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Select item 109680531.

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia

Ena Španić Popovački, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, Mirjana Babić Leko, Mihaela Pravica, Željka Krsnik, Darko Marčinko, Marina Šagud, Patrick R. Hof, Mihovil Mladinov, Goran Šimić

Biomolecules. 2024 Mar; 14(3): 302. Published online 2024 Mar 4. doi: 10.3390/biom14030302

PMCID:: PMC10968053

Abstract Article PDF–4.6M

Select item 107254832.

NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise

Kristian Barry, Christopher Murphy, Ashley Mansell

Commun Biol. 2023; 6: 1274. Published online 2023 Dec 16. doi: 10.1038/s42003-023-05684-3

PMCID:: PMC10725483

Abstract Article PDF–688K

Select item 105281933.

Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes

Lennice K. Castro, Matthew D. Daugherty

Curr Opin Immunol. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Curr Opin Immunol. 2023 Aug; 83: 102354. Published online 2023 Jun 11. doi: 10.1016/j.coi.2023.102354

PMCID:: PMC10528193

Abstract Article PDF–1004K

Select item 104716994.

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway

Yuanshui Wu, Xiaoli Huang, Le Yang, Yuanjie Liu

Sci Rep. 2023; 13: 14288. Published online 2023 Aug 31. doi: 10.1038/s41598-023-40748-8

PMCID:: PMC10471699

Abstract Article PDF–3.5M

Select item 101951805.

The Relationship between the Serum NLRP1 Level and Coronary Lesions in Patients with Coronary Artery Disease

Jing Zong, Yixiao Wang, Siyu Pan, Yiming Yang, Jingfeng Peng, Fangfang Li, Luhong Xu, Shanshan Li, Wenhao Qian

Int J Clin Pract. 2023; 2023: 2250055. Published online 2023 May 11. doi: 10.1155/2023/2250055

PMCID:: PMC10195180

Abstract Article PDF–291K

Select item 100422166.

Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

Elizabeth L. Orth-He, Hsin-Che Huang, Sahana D. Rao, Qinghui Wang, Qifeng Chen, Claire M. O’Mara, Ashley J. Chui, Michelle Saoi, Andrew R. Griswold, Abir Bhattacharjee, Daniel P. Ball, Justin R. Cross, Daniel A. Bachovchin

Cell Rep. Author manuscript; available in PMC 2023 Mar 27.

Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111965. Published online 2023 Jan 16. doi: 10.1016/j.celrep.2022.111965

PMCID:: PMC10042216

Abstract Article PDF–2.9M

Select item 99960117.

The NLRP1 inflammasome in skin diseases

Marc Burian, Morna F. Schmidt, Amir S. Yazdi

Front Immunol. 2023; 14: 1111611. Published online 2023 Feb 23. doi: 10.3389/fimmu.2023.1111611

PMCID:: PMC9996011

Abstract Article PDF–1005K

Select item 99421398.

The NLRP1 and CARD8 inflammasomes detect reductive stress

Qinghui Wang, Jeffrey C. Hsiao, Noah Yardeny, Hsin-Che Huang, Claire M. O’Mara, Elizabeth L. Orth-He, Daniel P. Ball, Ze Zhang, Daniel A. Bachovchin

Cell Rep. Author manuscript; available in PMC 2023 Feb 21.

Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111966. Published online 2023 Jan 16. doi: 10.1016/j.celrep.2022.111966

PMCID:: PMC9942139

Abstract Article PDF–3.4M

Select item 98005829.

High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells

Paulina Hennig, Michela Di Filippo, Gilles Bilfeld, Mark Mellett, Hans-Dietmar Beer

Cell Death Dis. 2022 Dec; 13(12): 1077. Published online 2022 Dec 29. doi: 10.1038/s41419-022-05530-0

PMCID:: PMC9800582

Abstract Article PDF–2.7M

Select item 970003710.

Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain

Jonas Moecking, Pawat Laohamonthonkul, Kubilay Meşe, Gregor Hagelueken, Annemarie Steiner, Cassandra R. Harapas, Jarrod J. Sandow, Jonathan D. Graves, Seth L. Masters, Matthias Geyer

J Biol Chem. 2022 Dec; 298(12): 102645. Published online 2022 Oct 26. doi: 10.1016/j.jbc.2022.102645

PMCID:: PMC9700037

Abstract Article PDF–2.7M

Select item 968476911.

