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Select item 86432551.

Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation

Wenjun Zeng, Yinan Ji, Haiping Zhang, Liusheng Chen, Li Du, Ruiwei Guo

Genet Res (Camb) 2021; 2021: 2949986. Published online 2021 Nov 27. doi: 10.1155/2021/2949986

PMCID:: PMC8643255

Abstract Article PDF–1.1M

Select item 82318922.

Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma

Osama M. Elzamzamy, Brandon E. Johnson, Wei-Chih Chen, Gangqing Hu, Reinhold Penner, Lori A. Hazlehurst

Cells. 2021 Jun; 10(6): 1490. Published online 2021 Jun 13. doi: 10.3390/cells10061490

PMCID:: PMC8231892

Abstract Article PDF–5.3M

Select item 82077043.

Involvement of TRPC5 Channels, Inwardly Rectifying K⁺ channels, PLCβ and PIP₂ in Vasopressin-mediated Excitation of Medial Central Amygdala Neurons

Cody A. Boyle, Binqi Hu, Kati L. Quaintance, Saobo Lei

J Physiol. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: J Physiol. 2021 Jun; 599(12): 3101–3119. Published online 2021 Apr 27. doi: 10.1113/JP281260

PMCID:: PMC8207704

Abstract Article PDF–1.3M

Select item 81913104.

PIP₂ regulation of TRPC5 channel activation and desensitization

Mehek Ningoo, Leigh D. Plant, Anna Greka, Diomedes E. Logothetis

J Biol Chem. 2021 Jan-Jun; 296: 100726. Published online 2021 Apr 30. doi: 10.1016/j.jbc.2021.100726

PMCID:: PMC8191310

Abstract Article PDF–2.8M

Select item 79873485.

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

Kangcheng Song, Miao Wei, Wenjun Guo, Li Quan, Yunlu Kang, Jing-Xiang Wu, Lei Chen

eLife. 2021; 10: e63429. Published online 2021 Mar 8. doi: 10.7554/eLife.63429

PMCID:: PMC7987348

Abstract Article PDF–3.5M

Select item 71405306.

Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis

Jizheng Guo, Jie Li, Lin Xia, Yang Wang, Jinhang Zhu, Juan Du, Yungang Lu, Guodong Liu, Xiaoqiang Yao, Bing Shen

Cells. 2020 Mar; 9(3): 547. Published online 2020 Feb 26. doi: 10.3390/cells9030547

PMCID:: PMC7140530

Abstract Article PDF–4.0M

Select item 63727167.

Differential PI(4,5)P₂ sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels

Juyeon Ko, Jongyun Myeong, Young-Cheul Shin, Insuk So

Sci Rep. 2019; 9: 1849. Published online 2019 Feb 12. doi: 10.1038/s41598-018-38443-0

PMCID:: PMC6372716

Abstract Article PDF–4.9M

Select item 60923948.

Dual action of the Gα_q-PLCβ-PI(4,5)P₂ pathway on TRPC1/4 and TRPC1/5 heterotetramers

Jongyun Myeong, Juyeon Ko, Misun Kwak, Jinsung Kim, Joohan Woo, Kotdaji Ha, Chansik Hong, Dongki Yang, Hyun Jin Kim, Ju-Hong Jeon, Insuk So

Sci Rep. 2018; 8: 12117. Published online 2018 Aug 14. doi: 10.1038/s41598-018-30625-0

PMCID:: PMC6092394

Abstract Article PDF–3.5M

Select item 58196899.

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-fang Jin, Dong Hua

BMC Cancer. 2018; 18: 207. Published online 2018 Feb 20. doi: 10.1186/s12885-018-4123-1

PMCID:: PMC5819689

Abstract Article PDF–2.6M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 546665511.

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway

Peng Zhang, Xiaoyu Liu, Hongjuan Li, Zhen Chen, Xiaoqiang Yao, Jian Jin, Xin Ma

Sci Rep. 2017; 7: 3158. Published online 2017 Jun 9. doi: 10.1038/s41598-017-03230-w

PMCID:: PMC5466655

Abstract Article PDF–3.4M

Select item 543722512.

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Hussein N. Rubaiy, Melanie J. Ludlow, Matthias Henrot, Hannah J. Gaunt, Katarina Miteva, Sin Ying Cheung, Yasuyuki Tanahashi, Nurasyikin Hamzah, Katie E. Musialowski, Nicola M. Blythe, Hollie L. Appleby, Marc A. Bailey, Lynn McKeown, Roger Taylor, Richard Foster, Herbert Waldmann, Peter Nussbaumer, Mathias Christmann, Robin S. Bon, Katsuhiko Muraki, David J. Beech

J Biol Chem. 2017 May 19; 292(20): 8158–8173. Published online 2017 Mar 21. doi: 10.1074/jbc.M116.773556

PMCID:: PMC5437225

Abstract Article PDF–3.8M

Select item 537826913.

