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Select item 109017371.

On the genetic basis of tail-loss evolution in humans and apes

Bo Xia, Weimin Zhang, Guisheng Zhao, Xinru Zhang, Jiangshan Bai, Ran Brosh, Aleksandra Wudzinska, Emily Huang, Hannah Ashe, Gwen Ellis, Maayan Pour, Yu Zhao, Camila Coelho, Yinan Zhu, Alexander Miller, Jeremy S. Dasen, Matthew T. Maurano, Sang Y. Kim, Jef D. Boeke, Itai Yanai

Nature. 2024; 626(8001): 1042–1048. Published online 2024 Feb 28. doi: 10.1038/s41586-024-07095-8

PMCID:: PMC10901737

Abstract Article PDF–5.7M

Select item 88288952.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 87614243.

Association between TBXT rs2305089 polymorphism and chordoma in Iranian patients identified by a developed T‐ARMS‐PCR assay

Maryam Jalessi, Mohammad Saeed Gholami, Ehsan Razmara, Sajad Hassanzadeh, Alireza Sadeghipour, Amin Jahanbakhshi, Alireza Tabibkhooei, Eshagh Bahrami, Masoumeh Falah

J Clin Lab Anal. 2022 Jan; 36(1): e24150. Published online 2021 Nov 27. doi: 10.1002/jcla.24150

PMCID:: PMC8761424

Abstract Article PDF–1001K

Select item 85112004.

Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial Chordoma: A clinicopathological and molecular analysis

Xiaoyun Wen, Robert Cimera, Ruth Aryeequaye, Mohanty Abhinta, Edward Athanasian, John Healey, Nicola Fabbri, Patrick Boland, Yanming Zhang, Meera Hameed

Genes Chromosomes Cancer. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Genes Chromosomes Cancer. 2021 Dec; 60(12): 796–807. Published online 2021 Aug 26. doi: 10.1002/gcc.22992

PMCID:: PMC8511200

Abstract Article PDF–3.0M

Select item 83608365.

miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion

Qin Ye, Xing Wang, Mei Yuan, Shuaishuai Cui, Yuanyuan Chen, Zhaodi Hu, Dandan Liu, Conghui Han, Bibo Li, Dahu Chen

Biosci Rep. 2021 Aug 27; 41(8): BSR20210318. Published online 2021 Aug 12. doi: 10.1042/BSR20210318

PMCID:: PMC8360836

Abstract Article PDF–1.1M

Select item 80248746.

Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer

Kaichun Li, Qiaoyun Wang, Yanyan Lu, Xiaorong Pan, Long Liu, Shiyu Cheng, Bingxiang Wu, Zongchang Song, Wei Gao

Biosci Rep. 2021 Apr 30; 41(4): BSR20203391. Published online 2021 Apr 6. doi: 10.1042/BSR20203391

PMCID:: PMC8024874

Abstract Article PDF–1.1M

Select item 80090487.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 78512328.

Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide

Filipe Pinto, Ângela M. Costa, Raquel P. Andrade, Rui Manuel Reis

Neurotherapeutics. 2020 Oct; 17(4): 2015–2027. Published online 2020 Aug 12. doi: 10.1007/s13311-020-00911-9

PMCID:: PMC7851232

Abstract Article PDF–5.9M

Select item 78178749.

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Hadley E. Sheppard, Alessandra Dall’Agnese, Woojun D. Park, M. Hamza Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia Cogswell, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias J. Wawer, Behnam Nabet, Nathanael S. Gray, Paul A. Clemons, Stuart L. Schreiber, Paul Workman, Richard A. Young, Charles Y. Lin

Cell Rep Med. 2021 Jan 19; 2(1): 100188. Published online 2021 Jan 19. doi: 10.1016/j.xcrm.2020.100188

PMCID:: PMC7817874

Abstract Article PDF–14M

Select item 693838810.

Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma

MJ Kelley, J Shi, B Ballew, PL Hyland, WQ Li, M Rotunno, DA Alcorta, NJ Liebsch, J Mitchell, S Bass, D Roberson, J Boland, M Cullen, J He, L Burdette, M Yeager, SJ Chanock, DM Parry, AM Goldstein, XR Yang

Hum Genet. Author manuscript; available in PMC 2019 Dec 31.

Published in final edited form as: Hum Genet. 2014 Oct; 133(10): 1289–1297. Published online 2014 Jul 4. doi: 10.1007/s00439-014-1463-z

PMCID:: PMC6938388

Abstract Article PDF–353K

Select item 627503811.

Transfection of T-Box Transcription Factor BRACHYURY and SOX2 Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells

Naonari Akimoto, Kodai Nakamura, Hiroshi Hijioka, Kenichi Kume, Yoshiaki Matsumura, Tsuyoshi Sugiura

Int J Mol Sci. 2018 Nov; 19(11): 3620. Published online 2018 Nov 16. doi: 10.3390/ijms19113620

PMCID:: PMC6275038

Abstract Article PDF–4.5M

Select item 608934512.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma

Andrew C Nelson, Nischalan Pillay, Stephen Henderson, Nadège Presneau, Roberto Tirabosco, Dina Halai, Fitim Berisha, Paul Flicek, Derek L Stemple, Claudio D Stern, Fiona C Wardle, Adrienne M Flanagan

J Pathol. Author manuscript; available in PMC 2018 Aug 13.

