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Select item 99543061.

Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension

Vadim Chechekhin, Anastasia Ivanova, Konstantin Kulebyakin, Veronika Sysoeva, Daria Naida, Mikhail Arbatsky, Nataliya Basalova, Maxim Karagyaur, Mariya Skryabina, Anastasia Efimenko, Olga Grigorieva, Natalia Kalinina, Vsevolod Tkachuk, Pyotr Tyurin-Kuzmin

Cells. 2023 Feb; 12(4): 585. Published online 2023 Feb 11. doi: 10.3390/cells12040585

PMCID:: PMC9954306

Abstract Article PDF–1.9M

Select item 94092602.

Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes

Tatyana Baranova, Ekaterina Podyacheva, Tatyana Zemlyanukhina, Dmitrii Berlov, Maria Danilova, Oleg Glotov, Andrey Glotov

Int J Mol Sci. 2022 Aug; 23(16): 9433. Published online 2022 Aug 21. doi: 10.3390/ijms23169433

PMCID:: PMC9409260

Abstract Article PDF–1.5M

Select item 91063033.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 83163104.

Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers

Xianlong Gao, Garrett A. Enten, Anthony J. DeSantis, Matthias Majetschak

FEBS Lett. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: FEBS Lett. 2021 Jul; 595(14): 1863–1875. Published online 2021 Jun 11. doi: 10.1002/1873-3468.14135

PMCID:: PMC8316310

Abstract Article PDF–1.4M

Select item 83026105.

Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss

Nat Commun. 2021; 12: 4482. Published online 2021 Jul 23. doi: 10.1038/s41467-021-24825-y

PMCID:: PMC8302610

Abstract Article PDF–3.7M

Select item 82905826.

Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease

M. Archer, N. Dogra, Z. Dovey, T. Ganta, H.-S. Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Björnebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani, P. Wiklund, K. Tsao, D. J. Lundon, N. Mohamed, F. Lucien, B. Padanilam, M. Gupta, A. K. Tewari, N. Kyprianou

Cell Commun Signal. 2021; 19: 78. Published online 2021 Jul 20. doi: 10.1186/s12964-021-00755-6

PMCID:: PMC8290582

Abstract Article PDF–2.3M

Select item 79371917.

Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α₁-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays

Xianlong Gao, Garrett A. Enten, Anthony J. DeSantis, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Jul 23.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Jul 23; 528(2): 368–375. Published online 2020 Feb 19. doi: 10.1016/j.bbrc.2020.02.094

PMCID:: PMC7937191

Abstract Article PDF–1.1M

Select item 75743998.

Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma

Guoqiao Chen, Xiaoxiao Fan, Yirun Li, Lifeng He, Shanjuan Wang, Yili Dai, Cui Bin, Daizhan Zhou, Hui Lin

Epigenetics. 2020; 15(6-7): 684–701. Published online 2020 Jan 14. doi: 10.1080/15592294.2019.1709267

PMCID:: PMC7574399

Abstract Article PDF–5.7M

Select item 73220679.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 724731510.

Probing the correlation between ligand efficacy and conformational diversity at the α_1A-adrenoreceptor reveals allosteric coupling of its microswitches

Feng-Jie Wu, Lisa M. Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M. Vaid, Martina Kocan, Alice R. Whitehead, Michael D. W. Griffin, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley

J Biol Chem. 2020 May 22; 295(21): 7404–7417. Published online 2020 Apr 17. doi: 10.1074/jbc.RA120.012842

PMCID:: PMC7247315

Abstract Article PDF–2.7M

Select item 681715111.

The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo

Jianlong Han, Jinliang Zuo, Dengsong Zhu, Chunzheng Gao

J Clin Lab Anal. 2018 Jun; 32(5): e22366. Published online 2017 Dec 2. doi: 10.1002/jcla.22366

PMCID:: PMC6817151

Abstract Article PDF–313K

Select item 616668212.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 558647413.

α₁‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Lauren J. Albee, Jonathan M. Eby, Abhishek Tripathi, Heather M. LaPorte, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak

J Am Heart Assoc. 2017 Aug; 6(8): e006575. Published online 2017 Aug 17. doi: 10.1161/JAHA.117.006575

PMCID:: PMC5586474

Abstract Article PDF–2.3M

Select item 537173014.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 510526515.

A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Samantha Johnston, Donald Staines, Anne Klein, Sonya Marshall-Gradisnik

BMC Med Genet. 2016; 17: 79. Published online 2016 Nov 11. doi: 10.1186/s12881-016-0342-y

PMCID:: PMC5105265

Abstract Article PDF–431K

Select item 492650316.

New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle

Ann E. Evans, Abhishek Tripathi, Heather M. LaPorte, Lioubov I. Brueggemann, Abhay Kumar Singh, Lauren J. Albee, Kenneth L. Byron, Nadya I. Tarasova, Brian F. Volkman, Thomas Yoonsang Cho, Vadim Gaponenko, Matthias Majetschak

Int J Mol Sci. 2016 Jun; 17(6): 971. Published online 2016 Jun 20. doi: 10.3390/ijms17060971

PMCID:: PMC4926503

Abstract Article PDF–4.2M

Select item 438635217.

Heteromerization of chemokine (C-X-C motif) receptor 4 with α_1A/B-adrenergic receptors controls α₁-adrenergic receptor function

Abhishek Tripathi, P. Geoff Vana, Tanmay S. Chavan, Lioubov I. Brueggemann, Kenneth L. Byron, Nadya I. Tarasova, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak

Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13): E1659–E1668. Published online 2015 Mar 16. doi: 10.1073/pnas.1417564112

PMCID:: PMC4386352

Abstract Article PDF–1.7M

Select item 430534518.

Alpha1a-Adrenoceptor Genetic Variant Induces Cardiomyoblast to Fibroblast-like Cell Transition via Distinct Signaling Pathways

Maren Kleine-Brueggeney, Irina Gradinaru, Ekaterina Babaeva, Debra A. Schwinn, Anush Oganesian

Cell Signal. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Cell Signal. 2014 Sep; 26(9): 1985–1997. Published online 2014 May 15. doi: 10.1016/j.cellsig.2014.05.007

PMCID:: PMC4305345

Abstract Article PDF–1.1M

Select item 430162919.

Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway

Alicja. J. Copik, Aleksander Baldys, Khanh Nguyen, Sunil Sahdeo, Hoangdung Ho, Alan Kosaka, Paul J. Dietrich, Bill Fitch, John R. Raymond, Anthony P. D. W. Ford, Donald Button, Marcos E. Milla

PLoS One. 2015; 10(1): e0115701. Published online 2015 Jan 21. doi: 10.1371/journal.pone.0115701

PMCID:: PMC4301629

Abstract Article PDF–5.9M

Select item 406425420.

An atlas of genetic influences on human blood metabolites

So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo

Nat Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982

PMCID:: PMC4064254

Abstract Article PDF–2.4M

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