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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105438733.

KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis

Maria Hollmén, Atte Laaka, Juulia J. Partanen, Jukka Koskela, Eva Sutinen, Riitta Kaarteenaho, Mari Ainola, Marjukka Myllärniemi

Respir Res. 2023; 24: 240. Published online 2023 Sep 30. doi: 10.1186/s12931-023-02540-0

PMCID:: PMC10543873

Abstract Article PDF–1011K

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516155.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 99543346.

Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis

David Zhang, Gundula Povysil, Philippe H. Kobeissy, Qi Li, Binhan Wang, Mason Amelotte, Hager Jaouadi, Chad A. Newton, Toby M. Maher, Philip L. Molyneaux, Imre Noth, Fernando J. Martinez, Ganesh Raghu, Jamie L. Todd, Scott M. Palmer, Carolina Haefliger, Adam Platt, Slavé Petrovski, Joseph A. Garcia, David B. Goldstein, Christine Kim Garcia

Am J Respir Crit Care Med. 2022 Jul 1; 206(1): 56–69. Published online 2022 Apr 13. doi: 10.1164/rccm.202110-2439OC

PMCID:: PMC9954334

Abstract Article PDF–1.6M

Select item 99381897.

KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer

Gang Quan, Jian Xu, Jie Wang, Xinyuan Liu, Jichuan Xu, Jianxin Jiang

Cell Death Dis. 2023 Feb; 14(2): 137. Published online 2023 Feb 17. doi: 10.1038/s41419-023-05679-2

PMCID:: PMC9938189

Abstract Article PDF–8.4M

Select item 99224688.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 95926189.

Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer

Zhiwei He, Jie Wang, Jian Xu, Xueyi Jiang, Xinyuan Liu, Jianxin Jiang

Cell Death Dis. 2022 Oct; 13(10): 896. Published online 2022 Oct 25. doi: 10.1038/s41419-022-05338-y

PMCID:: PMC9592618

Abstract Article PDF–9.2M

Select item 951900310.

PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer

Hanpu Zhang, Chenyuan Li, Shichong Liao, Yi Tu, Shengrong Sun, Feng Yao, Zhiyu Li, Zhong Wang

Cancer Biol Ther. 2022; 23(1): 1–11. Published online 2022 Sep 22. doi: 10.1080/15384047.2022.2125260

PMCID:: PMC9519003

Abstract Article PDF–10M

Select item 927928511.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 876331712.

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation

Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley

Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h

PMCID:: PMC8763317

Abstract Article

Select item 874895813.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 869407414.

K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15

Marcus A. Begley, April L. Solon, Elizabeth Mae Davis, Michael Grant Sherrill, Ryoma Ohi, Mary Williard Elting

Mol Biol Cell. 2021 Dec 1; 32(22): br11. doi: 10.1091/mbc.E20-06-0426

PMCID:: PMC8694074

Abstract Article PDF–2.2M

Select item 836418115.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808827417.

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

Agnieszka T. Kawashima, Cassandra Wong, Gema Lordén, Charles C. King, Pablo Lara-Gonzalez, Arshad Desai, Anne-Claude Gingras, Alexandra C. Newton

Mol Cell Biol. 2021 Mar; 41(3): e00333-20. Prepublished online 2021 Jan 4. Published online 2021 Feb 23. doi: 10.1128/MCB.00333-20

PMCID:: PMC8088274

Abstract Article PDF–3.1M

Select item 778828618.

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

Paul van den Berk, Cesare Lancini, Carlos Company, Michela Serresi, Maria Pilar Sanchez-Bailon, Danielle Hulsman, Colin Pritchard, Ji-Ying Song, Matthias Jürgen Schmitt, Ellen Tanger, Oliver Popp, Philipp Mertins, Ivo J. Huijbers, Heinz Jacobs, Maarten van Lohuizen, Gaetano Gargiulo, Elisabetta Citterio

Cell Rep. 2020 Dec 29; 33(13): 108533. Published online 2020 Dec 29. doi: 10.1016/j.celrep.2020.108533

PMCID:: PMC7788286

Abstract Article

Select item 753297719.

B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer

Yanchao Ma, Shenghua Zhan, Huimin Lu, Ruoqin Wang, Yunyun Xu, Guangbo Zhang, Lei Cao, Tongguo Shi, Xueguang Zhang, Weichang Chen

Cell Death Dis. 2020 Oct; 11(10): 824. Published online 2020 Oct 3. doi: 10.1038/s41419-020-03041-4

PMCID:: PMC7532977

Abstract Article PDF–3.6M

Select item 729494720.

ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer

Huijuan Zeng, Tianfu Li, Duanyang Zhai, Jiong Bi, Xiaying Kuang, Sihong Lu, Zhen Shan, Ying Lin

Int J Biol Sci. 2020; 16(12): 2084–2093. Published online 2020 May 16. doi: 10.7150/ijbs.44204

PMCID:: PMC7294947

Abstract Article PDF–2.0M

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