A common variant close to the “tripwire” linker region of NLRP1 contributes to severe COVID-19

Vinicius N. C. Leal, Leandro M. Paulino, Raylane A. G. Cambui, Thiago G. Zupelli, Suemy M. Yamada, Leonardo A. T. Oliveira, Valéria de F. Dutra, Carolina B. Bub, Araci M. Sakashita, Ana Paula H. Yokoyama, José M. Kutner, Camila A. Vieira, Wellyngton M. de S. Santiago, Milena M. S. Andrade, Franciane M. E. Teixeira, Ricardo W. Alberca, Sarah C. Gozzi-Silva, Tatiana M. Yendo, Lucas C. Netto, Alberto J. S. Duarte, Maria N. Sato, James Venturini, Alessandra Pontillo

Inflamm Res. 2022 Nov 23 : 1–8. doi: 10.1007/s00011-022-01670-3 [Epub ahead of print]

PMCID:: PMC9684769

Abstract Article PDF–1.0M

Select item 962336812.

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D.J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kümmerer, Florian I. Schmidt

J Exp Med. 2023 Jan 2; 220(1): e20220837. Published online 2022 Oct 31. doi: 10.1084/jem.20220837

PMCID:: PMC9623368

Abstract Article PDF–8.2M

Select item 960343913.

NLRP1 in Cutaneous SCCs: An Example of the Complex Roles of Inflammasomes in Cancer Development

Michela Di Filippo, Paulina Hennig, Tugay Karakaya, Marta Slaufova, Hans-Dietmar Beer

Int J Mol Sci. 2022 Oct; 23(20): 12308. Published online 2022 Oct 14. doi: 10.3390/ijms232012308

PMCID:: PMC9603439

Abstract Article PDF–2.5M

Select item 910810014.

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Rémi Planès, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadão, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michèle Tiraby, COVID Human Genetic Effort, Qian Zhang, Pietro Cicuta, Emmanuelle Jouanguy, Olivier Neyrolles, Clare E. Bryant, Andres R. Floto, Caroline Goujon, Franklin Zhong Lei, Guillaume Martin-Blondel, Stein Silva, Jean-Laurent Casanova, Céline Cougoule, Bruno Reversade, Julien Marcoux, Emmanuel Ravet, Etienne Meunier

Mol Cell. 2022 Jul 7; 82(13): 2385–2400.e9. Published online 2022 May 16. doi: 10.1016/j.molcel.2022.04.033

PMCID:: PMC9108100

Abstract Article PDF–4.3M

Select item 889986315.

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

Andrew R. Griswold, Hsin-Che Huang, Daniel A. Bachovchin

Invest Ophthalmol Vis Sci. 2022 Mar; 63(3): 2. Published online 2022 Mar 3. doi: 10.1167/iovs.63.3.2

PMCID:: PMC8899863

Abstract Article PDF–1.9M

Select item 880755916.

The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis

Regina Sakalyte, Jaroslav Denkovskij, Eiva Bernotiene, Sigita Stropuviene, Silvija Ona Mikulenaite, Giedrius Kvederas, Narunas Porvaneckas, Vytautas Tutkus, Algirdas Venalis, Irena Butrimiene

Front Immunol. 2021; 12: 767512. Published online 2022 Jan 19. doi: 10.3389/fimmu.2021.767512

PMCID:: PMC8807559

Abstract Article PDF–2.3M

Select item 842743017.

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi

Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839

PMCID:: PMC8427430

Abstract Article PDF–2.1M

Select item 829953718.

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

L. Robert Hollingsworth, Humayun Sharif, Andrew R. Griswold, Pietro Fontana, Julian Mintseris, Kevin B. Dagbay, Joao A. Paulo, Steven P. Gygi, Daniel A. Bachovchin, Hao Wu

Nature. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 778–783. Published online 2021 Mar 17. doi: 10.1038/s41586-021-03350-4

PMCID:: PMC8299537

Article PDF–5.5M

Select item 826222319.

Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers

Seong Won Moon, Hyun Ji Son, Ha Yoon Mo, Nam Jin Yoo, Sug Hyung Lee

Pathol Oncol Res. 2021; 27: 607385. Published online 2021 Apr 16. doi: 10.3389/pore.2021.607385

PMCID:: PMC8262223

Abstract Article PDF–1.8M

Select item 816895520.

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J. White, Cassandra R. Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat-Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J. Calleja, Jay C. Horvat, Phil M. Hansbro, Robert J.J. O’Donoghue, Jenny P. Ting, Esteban G. Burchard, Matthias Geyer, Motti Gerlic, Seth L. Masters

J Allergy Clin Immunol. 2021 Jun; 147(6): 2134–2145.e20. doi: 10.1016/j.jaci.2020.12.636

PMCID:: PMC8168955

Abstract Article PDF–3.5M

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