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Items: 1 to 20 of 142

1.
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Jr, Xavier Graña
Nat Commun. 2024; 15: 5776. Published online 2024 Jul 10. doi: 10.1038/s41467-024-50015-7
PMCID:
PMC11233601
AbstractArticlePDF–11M
2.
To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling
Pegah Javadpour, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasemi
Cell Mol Life Sci. 2019 Jun; 76(12): 2277–2297. Published online 2019 Mar 14. doi: 10.1007/s00018-019-03063-y
PMCID:
PMC11105459
AbstractArticlePDF–1.5M
3.
The luciferase-based in vivo protein–protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction
Sana Ando, Keiko Tanaka, Maharu Matsumoto, Yuki Oyama, Yuri Tomabechi, Atsushi Yamagata, Mikako Shirouzu, Reiko Nakagawa, Noriaki Okimoto, Makoto Taiji, Koichi Sato, Takashi Ohama
J Biol Chem. 2024 May; 300(5): 107277. Published online 2024 Apr 6. doi: 10.1016/j.jbc.2024.107277
PMCID:
PMC11098961
AbstractArticlePDF–1.2M
4.
Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes
Franziska Wachter, Radosław P. Nowak, Scott Ficarro, Jarrod Marto, Eric S. Fischer
J Biol Chem. 2024 May; 300(5): 107268. Published online 2024 Apr 4. doi: 10.1016/j.jbc.2024.107268
PMCID:
PMC11087950
AbstractArticlePDF–2.5M
5.
PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation
Chitra Palanivel, Lepakshe S. V. Madduri, Ashley L. Hein, Christopher B. Jenkins, Brendan T. Graff, Alison L. Camero, Sumin Zhou, Charles A. Enke, Michel M. Ouellette, Ying Yan
Aging (Albany NY) 2024 Mar 15; 16(5): 4116–4137. Published online 2024 Mar 4. doi: 10.18632/aging.205619
PMCID:
PMC10968692
AbstractArticlePDF–2.4M
6.
PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells
Naoki Kohyanagi, Nao Kitamura, Shunta Ikeda, Shusaku Shibutani, Koichi Sato, Takashi Ohama
J Biol Chem. 2024 Jan; 300(1): 105584. Published online 2023 Dec 22. doi: 10.1016/j.jbc.2023.105584
PMCID:
PMC10826185
AbstractArticlePDF–1.8M
7.
PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation
Jian Wang, Yuke Chen, Shiwei Li, Wanchang Liu, Xiao Albert Zhou, Yefei Luo, Zhanzhan Xu, Yundong Xiong, Kaiqi Cheng, Mingjian Ruan, Wei Yu, Xiaoman Li, Weibin Wang, Jiadong Wang
J Clin Invest. 2024 Jan 2; 134(1): e172137. Published online 2024 Jan 2. doi: 10.1172/JCI172137
PMCID:
PMC10760972
AbstractArticlePDF–15M
8.
Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance
Reyaz ur Rasool, Caitlin M. O’Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E. Frohner, Qu Deng, Erick Mitchell-Velasquez, Jaya Sangodkar, Aqila Ahmed, Sarah Linauer, Ingrid Mudrak, Jessica Rainey, Kaitlin P. Zawacki, Tahra K. Suhan, Catherine G. Callahan, Ryan Rebernick, Ramakrishnan Natesan, Javed Siddiqui, Guido Sauter, Dafydd Thomas, Shaomeng Wang, Derek J. Taylor, Ronald Simon, Marcin Cieslik, Arul M. Chinnaiyan, Luca Busino, Egon Ogris, Goutham Narla, Irfan A. Asangani
Nat Commun. 2023; 14: 5253. Published online 2023 Aug 29. doi: 10.1038/s41467-023-40760-6
PMCID:
PMC10465527
AbstractArticlePDF–4.1M
9.
Protein phosphatase 2A propels follicular T helper cell development in lupus
Yu Jiang, Xuexiao Jin, Zhexu Chi, Yadan Bai, Kalpana Manthiram, Pamela Mudd, Kaixiang Zhu, Lie Wang, Pamela L. Schwartzberg, Yongmei Han, Xiang Gao, Linrong Lu, Qin Xu
J Autoimmun. Author manuscript; available in PMC 2024 Apr 1.
Published in final edited form as: J Autoimmun. 2023 Apr; 136: 103028. Published online 2023 Mar 29. doi: 10.1016/j.jaut.2023.103028
PMCID:
PMC10327577
AbstractArticlePDF–2.6M
10.
PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis
Kallesh D. Jayappa, Brian Tran, Vicki L. Gordon, Christopher Morris, Shekhar Saha, Caroline C. Farrington, Caitlin M. O’Connor, Kaitlin P. Zawacki, Krista M. Isaac, Mark Kester, Timothy P. Bender, Michael E. Williams, Craig A. Portell, Michael J. Weber, Goutham Narla
J Clin Invest. 2023 Jul 3; 133(13): e155938. Published online 2023 Jul 3. doi: 10.1172/JCI155938
PMCID:
PMC10313372
AbstractArticlePDF–4.2M
11.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
12.
PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability
Christina Fevga, Christelle Tesson, Ana Carreras Mascaro, Thomas Courtin, Riaan van Coller, Salma Sakka, Federico Ferraro, Nouha Farhat, Soraya Bardien, Mariem Damak, Jonathan Carr, Mélanie Ferrien, Valerie Boumeester, Jasmijn Hundscheid, Nicola Grillenzoni, Irini A Kessissoglou, Demy J S Kuipers, Marialuisa Quadri, French and Mediterranean Parkinson disease Genetics Study Group , International Parkinsonism Genetics Network , Jean-Christophe Corvol, Chokri Mhiri, Bassem A Hassan, Guido J Breedveld, Suzanne Lesage, Wim Mandemakers, Alexis Brice, Vincenzo Bonifati
Brain. 2023 Apr; 146(4): 1496–1510. Published online 2022 Sep 8. doi: 10.1093/brain/awac326
PMCID:
PMC10115167
AbstractArticlePDF–1.7M
13.
Hsa‐miR‐409‐3p regulates endothelial progenitor senescence via PP2A‐P38 and is a potential ageing marker in humans
Yi‐Nan Lee, Yih‐Jer Wu, Hsin‐I Lee, Hsueh‐Hsiao Wang, Chung‐Lieh Hung, Chiung‐Yin Chang, Yen‐Hung Chou, Ting‐Yi Tien, Chun‐Wei Lee, Chao‐Feng Lin, Cheng‐Huang Su, Hung‐I Yeh
J Cell Mol Med. 2023 Mar; 27(5): 687–700. Published online 2023 Feb 9. doi: 10.1111/jcmm.17691
PMCID:
PMC9983318
AbstractArticlePDF–3.8M
14.
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Nat Commun. 2023; 14: 1143. Published online 2023 Feb 28. doi: 10.1038/s41467-023-36693-9
PMCID:
PMC9974998
AbstractArticlePDF–2.7M
15.
ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II
Seina Ohe, Yuji Kubota, Kiyoshi Yamaguchi, Yusuke Takagi, Junichiro Nashimoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoichi Furukawa, Mutsuhiro Takekawa
Nat Commun. 2022; 13: 7476. Published online 2022 Dec 3. doi: 10.1038/s41467-022-35230-4
PMCID:
PMC9719515
AbstractArticlePDF–3.5M
16.
A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility
Marta Ripamonti, Andrea Lamarca, Norman E. Davey, Diletta Tonoli, Sara Surini, Ivan de Curtis
Commun Biol. 2022; 5: 1025. Published online 2022 Sep 28. doi: 10.1038/s42003-022-03989-3
PMCID:
PMC9519923
AbstractArticlePDF–5.8M
17.
A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation
Jean-Marie Sontag, Diana Schuhmacher, Goce Taleski, Anthony Jordan, Sarah Khan, Alexander Hoffman, Rey J. Gomez, Matthew D. Mazalouskas, Steven K. Hanks, Benjamin W. Spiller, Estelle Sontag, Brian E. Wadzinski
J Biol Chem. 2022 Aug; 298(8): 102248. Published online 2022 Jul 9. doi: 10.1016/j.jbc.2022.102248
PMCID:
PMC9396060
AbstractArticlePDF–2.7M
18.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
19.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
20.
HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk
Qiujin Yan, Xiulin Wu, Ping Zhou, Yan Zhou, Xuhang Li, Zhongchun Liu, Huawei Tan, Wei Yao, Yaru Xia, Fan Zhu
Viruses. 2022 Jan; 14(1): 145. Published online 2022 Jan 14. doi: 10.3390/v14010145
PMCID:
PMC8777930
AbstractArticlePDF–31M

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