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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103306082.

Quantitative Proteomic Profiling Identifies Global Protein Network Dynamics in Murine Embryonic Heart Development

Whitney Edwards, Todd M. Greco, Gregory E. Miner, Natalie K. Barker, Laura Herring, Sarah Cohen, Ileana M. Cristea, Frank L. Conlon

Dev Cell. Author manuscript; available in PMC 2024 Jun 19.

Published in final edited form as: Dev Cell. 2023 Jun 19; 58(12): 1087–1105.e4. Published online 2023 May 5. doi: 10.1016/j.devcel.2023.04.011

PMCID:: PMC10330608

Abstract Article PDF–3.6M

Select item 99239313.

Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen, Bin Xue

Mol Brain. 2023; 16: 24. Published online 2023 Feb 13. doi: 10.1186/s13041-023-01010-4

PMCID:: PMC9923931

Abstract Article PDF–8.3M

Select item 90145594.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 84366965.

Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice

Feng Zheng, Zhong Chen, Qiao-Li Tang, Xin-Ying Wang, Dan-Yang Chong, Tong-Yu Zhang, Ya-Yun Gu, Zhi-Bin Hu, Chao-Jun Li

J Mol Cell Biol. 2021 Jun; 13(6): 445–454. Published online 2021 Mar 24. doi: 10.1093/jmcb/mjab019

PMCID:: PMC8436696

Abstract Article PDF–1.4M

Select item 81049436.

Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction

Yong-Juan Sang, Qiang Wang, Feng Zheng, Yue Hua, Xin-Ying Wang, Jing-Zi Zhang, Kang Li, Hai-Quan Wang, Yue Zhao, Min-Sheng Zhu, Hai-Xiang Sun, Chao-Jun Li

J Mol Cell Biol. 2021 Feb; 13(2): 116–127. Published online 2020 Dec 19. doi: 10.1093/jmcb/mjaa066

PMCID:: PMC8104943

Abstract Article PDF–913K

Select item 76810127.

GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism

Lisha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li, Min-Sheng Zhu, Xuena Zhang

J Biol Chem. 2020 Nov 20; 295(47): 15988–16001. Published online 2020 Sep 10. doi: 10.1074/jbc.RA120.015020

PMCID:: PMC7681012

Abstract Article PDF–3.6M

Select item 70027408.

Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang, Xi-Tai Sun, Bin Xue, Chao-Jun Li

Nat Commun. 2020; 11: 719. Published online 2020 Feb 5. doi: 10.1038/s41467-020-14450-6

PMCID:: PMC7002740

Abstract Article PDF–2.9M

Select item 65544039.

The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis

Ruilou Zhu, Jiangnan Wang, Tianxiang Feng, Xuechun Hu, Chen Jiang, Xiuxing Wang, Kang Li, Yongjuan Sang, Yue Hua, Haixiang Sun, Bing Yao, Chaojun Li

Cell Death Dis. 2019 Jun; 10(6): 450. Published online 2019 Jun 6. doi: 10.1038/s41419-019-1688-9

PMCID:: PMC6554403

Abstract Article PDF–2.8M

Select item 529582110.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 522498111.

GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary

Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li

PLoS Genet. 2017 Jan; 13(1): e1006535. Published online 2017 Jan 10. doi: 10.1371/journal.pgen.1006535

PMCID:: PMC5224981

Abstract Article PDF–3.4M

Select item 493150112.

Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice

Fan Diao, Chen Jiang, Xiu-Xing Wang, Rui-Lou Zhu, Qiang Wang, Bing Yao, Chao-Jun Li

Sci Rep. 2016; 6: 28917. Published online 2016 Jul 4. doi: 10.1038/srep28917

PMCID:: PMC4931501

Abstract Article PDF–2.7M

Select item 453641513.

Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway

Weiwei Tao, Jing Wu, Bing-Xian Xie, Yuan-Yuan Zhao, Ning Shen, Shan Jiang, Xiu-Xing Wang, Na Xu, Chen Jiang, Shuai Chen, Xiang Gao, Bin Xue, Chao-Jun Li

J Biol Chem. 2015 Aug 14; 290(33): 20086–20097. Published online 2015 Jun 25. doi: 10.1074/jbc.M115.657742

PMCID:: PMC4536415

Abstract Article PDF–4.6M

Select item 451399614.

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo

Melda Şişecioğlu, Harun Budak, Lars Geffers, Murat Çankaya, Mehmet Çiftci, Christina Thaller, Gregor Eichele, Ömer İrfan Küfrevioğlu, Hasan Özdemir

J Lipid Res. 2015 Aug; 56(8): 1551–1559. doi: 10.1194/jlr.M059634

PMCID:: PMC4513996

Abstract Article PDF–3.4M

Select item 435840315.

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt

Jernej Murn, Kathi Zarnack, Yawei J. Yang, Omer Durak, Elisabeth A. Murphy, Sihem Cheloufi, Dilenny M. Gonzalez, Marianna Teplova, Tomaž Curk, Johannes Zuber, Dinshaw J. Patel, Jernej Ule, Nicholas M. Luscombe, Li-Huei Tsai, Christopher A. Walsh, Yang Shi

Genes Dev. 2015 Mar 1; 29(5): 501–512. doi: 10.1101/gad.258483.115

PMCID:: PMC4358403

Abstract Article PDF–1.4M

Select item 386164416.

Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

Shaowu Cheng, Dongfeng Cao, David A. Hottman, LiLian Yuan, Martin O. Bergo, Ling Li

J Biol Chem. 2013 Dec 13; 288(50): 35952–35960. Published online 2013 Oct 17. doi: 10.1074/jbc.M113.503904

PMCID:: PMC3861644

Abstract Article PDF–1.9M

Select item 372731717.

Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection

Xiu-Xing Wang, Pu Ying, Fan Diao, Qiang Wang, Dan Ye, Chen Jiang, Ning Shen, Na Xu, Wei-Bo Chen, Shan-Shan Lai, Shan Jiang, Xiao-Li Miao, Jin Feng, Wei-Wei Tao, Ning-Wei Zhao, Bing Yao, Zhi-Peng Xu, Hai-Xiang Sun, Jian-Min Li, Jia-Hao Sha, Xing-Xu Huang, Qing-Hua Shi, Hong Tang, Xiang Gao, Chao-Jun Li

J Exp Med. 2013 Jul 29; 210(8): 1559–1574. doi: 10.1084/jem.20121806

PMCID:: PMC3727317

Abstract Article PDF–5.0M

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317379720.

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

Xiao Yu, Ning Shen, Ming-Liang Zhang, Fei-Yan Pan, Chen Wang, Wei-Ping Jia, Chang Liu, Qian Gao, Xiang Gao, Bin Xue, Chao-Jun Li

EMBO J. 2011 Sep 14; 30(18): 3754–3765. Published online 2011 Aug 9. doi: 10.1038/emboj.2011.277

PMCID:: PMC3173797

Abstract Article PDF–1.5M

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