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Select item 107669841.

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Tao Yuan, Chenming Zeng, Jiawei Liu, Chenxi Zhao, Fujing Ge, Yuekang Li, Meijia Qian, Jiamin Du, Weihua Wang, Yonghao Li, Yue Liu, Xiaoyang Dai, Jianya Zhou, Xueqin Chen, Shenglin Ma, Hong Zhu, Qiaojun He, Bo Yang

Signal Transduct Target Ther. 2024; 9: 11. Published online 2024 Jan 5. doi: 10.1038/s41392-023-01706-y

PMCID:: PMC10766984

Abstract Article PDF–7.0M

Select item 106300502.

去泛素化酶JOSD2通过调控DNA损伤修复影响非小细胞肺癌细胞对抗肿瘤药物的敏感性

葛孚晶, 刘湘宁, 张鸿宇, 袁涛, 朱虹, 杨波, 何俏军

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023 Oct 25; 52(5): 533–543. Chinese. Published online 2023 Oct 3. doi: 10.3724/zdxbyxb-2023-0256

PMCID:: PMC10630050

Abstract Article PDF–6.0M

Select item 94572483.

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer

Haibiao Xie, Jin Zhou, Xijuan Liu, Yawei Xu, Austin J. Hepperla, Jeremy M. Simon, Tao Wang, Hongwei Yao, Chengheng Liao, Albert S. Baldwin, Kan Gong, Qing Zhang

Proc Natl Acad Sci U S A. 2022 Sep 6; 119(36): e2119854119. Published online 2022 Aug 29. doi: 10.1073/pnas.2119854119

PMCID:: PMC9457248

Abstract Article PDF–3.1M

Select item 87278944.

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

Meijia Qian, Fangjie Yan, Weihua Wang, Jiamin Du, Tao Yuan, Ruilin Wu, Chenxi Zhao, Jiao Wang, Jiabin Lu, Bo Zhang, Nengming Lin, Xin Dong, Xiaoyang Dai, Xiaowu Dong, Bo Yang, Hong Zhu, Qiaojun He

Acta Pharm Sin B. 2021 Dec; 11(12): 4008–4019. Published online 2021 Jun 25. doi: 10.1016/j.apsb.2021.04.003

PMCID:: PMC8727894

Abstract Article PDF–3.2M

Select item 82050475.

High-throughput screening of functional deubiquitinating enzymes in autophagy

Shuo Tian, Shouheng Jin, Yaoxing Wu, Tao Liu, Man Luo, Jiayu Ou, Weihong Xie, Jun Cui

Autophagy. 2021; 17(6): 1367–1378. Published online 2020 May 26. doi: 10.1080/15548627.2020.1761652

PMCID:: PMC8205047

Abstract Article PDF–6.1M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79376857.

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism

Lyudmila Krassikova, Boxi Zhang, Divya Nagarajan, André Lima Queiroz, Merve Kacal, Evangelos Samakidis, Helin Vakifahmetoglu-Norberg, Erik Norberg

Cell Death Differ. 2021 Mar; 28(3): 1091–1109. Published online 2020 Oct 20. doi: 10.1038/s41418-020-00639-1

PMCID:: PMC7937685

Abstract Article PDF–4.9M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69433469.

USP37 is a SNAI1 deubiquitinase

Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma

Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.

PMCID:: PMC6943346

Abstract Article PDF–1.2M

Select item 631827310.

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

Tianzi Liuyu, Keying Yu, Liya Ye, Zhidong Zhang, Man Zhang, Yujie Ren, Zeng Cai, Qiyun Zhu, Dandan Lin, Bo Zhong

Cell Res. 2019 Jan; 29(1): 67–79. Published online 2018 Nov 8. doi: 10.1038/s41422-018-0107-6

PMCID:: PMC6318273

Abstract Article PDF–2.9M

Select item 617618311.

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin

Jongchan Kim, Fatemeh Alavi Naini, Yutong Sun, Li Ma

Am J Cancer Res. 2018; 8(9): 1823–1836. Published online 2018 Sep 1.

PMCID:: PMC6176183

Abstract Article PDF–3.1M

Select item 599587012.

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

Fan Yao, Zhicheng Zhou, Jongchan Kim, Qinglei Hang, Zhenna Xiao, Baochau N. Ton, Liang Chang, Na Liu, Liyong Zeng, Wenqi Wang, Yumeng Wang, Peijing Zhang, Xiaoyu Hu, Xiaohua Su, Han Liang, Yutong Sun, Li Ma

Nat Commun. 2018; 9: 2269. Published online 2018 Jun 11. doi: 10.1038/s41467-018-04620-y

PMCID:: PMC5995870

Abstract Article PDF–7.5M

Select item 589620213.

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

Dominika Kwasna, Syed Arif Abdul Rehman, Jayaprakash Natarajan, Stephen Matthews, Ross Madden, Virginia De Cesare, Simone Weidlich, Satpal Virdee, Ivan Ahel, Ian Gibbs-Seymour, Yogesh Kulathu

Mol Cell. 2018 Apr 5; 70(1): 150–164.e6. doi: 10.1016/j.molcel.2018.02.023

PMCID:: PMC5896202

Abstract Article

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522515.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 461721116.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043