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Select item 106298221.

Mutant SF3B1 promotes malignancy in PDAC

Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank

eLife. 2023; 12: e80683. Published online 2023 Oct 12. doi: 10.7554/eLife.80683

PMCID:: PMC10629822

Abstract Article PDF–8.5M

Select item 94120072.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Blood. 2022 Aug 25; 140(8): 875–888. doi: 10.1182/blood.2021015325

PMCID:: PMC9412007

Abstract Article

Select item 91610093.

TRF2-mediated telomere protection is dispensable in pluripotent stem cells

Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi

Nature. Author manuscript; available in PMC 2022 Jun 2.

Published in final edited form as: Nature. 2021 Jan; 589(7840): 110–115. Published online 2020 Nov 25. doi: 10.1038/s41586-020-2959-4

PMCID:: PMC9161009

Abstract Article PDF–5.8M

Select item 87948504.

Disruption of MeCP2–TCF20 complex underlies distinct neurodevelopmental disorders

Jian Zhou, Hamdan Hamdan, Hari Krishna Yalamanchili, Kaifang Pang, Amy E. Pohodich, Joanna Lopez, Yingyao Shao, Juan A. Oses-Prieto, Lifang Li, Wonho Kim, Mark A. Durham, Sameer S. Bajikar, Donna J. Palmer, Philip Ng, Michelle L. Thompson, E. Martina Bebin, Amelie J. Müller, Alma Kuechler, Antje Kampmeier, Tobias B. Haack, Alma L. Burlingame, Zhandong Liu, Matthew N. Rasband, Huda Y. Zoghbi

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2119078119. Published online 2022 Jan 24. doi: 10.1073/pnas.2119078119

PMCID:: PMC8794850

Abstract Article PDF–2.4M

Select item 85595775.

Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response

Aaron Y. Chang, Yu Jerry Zhou, Sharanya Iyengar, Piotr W. Pobiarzyn, Pavel Tishchenko, Kesha M. Shah, Heather Wheeler, Yue-Ming Wang, Paula M. Loria, Frank Loganzo, Seng-Ryong Woo

J Biol Chem. 2021 Nov; 297(5): 101277. Published online 2021 Oct 5. doi: 10.1016/j.jbc.2021.101277

PMCID:: PMC8559577

Abstract Article PDF–2.4M

Select item 81885176.

Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab, Raul Rabadan

Cancer Discov. Author manuscript; available in PMC 2021 Jun 9.

Published in final edited form as: Cancer Discov. 2020 Jun; 10(6): 806–821. Published online 2020 Mar 18. doi: 10.1158/2159-8290.CD-19-1330

PMCID:: PMC8188517

Abstract Article PDF–4.1M

Select item 81770657.

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Daichi Inoue, Jacob T. Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti, Caroline Erickson, Katherine Knorr, Miki Fukumoto, Hiromi Yamazaki, Atsushi Tanaka, Chie Fukui, Sydney X. Lu, Benjamin H. Durham, Bo Liu, Eric Wang, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, Alex Penson, Guo-Liang Chew, Frank McCormick, Robert K. Bradley, Omar Abdel-Wahab

Nat Genet. Author manuscript; available in PMC 2021 Oct 12.

Published in final edited form as: Nat Genet. 2021 May; 53(5): 707–718. Published online 2021 Apr 12. doi: 10.1038/s41588-021-00828-9

PMCID:: PMC8177065

Abstract Article PDF–2.6M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77733709.

Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis

Bo Liu, Zhaoqi Liu, Sisi Chen, Michelle Ki, Caroline Erickson, Jorge S. Reis-Filho, Benjamin H. Durham, Qing Chang, Elisa de Stanchina, Yiwei Sun, Raul Rabadan, Omar Abdel-Wahab, Sarat Chandarlapaty

J Clin Invest. 2021 Jan 4; 131(1): e138315. Published online 2021 Jan 4. doi: 10.1172/JCI138315

PMCID:: PMC7773370

Abstract Article PDF–23M

Select item 776299810.

