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Items: 1 to 20 of 239

1.
TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling
Jianling Xie, Stuart P. De Poi, Sean J. Humphrey, Leanne K. Hein, John B. Bruning, Wenru Pan, Luke A. Selth, Timothy J. Sargeant, Christopher G. Proud
Cell Mol Life Sci. 2021 Apr; 78(8): 4035–4052. Published online 2021 Apr 8. doi: 10.1007/s00018-021-03825-7
PMCID:
PMC11072378
AbstractArticlePDF–5.3M
2.
Comparative interactome analysis of α-arrestin families in human and Drosophila
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam
eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328
PMCID:
PMC10945707
AbstractArticlePDF–2.8M
3.
CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling
Wei-Ting Liao, Yun-Jung Chiang, Hsin-Fang Yang-Yen, Li-Chung Hsu, Zee-Fen Chang, Jeffrey J.Y. Yen
J Biol Chem. 2023 Dec; 299(12): 105455. Published online 2023 Nov 8. doi: 10.1016/j.jbc.2023.105455
Correction in:
J Biol Chem. 2024 Feb; 300(2): 105686.
PMCID:
PMC10698277
AbstractArticlePDF–2.9M
4.
Non-canonical functions of a mutant TSC2 protein in mitotic division
Mary-Bronwen L. Chalkley, Rachel B. Mersfelder, Maria Sundberg, Laura C. Armstrong, Mustafa Sahin, Rebecca A. Ihrie, Kevin C. Ess
PLoS One. 2023; 18(10): e0292086. Published online 2023 Oct 4. doi: 10.1371/journal.pone.0292086
PMCID:
PMC10550124
AbstractArticlePDF–1.3M
5.
Design of negative‐regulating proteins of Rheb/mTORC1 with much‐reduced sizes of the tuberous sclerosis protein complex
Wencheng Fu, Geng Wu
Protein Sci. 2023 Aug; 32(8): e4731. Published online 2023 Aug 1. doi: 10.1002/pro.4731
PMCID:
PMC10382911
AbstractArticlePDF–6.4M
6.
Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population
Juan He, Shengyuan Liu, Xujun Guo, Fan Zhang, Yuzheng Fan, Lijuan Wu, Howard Eugene Takiff, Yashuang Zhao
Rev Soc Bras Med Trop. 2023; 56: e0104-2023. Published online 2023 Jul 24. doi: 10.1590/0037-8682-0104-2023
PMCID:
PMC10367219
AbstractArticlePDF–1.1M
7.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
8.
mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer
Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen
JCI Insight. 2023 Mar 8; 8(5): e156657. Published online 2023 Mar 8. doi: 10.1172/jci.insight.156657
PMCID:
PMC10077471
AbstractArticlePDF–7.2M
9.
TSC2 Loss in Lymphangioleiomyomatosis Cells Correlated with Expression of CD44v6, a Molecular Determinant of Metastasis
Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Denise M. Crooks, Linda A. Stevens, Hiroshi Hashimoto, Shaowei Li, Ji-an Wang, Thomas N. Darling, Joel Moss
Cancer Res. Author manuscript; available in PMC 2023 Apr 3.
Published in final edited form as: Cancer Res. 2007 Nov 1; 67(21): 10573–10581. doi: 10.1158/0008-5472.CAN-07-1356
PMCID:
PMC10068840
AbstractArticlePDF–2.8M
10.
TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling
Chun‐Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peeper
EMBO J. 2023 Mar; 42(5): e111614. Published online 2023 Jan 30. doi: 10.15252/embj.2022111614
PMCID:
PMC9975943
AbstractArticlePDF–2.7M
11.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini
Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3
PMCID:
PMC9950183
AbstractArticlePDF–2.4M
12.
Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study
Soyoung Ryu, Hoon-Chul Kang, Sung Chul Lee, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Yonsei Med J. 2023 Feb; 64(2): 133–138. Published online 2023 Jan 18. doi: 10.3349/ymj.2022.0451
PMCID:
PMC9892541
AbstractArticlePDF–622K
13.
Crosstalk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
Yuanjun Shen, Dmitry A. Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E. Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L. Mora, Tatiana V. Kudryashova, Elena. A. Goncharova
Sci Signal. Author manuscript; available in PMC 2023 Dec 6.
Published in final edited form as: Sci Signal. 2022 Dec 6; 15(763): eabn2743. Published online 2022 Dec 6. doi: 10.1126/scisignal.abn2743
PMCID:
PMC9869933
AbstractArticlePDF–3.1M
14.
Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity
Jennifer M. Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R. Shen, Valeria Cavalli, Erica L. Scheller
Mol Metab. 2023 Feb; 68: 101664. Published online 2022 Dec 28. doi: 10.1016/j.molmet.2022.101664
PMCID:
PMC9841058
AbstractArticlePDF–5.0M
15.
Concurrent Reduced Expression of Contiguous PKD1, TSC2 and NTHL1 Leading to Kidney Diseases and Multiple Diverse Renal Cancers
SATORU MEGURO, TOMOYUKI KOGUCHI, YUSUKE HAKOZAKI, AKIFUMI ONAGI, KANAKO MATSUOKA, SEIJI HOSHI, JUNYA HATA, YUICHI SATO, HIDENORI AKAIHATA, MASAO KATAOKA, SOICHIRO OGAWA, YOSHIYUKI KOJIMA
Cancer Genomics Proteomics. 2023 Jan-Feb; 20(1): 40–50. Published online 2023 Jan 3. doi: 10.21873/cgp.20363
PMCID:
PMC9806674
AbstractArticlePDF–5.1M
16.
Gene mutations in sporadic lymphangioleiomyomatosis and genotype–phenotype correlation analysis
Jiannan Huang, Wenshuai Xu, Peng Liu, Yaping Liu, Cheng Shen, Song Liu, Yani Wang, Jun Wang, Tengyue Zhang, Yudi He, Chongsheng Cheng, Luning Yang, Weihong Zhang, Xinlun Tian, Kai-Feng Xu
BMC Pulm Med. 2022; 22: 354. Published online 2022 Sep 18. doi: 10.1186/s12890-022-02154-0
PMCID:
PMC9482747
AbstractArticlePDF–1.0M
17.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
18.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
19.
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth
Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A. Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D’Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello
Commun Biol. 2022; 5: 780. Published online 2022 Aug 2. doi: 10.1038/s42003-022-03639-8
Correction in:
Commun Biol. 2024; 7: 1411.
PMCID:
PMC9345969
AbstractArticlePDF–2.3M
20.
Low‐level mosaicism in tuberous sclerosis complex in four unrelated patients: Comparison of clinical characteristics and diagnostic pathways
Héctor Hugo Manzanilla‐Romero, Denisa Weis, Simon Schnaiter, Sabine Rudnik‐Schöneborn
Am J Med Genet A. 2021 Dec; 185(12): 3851–3858. Published online 2021 Jul 30. doi: 10.1002/ajmg.a.62433
PMCID:
PMC9291125
AbstractArticlePDF–1.7M

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