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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 92560792.

MELK predicts poor prognosis and promotes metastasis in esophageal squamous cell carcinoma via activating the NF-κB pathway

Jiecheng Ye, Wanying Deng, Ying Zhong, Hui Liu, Baoyin Guo, Zixi Qin, Peiwen Li, Xueyun Zhong, Lihui Wang

Int J Oncol. 2022 Aug; 61(2): 94. Published online 2022 Jun 21. doi: 10.3892/ijo.2022.5384

PMCID:: PMC9256079

Abstract Article PDF–2.4M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74159914.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 65225035.

Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice

Hyun-A. Seong, Hyunjung Ha

Cell Death Dis. 2019 Jun; 10(6): 380. Published online 2019 May 16. doi: 10.1038/s41419-019-1616-z

PMCID:: PMC6522503

Abstract Article PDF–2.6M

Select item 64595106.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 59201107.

Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity

Hyun-A Seong, Ravi Manoharan, Hyunjung Ha

Cell Death Dis. 2018 May; 9(5): 471. Published online 2018 Apr 27. doi: 10.1038/s41419-018-0489-x

PMCID:: PMC5920110

Abstract Article PDF–2.6M

Select item 42702408.

Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β‐cell, regeneration

Cheng‐Ho Chung, Amber Miller, Andreas Panopoulos, Ergeng Hao, Robert Margolis, Alexey Terskikh, Fred Levine

Physiol Rep. 2014 Sep; 2(9): e12131. Published online 2014 Sep 4. doi: 10.14814/phy2.12131

PMCID:: PMC4270240

Abstract Article PDF–3.6M

Select item 41232959.

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms

Shuang Zhang, Shuangbo Kong, Bingyan Wang, Xiaohong Cheng, Yongjie Chen, Weiwei Wu, Qiang Wang, Junchao Shi, Ying Zhang, Shumin Wang, Jinhua Lu, John P Lydon, Francesco DeMayo, Warren S Pear, Hua Han, Haiyan Lin, Lei Li, Hongmei Wang, Yan-ling Wang, Bing Li, Qi Chen, Enkui Duan, Haibin Wang

Cell Res. 2014 Aug; 24(8): 925–942. Published online 2014 Jun 27. doi: 10.1038/cr.2014.82

PMCID:: PMC4123295

Abstract Article PDF–4.7M

Select item 411317910.

Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway

Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu, Bingya Liu

Mol Cancer. 2014; 13: 100. Published online 2014 May 4. doi: 10.1186/1476-4598-13-100

PMCID:: PMC4113179

Abstract Article PDF–2.3M

Select item 405938111.

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

Yubao Wang, Young-Mi Lee, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao

eLife. 2014; 3: e01763. Published online 2014 May 20. doi: 10.7554/eLife.01763

Correction in:: eLife. 2018; 7: e36414.

PMCID:: PMC4059381

Abstract Article PDF–4.0M

Select item 399026412.

MELK is Upregulated and Required in Mammary Tumor Initiating Cells In Vivo

Lionel Hebbard, Jochen Maurer, Amber Miller, Jacqueline Lesperance, John Hassell, Robert G. Oshima, Alexey Terskikh

Cancer Res. Author manuscript; available in PMC 2014 Apr 17.

Published in final edited form as: Cancer Res. 2010 Nov 1; 70(21): 8863–8873. Published online 2010 Sep 22. doi: 10.1158/0008-5472.CAN-10-1295

PMCID:: PMC3990264

Abstract Article PDF–1.7M

Select item 394020113.

The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity

Yong-Soon Cho, Jiho Yoo, Soomin Park, Hyun-Soo Cho

Acta Crystallogr D Biol Crystallogr. 2014 Feb 1; 70(Pt 2): 514–521. Published online 2014 Jan 31. doi: 10.1107/S1399004713027806

PMCID:: PMC3940201

Abstract Article PDF–1.2M

Select item 391664914.

Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks

Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte

Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464

PMCID:: PMC3916649

Abstract Article PDF–4.1M

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 337550516.

PDK1 Protein Phosphorylation at Thr³⁵⁴ by Murine Protein Serine-Threonine Kinase 38 Contributes to Negative Regulation of PDK1 Protein Activity

Hyun-A Seong, Haiyoung Jung, Ravi Manoharan, Hyunjung Ha

J Biol Chem. 2012 Jun 15; 287(25): 20811–20822. Published online 2012 Apr 27. doi: 10.1074/jbc.M111.331827

PMCID:: PMC3375505

Abstract Article PDF–2.3M

Select item 337550417.

Murine Protein Serine-threonine Kinase 38 Activates p53 Function through Ser¹⁵ Phosphorylation

Hyun-A Seong, Hyunjung Ha

J Biol Chem. 2012 Jun 15; 287(25): 20797–20810. Published online 2012 Apr 24. doi: 10.1074/jbc.M112.347757

PMCID:: PMC3375504

Abstract Article PDF–2.9M

Select item 325989418.

Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr⁸³⁸ Phosphorylation

Haiyoung Jung, Hyun-A Seong, Hyunjung Ha

J Biol Chem. 2008 Dec 12; 283(50): 34541–34553. doi: 10.1074/jbc.M807219200

PMCID:: PMC3259894

Abstract Article PDF–1.0M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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