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Select item 111598131.

BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization

Junichi Shigeta, Kazuhiro Katayama, Junko Mitsuhashi, Kohji Noguchi, Yoshikazu Sugimoto

Cancer Sci. 2010 Aug; 101(8): 1813–1821. Published online 2010 Apr 28. doi: 10.1111/j.1349-7006.2010.01605.x

PMCID:: PMC11159813

Abstract Article PDF–645K

Select item 105843452.

BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis

Rebeca Uceda-Castro, Andreia S. Margarido, Ji-Ying Song, Mark C. de Gooijer, Hendrik A. Messal, Cecilia R. Chambers, Max Nobis, Ceren H. Çitirikkaya, Kerstin Hahn, Danielle Seinstra, David Herrmann, Paul Timpson, Pieter Wesseling, Olaf van Tellingen, Claire Vennin, Jacco van Rheenen

Sci Adv. 2023 Oct 20; 9(42): eabp9530. Published online 2023 Oct 18. doi: 10.1126/sciadv.abp9530

PMCID:: PMC10584345

Abstract Article PDF–2.3M

Select item 104976853.

Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine

Sahar A. Harby, Nehal A. Khalil, Norhan S. El-Sayed, Eman H. Thabet, Samar R. Saleh, Mona Hassan Fathelbab

Naunyn Schmiedebergs Arch Pharmacol. 2023; 396(10): 2627–2636. Published online 2023 Apr 17. doi: 10.1007/s00210-023-02485-7

PMCID:: PMC10497685

Abstract Article PDF–1.3M

Select item 101906754.

Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin

Esther Blanco-Paniagua, Laura Álvarez-Fernández, Andrea Rodríguez-Alonso, Alicia Millán-Garcia, Ana I. Álvarez, Gracia Merino

Antimicrob Agents Chemother. 2023 May; 67(5): e00095-23. Published online 2023 Apr 20. doi: 10.1128/aac.00095-23

PMCID:: PMC10190675

Abstract Article PDF–354K

Select item 100783635.

ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites

Laura Álvarez‐Fernández, Alex Gomez‐Gomez, Noemí Haro, Alba M. García‐Lino, Ana I. Álvarez, Oscar J. Pozo, Gracia Merino

J Pineal Res. 2023 Mar; 74(2): e12849. Published online 2022 Dec 31. doi: 10.1111/jpi.12849

PMCID:: PMC10078363

Abstract Article PDF–1.9M

Select item 98312786.

ATP BINDING CASSETTE SUB-FAMILY MEMBER 2 (ABCG2) AND XENOBIOTIC EXPOSURE DURING EARLY MOUSE EMBRYONIC STEM CELL DIFFERENTIATION

Mitchell B. Rosen, Susan C. Jeffay, Harriette P. Nichols, Maria R. Hoopes, E. Sidney Hunter, III.

Birth Defects Res. Author manuscript; available in PMC 2023 Jan 10.

Published in final edited form as: Birth Defects Res. 2018 Jan 15; 110(1): 35–47. Published online 2017 Oct 9. doi: 10.1002/bdr2.1114

PMCID:: PMC9831278

Abstract Article PDF–2.2M

Select item 85808927.

Modulation of Placental Breast Cancer Resistance Protein by HDAC1 in Mice: Implications for Optimization of Pharmacotherapy During Pregnancy

Chuan Wang, Dan Ma, Yimin Hua, Hongyu Duan

Reprod Sci. 2021 Dec; 28(12): 3540–3546. Published online 2021 Oct 19. doi: 10.1007/s43032-021-00773-2

PMCID:: PMC8580892

Abstract Article PDF–4.6M

Select item 72929638.

ABCG2 Deficiency Does Not Alter Dolutegravir Metabolism and Pharmacokinetics

Junjie Zhu, Xin Tian, Amina I. Shehu, Deborah K. McMahon, Xiaochao Ma

J Pharmacol Exp Ther. 2020 Jul; 374(1): 38–43. Published online 2020 Jul. doi: 10.1124/jpet.119.264424

PMCID:: PMC7292963

Abstract Article PDF–568K

Select item 72655409.

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward

Nat Commun. 2020; 11: 2767. Published online 2020 Jun 2. doi: 10.1038/s41467-020-16525-w

PMCID:: PMC7265540

Abstract Article PDF–7.9M

Select item 720064410.

