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Select item 87707031.

Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients

Julia C. F. Quintanilha, Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, Flora Mulkey, Jai N. Patel, Daniel L. Hertz, Elizabeth Claire Dees, Howard L. McLeod, Monica Bertagnolli, Hope Rugo, Hedy L. Kindler, William Kevin Kelly, Mark J. Ratain, Deanna L. Kroetz, Kouros Owzar, Bryan P. Schneider, Danyu Lin, Federico Innocenti

Br J Cancer. 2022 Feb 1; 126(2): 265–274. Published online 2021 Oct 6. doi: 10.1038/s41416-021-01557-w

Correction in:: Br J Cancer. 2022 Jan 1; 126(1): 162.

PMCID:: PMC8770703

Abstract Article PDF–581K

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78662473.

K_V1.5–K_Vβ1.3 Recycling Is PKC-Dependent

Alvaro Macias, Alicia de la Cruz, Diego A. Peraza, Angela de Benito-Bueno, Teresa Gonzalez, Carmen Valenzuela

Int J Mol Sci. 2021 Feb; 22(3): 1336. Published online 2021 Jan 29. doi: 10.3390/ijms22031336

PMCID:: PMC7866247

Abstract Article PDF–2.1M

Select item 77035944.

The potassium channel subunit K_vβ1 serves as a major control point for synaptic facilitation

In Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, Michael B. Hoppa

Proc Natl Acad Sci U S A. 2020 Nov 24; 117(47): 29937–29947. Published online 2020 Nov 9. doi: 10.1073/pnas.2000790117

PMCID:: PMC7703594

Abstract Article PDF–1.7M

Select item 55316115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 52609396.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 50365277.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 46479418.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 46172119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 429411410.

PKC inhibition results in a K_v1.5 + K_vβ1.3 pharmacology closer to K_v1.5 channels

A Macías, A de la Cruz, A Prieto, D A Peraza, M M Tamkun, T González, C Valenzuela

Br J Pharmacol. 2014 Nov; 171(21): 4914–4926. Published online 2014 Sep 5. doi: 10.1111/bph.12822

PMCID:: PMC4294114

Abstract Article PDF–1.6M

Select item 337556311.

Protein Kinase C (PKC) Activity Regulates Functional Effects of K_vβ1.3 Subunit on K_V1.5 Channels: IDENTIFICATION OF A CARDIAC K_v1.5 CHANNELOSOME

Miren David, Álvaro Macías, Cristina Moreno, Ángela Prieto, Ramón Martínez-Mármol, Rubén Vicente, Teresa González, Antonio Felipe, Michael M. Tamkun, Carmen Valenzuela

J Biol Chem. 2012 Jun 15; 287(25): 21416–21428. Published online 2012 Apr 30. doi: 10.1074/jbc.M111.328278

PMCID:: PMC3375563

Abstract Article PDF–4.1M

Select item 319082612.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 289646414.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 282448815.

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

Avinash Persaud, Philipp Alberts, Eva M Amsen, Xuejian Xiong, James Wasmuth, Zachary Saadon, Chris Fladd, John Parkinson, Daniela Rotin

Mol Syst Biol. 2009; 5: 333. Published online 2009 Dec 1. doi: 10.1038/msb.2009.85

PMCID:: PMC2824488

Abstract Article PDF–3.1M

Select item 268304716.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 259987417.

Structural determinants of Kvβ1.3-induced channel inactivation: a hairpin modulated by PIP₂

Niels Decher, Teresa Gonzalez, Anne Kathrin Streit, Frank B Sachse, Vijay Renigunta, Malle Soom, Stefan H Heinemann, Jürgen Daut, Michael C Sanguinetti

EMBO J. 2008 Dec 3; 27(23): 3164–3174. Published online 2008 Nov 6. doi: 10.1038/emboj.2008.231

PMCID:: PMC2599874

Abstract Article PDF–2.0M

Select item 199560418.

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

Kathryn L Lunetta, Ralph B D'Agostino, Sr, David Karasik, Emelia J Benjamin, Chao-Yu Guo, Raju Govindaraju, Douglas P Kiel, Margaret Kelly-Hayes, Joseph M Massaro, Michael J Pencina, Sudha Seshadri, Joanne M Murabito

BMC Med Genet. 2007; 8(Suppl 1): S13. Published online 2007 Sep 19. doi: 10.1186/1471-2350-8-S1-S13

PMCID:: PMC1995604

Abstract Article PDF–308K

Select item 194810019.

NADPH Binding to β-Subunit Regulates Inactivation of Voltage-Gated K⁺ Channels

Srinivas M. Tipparaju, Si-Qi Liu, Oleg Barski, Aruni Bhatnagar

Biochem Biophys Res Commun. Author manuscript; available in PMC 2008 Jul 27.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Jul 27; 359(2): 269–276. Published online 2007 May 24. doi: 10.1016/j.bbrc.2007.05.102

PMCID:: PMC1948100

Abstract Article PDF–590K

Select item 191354520.

Functional specialization of β-arrestin interactions revealed by proteomic analysis

Kunhong Xiao, Daniel B. McClatchy, Arun K. Shukla, Yang Zhao, Minyong Chen, Sudha K. Shenoy, John R. Yates, III, Robert J. Lefkowitz

Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29): 12011–12016. Published online 2007 Jul 9. doi: 10.1073/pnas.0704849104

PMCID:: PMC1913545

Abstract Article PDF–712K

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