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Select item 110023091.

Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression

Karina L. Bursch, Christopher J. Goetz, Guanming Jiao, Raymundo Nuñez, Michael D. Olp, Alisha Dhiman, Mallika Khurana, Michael T. Zimmermann, Raul A. Urrutia, Emily C. Dykhuizen, Brian C. Smith

J Biol Chem. 2024 Apr; 300(4): 107146. Published online 2024 Mar 7. doi: 10.1016/j.jbc.2024.107146

PMCID:: PMC11002309

Abstract Article PDF–2.5M

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 107948473.

Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

Patric J. Ho, Junghun Kweon, Laura A. Blumensaadt, Amy E. Neely, Elizabeth Kalika, Daniel B. Leon, Sanghyon Oh, Cooper W.P. Stringer, Sarah M. Lloyd, Ziyou Ren, Xiaomin Bao

Cell Genom. 2024 Jan 10; 4(1): 100471. Published online 2024 Jan 2. doi: 10.1016/j.xgen.2023.100471

PMCID:: PMC10794847

Abstract Article PDF–7.2M

Select item 105658764.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102048456.

Relationship between body composition and PBRM1 mutations in clear cell renal cell carcinoma: a propensity score matching analysis

Emin Demirel, Okan Dilek

Rev Assoc Med Bras (1992) 2023; 69(5): e20220415. Published online 2023 May 19. doi: 10.1590/1806-9282.20220415

PMCID:: PMC10204845

Abstract Article PDF–387K

Select item 101645647.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 101645528.

PBRM1 bromodomains associate with RNA to facilitate chromatin association

Saumya M De Silva, Alisha Dhiman, Surbhi Sood, Kilsia F Mercedes, William J Simmons, Morkos A Henen, Beat Vögeli, Emily C Dykhuizen, Catherine A Musselman

Nucleic Acids Res. 2023 May 8; 51(8): 3631–3649. Published online 2023 Feb 20. doi: 10.1093/nar/gkad072

PMCID:: PMC10164552

Abstract Article PDF–8.2M

Select item 99786359.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 997567510.

MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer

Nami Yamashita, Yoshihiro Morimoto, Atsushi Fushimi, Rehan Ahmad, Atrayee Bhattacharya, Tatsuaki Daimon, Naoki Haratake, Yuka Inoue, Satoshi Ishikawa, Masaaki Yamamoto, Tsuyoshi Hata, Sayuri Akiyoshi, Qiang Hu, Tao Liu, Henry Withers, Song Liu, Geoffrey I. Shapiro, Tomoharu Yoshizumi, Mark D. Long, Donald Kufe

Mol Cancer Res. 2023 Mar 1; 21(3): 274–289. Published online 2022 Nov 29. doi: 10.1158/1541-7786.MCR-22-0772

PMCID:: PMC9975675

Abstract Article PDF–12M

Select item 988113611.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 977255812.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969813.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 971565914.

Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB

Xia-ye Miao, Hao Wu, Bi-cheng Ye, Qian-wen Yi, Fang-nan Lin, Yi-lin Wang, Chuan-li Ren, Yan-fang Jiang, Ang Li

Sci Rep. 2022; 12: 20734. Published online 2022 Dec 1. doi: 10.1038/s41598-022-25050-3

PMCID:: PMC9715659

Abstract Article PDF–1.6M

Select item 954034515.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 952367816.

PBRM1 presents a potential prognostic marker and therapeutic target in duodenal papillary carcinoma

Xujun He, Ji Xu, Nan Niu, Guoxi Xu, Honglin Zhu, Zhengchuang Liu, Yiping Mou, Zhengyuan Qian, Huiju Wang, Junfeng Hu, Tonghui Ma, Jie Ma, Houquan Tao

Clin Transl Med. 2022 Oct; 12(10): e1062. Published online 2022 Sep 30. doi: 10.1002/ctm2.1062

PMCID:: PMC9523678

Abstract Article PDF–6.4M

Select item 951327117.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 935702618.

Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinoma

David A. Schoenfeld, Royce Zhou, Sakellarios Zairis, William Su, Nicole Steinbach, Deepti Mathur, Ankita Bansal, Alexis L. Zachem, Bertilia Tavarez, Dan Hasson, Emily Bernstein, Raul Rabadan, Ramon Parsons

Mol Cancer Res. Author manuscript; available in PMC 2023 Feb 5.

Published in final edited form as: Mol Cancer Res. 2022 Aug 5; 20(8): 1193–1207. doi: 10.1158/1541-7786.MCR-21-1039

PMCID:: PMC9357026

Abstract Article PDF–1.7M

Select item 934647119.

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation

Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung

EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468

PMCID:: PMC9346471

Abstract Article PDF–5.2M

Select item 934430820.

Clinicopathological Significance, Related Molecular Changes and Tumor Immune Response Analysis of the Abnormal SWI/SNF Complex Subunit PBRM1 in Gastric Adenocarcinoma

Zhiyi Zhou, Dandan Huang, Shudong Yang, Jiabei Liang, Xuan Wang, Qiu Rao

Pathol Oncol Res. 2022; 28: 1610479. Published online 2022 Jul 19. doi: 10.3389/pore.2022.1610479

PMCID:: PMC9344308

Abstract Article PDF–2.9M

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