Published in final edited form as: J Pathol. 2012 Nov; 228(3): 274–285. Published online 2012 Sep 26. doi: 10.1002/path.4082

PMCID:: PMC6089345

Abstract Article PDF–2.3M

Select item 563884613.

The driver landscape of sporadic chordoma

Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell

Nat Commun. 2017; 8: 890. Published online 2017 Oct 12. doi: 10.1038/s41467-017-01026-0

PMCID:: PMC5638846

Abstract Article PDF–938K

Select item 546436614.

Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival

Chetan Bettegowda, Stephen Yip, Sheng-Fu Larry Lo, Charles G. Fisher, Stefano Boriani, Laurence D. Rhines, Joanna Y. Wang, Aron Lazary, Marco Gambarotti, Wei-Lien Wang, Alessandro Luzzati, Mark B. Dekutoski, Mark H. Bilsky, Dean Chou, Michael G. Fehlings, Edward F. McCarthy, Nasir A. Quraishi, Jeremy J. Reynolds, Daniel M. Sciubba, Richard P. Williams, Jean-Paul Wolinsky, Patricia L. Zadnik, Ming Zhang, Niccole M. Germscheid, Vasiliki Kalampoki, Peter Pal Varga, Ziya L. Gokaslan, AOSpine Knowledge Forum Tumor

Neuro Oncol. 2017 Mar; 19(3): 405–413. Published online 2016 Sep 23. doi: 10.1093/neuonc/now156

PMCID:: PMC5464366

Abstract Article PDF–609K

Select item 534997615.

Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer

Yunping Hu, Xin Feng, Akiva Mintz, W. Jeffrey Petty, Wesley Hsu

Oncotarget. 2016 Dec 27; 7(52): 87124–87135. Published online 2016 Dec 24. doi: 10.18632/oncotarget.13547

PMCID:: PMC5349976

Abstract Article PDF–8.5M

Select item 504536416.

Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer

Filipe Pinto, Nelma Pértega-Gomes, José R. Vizcaíno, Raquel P. Andrade, Flavio M. Cárcano, Rui Manuel Reis

Oncotarget. 2016 May 17; 7(20): 28891–28902. Published online 2016 Mar 31. doi: 10.18632/oncotarget.8499

PMCID:: PMC5045364

Abstract Article PDF–4.9M

Select item 501009117.

Brachyury, a vaccine target, is overexpressed in triple negative breast cancer

Duane H. Hamilton, Mario Roselli, Patrizia Ferroni, Leopoldo Costarelli, Francesco Cavaliere, Mariateresa Taffuri, Claudia Palena, Fiorella Guadagni

Endocr Relat Cancer. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Endocr Relat Cancer. 2016 Oct; 23(10): 783–796. doi: 10.1530/ERC-16-0037

PMCID:: PMC5010091

Abstract Article PDF–3.8M

Select item 459300818.

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival

Yunping Hu, Akiva Mintz, Sagar R. Shah, Alfredo Quinones-Hinojosa, Wesley Hsu

Carcinogenesis. 2014 Jul; 35(7): 1491–1499. Published online 2014 Jan 20. doi: 10.1093/carcin/bgu014

PMCID:: PMC4593008

Abstract Article PDF–1.8M

Select item 456899019.

Overexpression of the EMT Driver Brachyury in Breast Carcinomas: Association With Poor Prognosis

Claudia Palena, Mario Roselli, Mary T. Litzinger, Patrizia Ferroni, Leopoldo Costarelli, Antonella Spila, Francesco Cavaliere, Bruce Huang, Romaine I. Fernando, Duane H. Hamilton, Caroline Jochems, Kwong-Yok Tsang, Qing Cheng, H. Kim Lyerly, Jeffrey Schlom, Fiorella Guadagni

J Natl Cancer Inst. 2014 May; 106(5): dju054. Published online 2014 May 9. doi: 10.1093/jnci/dju054

PMCID:: PMC4568990

Abstract Article PDF–810K

Select item 456794420.

NUCLEAR BRACHYURY EXPRESSION IS CONSISTENT IN CHORDOMA, COMMON IN GERM CELL TUMORS AND SMALL CELL CARCINOMAS AND RARE IN OTHER CARCINOMAS AND SARCOMAS. AN IMMUNOHISTOCHEMICAL STUDY OF 5229 CASES

Markku Miettinen, Zengfeng Wang, Jerzy Lasota, Christopher Heery, Jeffrey Schlom, Claudia Palena

Am J Surg Pathol. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Am J Surg Pathol. 2015 Oct; 39(10): 1305–1312. doi: 10.1097/PAS.0000000000000462

PMCID:: PMC4567944

Abstract Article PDF–3.9M

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