.7M

Select item 101106039.

Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model

Kiyoshi Egawa, Miho Watanabe, Hideaki Shiraishi, Daisuke Sato, Yukitoshi Takahashi, Saori Nishio, Atsuo Fukuda

Sci Rep. 2023; 13: 5685. Published online 2023 Apr 17. doi: 10.1038/s41598-023-32376-z

PMCID:: PMC10110603

Abstract Article PDF–2.5M

Select item 1007759510.

Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1

Kangli Peng, Shirong Wang, Ruochuan Liu, Li Zhou, Geon H. Jeong, In Ho Jeong, Xianpeng Liu, Hiroaki Kiyokawa, Bingzhong Xue, Bo Zhao, Hang Shi, Jun Yin

Biochemistry. 2023 Apr 4; 62(7): 1274–1286. Published online 2023 Mar 15. doi: 10.1021/acs.biochem.2c00624

PMCID:: PMC10077595

Abstract Article PDF–7.0M

Select item 1007334411.

UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways

Xiaoning Hao, Jiandong Sun, Li Zhong, Michel Baudry, Xiaoning Bi

Exp Neurol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Exp Neurol. 2023 May; 363: 114358. Published online 2023 Feb 26. doi: 10.1016/j.expneurol.2023.114358

PMCID:: PMC10073344

Abstract Article PDF–1.7M

Select item 997796312.

Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome

Luis O. Romero, Rebeca Caires, A. Kaitlyn Victor, Juanma Ramirez, Francisco J. Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T. Reiter, Valeria Vásquez, Julio F. Cordero-Morales

Nat Commun. 2023; 14: 1167. Published online 2023 Mar 1. doi: 10.1038/s41467-023-36818-0

PMCID:: PMC9977963

Abstract Article PDF–33M

Select item 997751013.

UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation

Diana C. Rotaru, Ilse Wallaard, Maud de Vries, Julia van der Bie, Ype Elgersma

JCI Insight. 2023 Feb 22; 8(4): e166073. Published online 2023 Feb 22. doi: 10.1172/jci.insight.166073

PMCID:: PMC9977510

Abstract Article PDF–4.3M

Select item 990475914.

Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome

Dongwon Lee, Wu Chen, Heet Naresh Kaku, Xinming Zhuo, Eugene S Chao, Armand Soriano, Allen Kuncheria, Stephanie Flores, Joo Hyun Kim, Armando Rivera, Frank Rigo, Paymaan Jafar-nejad, Arthur L Beaudet, Matthew S Caudill, Mingshan Xue

eLife. 2023; 12: e81892. Published online 2023 Jan 3. doi: 10.7554/eLife.81892

Correction in:: eLife. 2024; 13: e104349.

PMCID:: PMC9904759

Abstract Article PDF–9.2M

Select item 982046015.

The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome

Eva M. G. Viho, A. Mattijs Punt, Ben Distel, René Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer

Int J Mol Sci. 2023 Jan; 24(1): 303. Published online 2022 Dec 24. doi: 10.3390/ijms24010303

PMCID:: PMC9820460

Abstract Article PDF–3.4M

Select item 967556416.

Molecular and behavioral consequences of Ube3a gene overdosage in mice

A. Mattijs Punt, Matthew C. Judson, Michael S. Sidorov, Brittany N. Williams, Naomi S. Johnson, Sabine Belder, Dion den Hertog, Courtney R. Davis, Maximillian S. Feygin, Patrick F. Lang, Mehrnoush Aghadavoud Jolfaei, Patrick J. Curran, Wilfred F.J. van IJcken, Ype Elgersma, Benjamin D. Philpot

JCI Insight. 2022 Sep 22; 7(18): e158953. Published online 2022 Sep 22. doi: 10.1172/jci.insight.158953