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

Bojana Ristic, Sathish Sivaprakasam, Monisha Narayanan, Vadivel Ganapathy

Biochem J. 2020 Apr 30; 477(8): 1499–1513. Prepublished online 2020 Apr 2. Published online 2020 Apr 29. doi: 10.1042/BCJ20190873

PMCID:: PMC7200644

Abstract Article PDF–6.1M

Select item 713614911.

Abcg2-Expressing Side Population Cells Contribute to Cardiomyocyte Renewal through Fusion

Amritha Yellamilli, Yi Ren, Ron T. McElmurry, Jonathan P. Lambert, Polina Gross, Sadia Mohsin, Steven R. Houser, John W. Elrod, Jakub Tolar, Daniel J. Garry, Jop H. van Berlo

FASEB J. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: FASEB J. 2020 Apr; 34(4): 5642–5657. Published online 2020 Feb 25. doi: 10.1096/fj.201902105R

PMCID:: PMC7136149

Abstract Article PDF–2.2M

Select item 687993912.

Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney

Leslie S. Gewin, Megan E. Summers, Julie W. Harral, Christa F. Gaskill, Stellor Nlandu Khodo, Surekha Neelisetty, Timothy M. Sullivan, Katharina Hopp, J. Jeffrey Reese, Dwight J. Klemm, Valentina Kon, Kevin C. Ess, Wei Shi, Susan M. Majka

Am J Physiol Renal Physiol. 2019 Nov 1; 317(5): F1201–F1210. Published online 2019 Aug 28. doi: 10.1152/ajprenal.00629.2018

PMCID:: PMC6879939

Abstract Article

Select item 675481213.

Brain Region-Specific Regulation of Histone Acetylation and Efflux Transporters in Mice

Dahea You, Hye Min Shin, Fatimah Mosaad, Jason R. Richardson, Lauren M. Aleksunes

J Biochem Mol Toxicol. Author manuscript; available in PMC 2020 Jun 5.

Published in final edited form as: J Biochem Mol Toxicol. 2019 Jun; 33(6): e22318. Published online 2019 Mar 21. doi: 10.1002/jbt.22318

PMCID:: PMC6754812

Abstract Article PDF–782K

Select item 675091214.

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria

Pengcheng Wang, Madhav Sachar, Jie Lu, Amina I. Shehu, Junjie Zhu, Jing Chen, Ke Liu, Karl E. Anderson, Wen Xie, Frank J. Gonzalez, Curtis D. Klaassen, Xiaochao Ma

Sci Adv. 2019 Sep; 5(9): eaaw6127. Published online 2019 Sep 18. doi: 10.1126/sciadv.aaw6127

PMCID:: PMC6750912

Abstract Article PDF–4.1M

Select item 662089215.

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

Karthika Natarajan, Yi Xie, Takeo Nakanishi, Rebecca S. Moreci, Pancharatnam Jeyasuria, Arif Hussain, Douglas D. Ross

J Vis Exp. 2016; (111): 53827. Published online 2016 May 27. doi: 10.3791/53827

PMCID:: PMC6620892

Abstract Article PDF–166K

Select item 640873616.

Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice

Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria, William F. Elmquist

Drug Metab Dispos. 2019 Apr; 47(4): 393–404. Published online 2019 Apr. doi: 10.1124/dmd.118.084210

PMCID:: PMC6408736

Abstract Article PDF–1.2M

Select item 605795917.

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression

T. Takada, T. Yamamoto, H. Matsuo, J. K. Tan, K. Ooyama, M. Sakiyama, H. Miyata, Y. Yamanashi, Y. Toyoda, T. Higashino, A. Nakayama, A. Nakashima, N. Shinomiya, K. Ichida, H. Ooyama, S. Fujimori, H. Suzuki

Sci Rep. 2018; 8: 11147. Published online 2018 Jul 24. doi: 10.1038/s41598-018-29208-w

PMCID:: PMC6057959

Abstract Article PDF–1.0M

Select item 577402718.

Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior

Samantha J. Hindle, Roeben N. Munji, Elena Dolghih, Garrett Gaskins, Souvinh Orng, Hiroshi Ishimoto, Allison Soung, Michael DeSalvo, Toshihiro Kitamoto, Michael J. Keiser, Matthew P. Jacobson, Richard Daneman, Roland J. Bainton

Cell Rep. Author manuscript; available in PMC 2018 Jan 19.

Published in final edited form as: Cell Rep. 2017 Oct 31; 21(5): 1304–1316. doi: 10.1016/j.celrep.2017.10.026