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Select item 110720301.

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

Ravit Malishev, Shani Ben-Zichri, Ofek Oren, Nitzan Shauloff, Tal Peretz, Ran Taube, Niv Papo, Raz Jelinek

Cell Mol Life Sci. 2021 Mar; 78(5): 2145–2155. Published online 2020 Aug 25. doi: 10.1007/s00018-020-03623-7

PMCID:: PMC11072030

Abstract Article PDF–5.1M

Select item 108081152.

Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway

Mitsuo Matsumoto, Naomi Ogawa, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Jitsuo Usuda

Sci Rep. 2024; 14: 2130. Published online 2024 Jan 25. doi: 10.1038/s41598-024-52616-0

PMCID:: PMC10808115

Abstract Article PDF–3.8M

Select item 107817793.

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Rebekka Lambrecht, Franziska Rudolf, Anna-Katharina Ückert, Valentina C. Sladky, Truong San Phan, Jasmin Jansen, Samara Naim, Thomas Kaufmann, Adrian Keogh, Susanne Kirschnek, Aswin Mangerich, Florian Stengel, Marcel Leist, Andreas Villunger, Thomas Brunner

Cell Death Differ. 2024 Jan; 31(1): 119–131. Published online 2023 Nov 24. doi: 10.1038/s41418-023-01245-7

PMCID:: PMC10781779

Abstract Article PDF–8.1M

Select item 107191474.

Ectopic BH3-Only Protein Bim Associates with Hsp70 to Regulate Yeast Mitophagy

Linjie Yuan, Yuying Wang, B. A. Margulis, Ting Song, Ziqian Wang, Zhichao Zhang

Dokl Biochem Biophys. 2023; 512(1): 292–299. Published online 2023 Dec 13. doi: 10.1134/S1607672923700485

PMCID:: PMC10719147

Abstract Article PDF–1.0M

Select item 92760025.

Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis

Hecheng Wang, Shusen Lin, Yujie Yang, Mingyu Zhao, Xichun Li, Lanli Zhang

Bioengineered. 2022; 13(5): 13728–13738. Published online 2022 Jun 15. doi: 10.1080/21655979.2022.2080412

PMCID:: PMC9276002

Abstract Article PDF–5.6M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 92563367.

MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11

Mingyu Xiu, Hengfei Luan, Xiaojiao Gu, Chuang Liu, Deming Xu

Comput Math Methods Med. 2022; 2022: 6018037. Published online 2022 Jun 28. doi: 10.1155/2022/6018037

PMCID:: PMC9256336

Abstract Article PDF–1.8M

Select item 88637738.

The deubiquitinase Usp27x as a novel regulator of cFLIP_L protein expression and sensitizer to death-receptor-induced apoptosis

Manuel Nico Dold, Xiulin Ng, Claudia Alber, Ian Edward Gentle, Georg Häcker, Arnim Weber

Apoptosis. 2022; 27(1-2): 112–132. Published online 2022 Jan 19. doi: 10.1007/s10495-021-01706-9

PMCID:: PMC8863773

Abstract Article PDF–2.7M

Select item 87427679.

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-X_L–Specific Degrader DT2216

Dinesh Thummuri, Sajid Khan, Patrick W. Underwood, Peiyi Zhang, Janet Wiegand, Xuan Zhang, Vivekananda Budamagunta, Amin Sobh, Abderrahmane Tagmount, Alexander Loguinov, Andrea N. Riner, Ashwin S. Akki, Elizabeth Williamson, Robert Hromas, Christopher D. Vulpe, Guangrong Zheng, Jose G. Trevino, Daohong Zhou

Mol Cancer Ther. 2022 Jan 1; 21(1): 184–192. Published online 2021 Oct 19. doi: 10.1158/1535-7163.MCT-21-0474

PMCID:: PMC8742767

Abstract Article PDF–1.2M

Select item 855198010.

Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis

Fangfang Lv, Liang Sun, Qiuping Yang, Zheng Pan, Yuhua Zhang

Biomed Res Int. 2021; 2021: 3621828. Published online 2021 Oct 13. doi: 10.1155/2021/3621828

PMCID:: PMC8551980

Abstract Article PDF–635K

Select item 817157711.

Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer

BO WOOK KIM, HANBYOUL CHO, KRIS YLAYA, HARUHISA KITANO, JOON-YONG CHUNG, STEPHEN M. HEWITT, JAE-HOON KIM

Anticancer Res. Author manuscript; available in PMC 2021 Jun 2.

Published in final edited form as: Anticancer Res. 2017 Sep; 37(9): 4873–4879. doi: 10.21873/anticanres.11896

PMCID:: PMC8171577

Abstract Article PDF–775K

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 814151513.

FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

Ruiqi Zhu, Li Li, Bao Nguyen, Jaesung Seo, Min Wu, Tessa Seale, Mark Levis, Amy Duffield, Yu Hu, Donald Small

Signal Transduct Target Ther. 2021; 6: 186. Published online 2021 May 24. doi: 10.1038/s41392-021-00578-4

PMCID:: PMC8141515

Abstract Article PDF–3.6M

Select item 802943814.

MiR‐124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

Huiqing Wang, Yongyi Ye, Zhiyuan Zhu, Liqian Mo, Chunnan Lin, Qifu Wang, Haoyuan Wang, Xin Gong, Xiaozheng He, Guohui Lu, Fengfei Lu, Shizhong Zhang

Brain Pathol. 2016 Mar; 26(2): 167–176. Published online 2015 Jun 11. doi: 10.1111/bpa.12267

PMCID:: PMC8029438

Abstract Article PDF–576K

Select item 788926415.

Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer

João Fevereiro, Alexandra G. Fraga, Carlos Capela, Ghislain E. Sopoh, Ange Dossou, Gilbert Adjimon Ayelo, Maria João Peixoto, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa

Emerg Microbes Infect. 2021; 10(1): 223–225. Published online 2021 Feb 11. doi: 10.1080/22221751.2021.1878936

PMCID:: PMC7889264

Abstract Article PDF–490K

Select item 778005416.

Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non‐small cell lung cancer

Yu Wakabayashi, Takeshi Masuda, Kazunori Fujitaka, Taku Nakashima, Joe Okumoto, Kiyofumi Shimoji, Yoshifumi Nishimura, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Hironobu Hamada, Noboru Hattori

Cancer Sci. 2021 Jan; 112(1): 369–379. Published online 2020 Nov 12. doi: 10.1111/cas.14711

PMCID:: PMC7780054

Abstract Article PDF–1.1M

Select item 753351517.

MicroRNA-25-3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim

Zhifang Zhao, Jie Zheng, Youchen Ye, Kefeng Zhao, Ruozhang Wang, Ran Wang

Mol Med Rep. 2020 Nov; 22(5): 3621–3628. Published online 2020 Sep 2. doi: 10.3892/mmr.2020.11483

PMCID:: PMC7533515

Abstract Article PDF–843K

Select item 748991218.

The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients

Zongwei Guo, Ting Song, Ziqian Wang, Donghai Lin, Keke Cao, Peng Liu, Yingang Feng, Xiaodong Zhang, Peiran Wang, Fangkui Yin, Jian Dai, Sheng Zhou, Zhichao Zhang

J Biol Chem. 2020 Sep 11; 295(37): 12900–12909. Published online 2020 Jul 10. doi: 10.1074/jbc.RA120.013364

PMCID:: PMC7489912

Abstract Article PDF–2.2M

Select item 748140419.

PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2

Hengxing Chen, Yun Li, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H. Phillip Koeffler, Wenjing Wu, Kaishun Hu, Dong Yin

Theranostics. 2020; 10(22): 9984–10000. Published online 2020 Aug 8. doi: 10.7150/thno.47044

PMCID:: PMC7481404

Abstract Article PDF–4.0M

Select item 737115120.

Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J. Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, Reuben Kapur

Cell Rep. Author manuscript; available in PMC 2020 Jul 20.

Published in final edited form as: Cell Rep. 2020 Jun 23; 31(12): 107816. doi: 10.1016/j.celrep.2020.107816

PMCID:: PMC7371151

Abstract Article PDF–2.4M

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