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing

Namjeong Choi, Yongchao Liu, Jagyeong Oh, Jiyeon Ha, Xuexiu Zheng, Haihong Shen

Cells. 2020 Dec; 9(12): 2647. Published online 2020 Dec 9. doi: 10.3390/cells9122647

PMCID:: PMC7762998

Abstract Article PDF–4.5M

Select item 768431911.

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Lin Jin, Yunjia Chen, David K. Crossman, Arunima Datta, Trung Vu, James A. Mobley, Malay Kumar Basu, Mariangela Scarduzio, Hengbin Wang, Chenbei Chang, Pran K. Datta

Nat Commun. 2020; 11: 5941. Published online 2020 Nov 23. doi: 10.1038/s41467-020-19698-6

PMCID:: PMC7684319

Abstract Article PDF–3.4M

Select item 699392512.

Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

Chao Wang, Bin Zhang, Anna C. Ratliff, Justine Arrington, Jingjuan Chen, Yan Xiong, Feng Yue, Yaohui Nie, Keping Hu, Wen Jin, W. Andy Tao, Christine A. Hrycyna, Xiaobo Sun, Shihuan Kuang

FASEB J. 2019 Aug; 33(8): 9672–9684. Published online 2019 Jun 4. doi: 10.1096/fj.201900582R

PMCID:: PMC6993925

Abstract Article

Select item 698565413.

Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing

Jing Li, Chenxin Wang, Guihai Feng, Linlin Zhang, Guilai Chen, Hao Sun, Jiaqiang Wang, Ying Zhang, Qi Zhou, Wei Li

Cell Prolif. 2020 Jan; 53(1): e12724. Published online 2019 Dec 3. doi: 10.1111/cpr.12724

PMCID:: PMC6985654

Abstract Article PDF–2.3M

Select item 637347214.

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eunjung Jang, Esther Obeng, Sydney X. Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Jing Zhang, Min Kyung Kim, Hana Cho, Young Rock Chung, Justin Taylor, Benjamin H. Durham, Young Joon Kim, Alessandro Pastore, Sebastien Monette, James Palacino, Michael Seiler, Silvia Buonamici, Peter G. Smith, Benjamin L. Ebert, Robert K. Bradley, Omar Abdel-Wahab

Cancer Cell. Author manuscript; available in PMC 2019 Aug 13.

Published in final edited form as: Cancer Cell. 2018 Aug 13; 34(2): 225–241.e8. doi: 10.1016/j.ccell.2018.07.003

PMCID:: PMC6373472

Abstract Article PDF–1.6M

Select item 637235615.

A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion

Shanye Yin, Rutendo G. Gambe, Jing Sun, Aina Zurita Martinez, Zachary J. Cartun, Fara Faye D. Regis, Youzhong Wan, Jean Fan, Angela N. Brooks, Sarah E.M. Herman, Elisa ten Hacken, Amaro Taylor-Weiner, Laura Z. Rassenti, Emanuela M. Ghia, Thomas J. Kipps, Esther A. Obeng, Carrie L. Cibulskis, Donna Neuberg, Dean R. Campagna, Mark D. Fleming, Benjamin L. Ebert, Adrian Wiestner, Ignaty Leshchiner, James A. DeCaprio, Gad Getz, Robin Reed, Ruben D. Carrasco, Catherine J. Wu, Lili Wang

Cancer Cell. Author manuscript; available in PMC 2019 Feb 12.

Published in final edited form as: Cancer Cell. 2019 Feb 11; 35(2): 283–296.e5. Published online 2019 Jan 31. doi: 10.1016/j.ccell.2018.12.013

PMCID:: PMC6372356

Abstract Article PDF–4.0M

Select item 626277716.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 586277117.

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury

Nat Genet. Author manuscript; available in PMC 2018 Aug 19.

Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7

PMCID:: PMC5862771

Abstract Article PDF–2.5M

Select item 564508218.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 556938719.

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities

Daichi Inoue, Omar Abdel-Wahab

Cancer Cell. Author manuscript; available in PMC 2017 Aug 24.

Published in final edited form as: Cancer Cell. 2016 Sep 12; 30(3): 371–373. doi: 10.1016/j.ccell.2016.08.013

PMCID:: PMC5569387

Abstract Article PDF–482K

Select item 538122620.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

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