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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110443262.

Identification of a novel GNAS mutation in a family with pseudohypoparathyroidism type 1A

Fabio Sippelli, Silvana Briuglia, Chiara Ferraloro, Anna Paola Capra, Emanuele Agolini, Tiziana Abbate, Giorgia Pepe, Tommaso Aversa, Malgorzata Wasniewska, Domenico Corica

BMC Pediatr. 2024; 24: 271. Published online 2024 Apr 25. doi: 10.1186/s12887-024-04761-8

PMCID:: PMC11044326

Abstract Article PDF–981K

Select item 110059403.

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M. Rosenbaum, Jin-Peng Sun, Yang Du, Lei Zhang, Xiao Yu, Zhenhua Shao

Cell. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Cell. 2021 Feb 18; 184(4): 943–956.e18. Published online 2021 Feb 10. doi: 10.1016/j.cell.2021.01.028

PMCID:: PMC11005940

Abstract Article PDF–1.8M

Select item 109725834.

GNAS AS2 methylation status enables mechanism-based categorization of pseudohypoparathyroidism type 1B

Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

JCI Insight. 2024 Mar 8; 9(5): e177190. Published online 2024 Jan 30. doi: 10.1172/jci.insight.177190

PMCID:: PMC10972583

Abstract Article PDF–4.0M

Select item 109457075.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109424676.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 109168667.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 108308478.

DNA methylation landscape reveals GNAS as a decitabine-responsive marker in patients with acute myeloid leukemia

Shujiao He, Yan Li, Lei Wang, Yisheng Li, Lu Xu, Diya Cai, Jingfeng Zhou, Li Yu

Neoplasia. 2024 Mar; 49: 100965. Published online 2024 Jan 20. doi: 10.1016/j.neo.2024.100965

PMCID:: PMC10830847

Abstract Article PDF–4.2M

Select item 108037319.

Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma

C. Simon Herrington, Ailsa J. Oswald, Lorna J. Stillie, Ian Croy, Michael Churchman, Robert L. Hollis

Br J Cancer. 2024 Feb 10; 130(2): 327–335. Published online 2023 Dec 14. doi: 10.1038/s41416-023-02508-3

PMCID:: PMC10803731

Abstract Article PDF–2.4M

Select item 1076495810.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1061767311.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1030885612.

Preferential Maternal Transmission of STX16-GNAS Mutations Responsible for Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B): Another Example of Transmission Ratio Distortion

Zentaro Kiuchi, Monica Reyes, Harald Jüppner

J Bone Miner Res. Author manuscript; available in PMC 2023 Jun 29.

Published in final edited form as: J Bone Miner Res. 2021 Apr; 36(4): 696–703. Published online 2020 Dec 27. doi: 10.1002/jbmr.4221

PMCID:: PMC10308856

Abstract Article PDF–1001K

Select item 1023742213.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017878614.

Whole‐genome sequencing revealed a novel long‐range deletion mutation spanning GNAS in familial pseudohypoparathyroidism

Yangfan Fei, Lv Liu, Lixia Wu, Ou Wang, Xiaoping Xing, Aiping Li, Lingyi Huang

Mol Genet Genomic Med. 2023 May; 11(5): e2144. Published online 2023 Jan 20. doi: 10.1002/mgg3.2144

PMCID:: PMC10178786

Abstract Article PDF–2.6M

Select item 1013184215.

GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer

Junwei Tang, Wen Peng, Jiangzhou Ji, Chaofan Peng, Tuo Wang, Peng Yang, Ji'ou Gu, Yifei Feng, Kangpeng Jin, Xiaowei Wang, Yueming Sun

Adv Sci (Weinh) 2023 Apr; 10(12): 2205627. Published online 2023 Mar 11. doi: 10.1002/advs.202205627

PMCID:: PMC10131842

Abstract Article PDF–5.8M

Select item 1010490216.

The long-range interaction between two GNAS imprinting control regions delineates pseudohypoparathyroidism type 1B pathogenesis

Yorihiro Iwasaki, Cagri Aksu, Monica Reyes, Birol Ay, Qing He, Murat Bastepe

J Clin Invest. 2023 Apr 17; 133(8): e167953. Published online 2023 Apr 17. doi: 10.1172/JCI167953

PMCID:: PMC10104902

Abstract Article PDF–4.5M

Select item 998681717.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 995044718.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 982313119.

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth

David J. Wisniewski, Mariya S. Liyasova, Soumya Korrapati, Xu Zhang, Shashikala Ratnayake, Qingrong Chen, Samuel F. Gilbert, Alexis Catalano, Donna Voeller, Daoud Meerzaman, Udayan Guha, Natalie Porat-Shliom, Christina M. Annunziata, Stanley Lipkowitz

J Biol Chem. 2023 Jan; 299(1): 102766. Published online 2022 Dec 5. doi: 10.1016/j.jbc.2022.102766

PMCID:: PMC9823131

Abstract Article PDF–2.5M

Select item 979798820.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

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