Increasing circulating exosomes‐carrying TRPC5 predicts chemoresistance in metastatic breast cancer patients

Teng Wang, Kuan Ning, Ting‐xun Lu, Xu Sun, Linfang Jin, Xiaowei Qi, Jian Jin, Dong Hua

Cancer Sci. 2017 Mar; 108(3): 448–454. Published online 2017 Apr 3. doi: 10.1111/cas.13150

PMCID:: PMC5378269

Abstract Article PDF–522K

Select item 526423414.

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation

Khadija M Alawi, Fiona A Russell, Aisah A Aubdool, Salil Srivastava, Yanira Riffo-Vasquez, Lineu Baldissera, Jr, Pratish Thakore, Nurjahan Saleque, Elizabeth S Fernandes, David A Walsh, Susan D Brain

Ann Rheum Dis. 2017 Jan; 76(1): 252–260. Published online 2016 May 10. doi: 10.1136/annrheumdis-2015-208886

PMCID:: PMC5264234

Abstract Article PDF–2.9M

Select item 524766215.

Molecular Determinants of the Sensitivity to G_q/11-Phospholipase C-dependent Gating, Gd³⁺ Potentiation, and Ca²⁺ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

Xingjuan Chen, Wennan Li, Ashley M. Riley, Mario Soliman, Saikat Chakraborty, Christopher W. Stamatkin, Alexander G. Obukhov

J Biol Chem. 2017 Jan 20; 292(3): 898–911. Published online 2016 Dec 5. doi: 10.1074/jbc.M116.755470

PMCID:: PMC5247662

Abstract Article PDF–4.6M

Select item 444721616.

TRUSS, TNF-R1, and TRPC Ion Channels Synergistically Reverse Endoplasmic Reticulum Ca²⁺ Storage Reduction in Response to m1 Muscarinic Acetylcholine Receptor Signaling

Kimberly E. Mace, Marc P. Lussier, Guylain Boulay, Jennifer L. Terry-Powers, Helen Parfrey, Anne-Laure Perraud, David W.H. Riches

J Cell Physiol. Author manuscript; available in PMC 2015 May 28.

Published in final edited form as: J Cell Physiol. 2010 Nov; 225(2): 444–453. doi: 10.1002/jcp.22221

PMCID:: PMC4447216

Abstract Article PDF–3.3M

Select item 428174617.

Inhibition of Transient Receptor Potential Channel 5 Reverses 5-Fluorouracil Resistance in Human Colorectal Cancer Cells

Teng Wang, Zhen Chen, Yifei Zhu, Qiongxi Pan, Yanjun Liu, Xiaowei Qi, Linfang Jin, Jian Jin, Xin Ma, Dong Hua

J Biol Chem. 2015 Jan 2; 290(1): 448–456. Published online 2014 Nov 17. doi: 10.1074/jbc.M114.590364

PMCID:: PMC4281746

Abstract Article PDF–1.5M

Select item 403592318.

Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance

Xin Ma, Zhen Chen, Dong Hua, Dongxu He, Linjun Wang, Peng Zhang, Junqi Wang, Yanfei Cai, Caiji Gao, Xiaodong Zhang, Fangfang Zhang, Teng Wang, Tingting Hong, Linfang Jin, Xiaowei Qi, Shuxian Chen, Xiaoting Gu, Dangtong Yang, Qiongxi Pan, Yifei Zhu, Yun Chen, Daozhen Chen, Liwen Jiang, Xiaofeng Han, Yanyun Zhang, Jian Jin, Xiaoqiang Yao

Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17): 6389–6394. Published online 2014 Apr 14. doi: 10.1073/pnas.1400272111

PMCID:: PMC4035923

Abstract Article PDF–2.0M

Select item 387470419.

Riluzole activates TRPC5 channels independently of PLC activity

Julia M Richter, Michael Schaefer, Kerstin Hill

Br J Pharmacol. 2014 Jan; 171(1): 158–170. Published online 2013 Dec 10. doi: 10.1111/bph.12436

PMCID:: PMC3874704

Abstract Article PDF–1.8M

Select item 370765020.

Conserved Gating Elements in TRPC4 and TRPC5 Channels

Andreas Beck, Tilman Speicher, Christof Stoerger, Thomas Sell, Viviane Dettmer, Siti A. Jusoh, Ammar Abdulmughni, Adolfo Cavalié, Stephan E. Philipp, Michael X. Zhu, Volkhard Helms, Ulrich Wissenbach, Veit Flockerzi

J Biol Chem. 2013 Jul 5; 288(27): 19471–19483. Published online 2013 May 15. doi: 10.1074/jbc.M113.478305

PMCID:: PMC3707650

Abstract Article PDF–4.6M

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