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Select item 109464371.

Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification

Andy Yang, Rony Chidiac, Emma Russo, Hendrik Steenland, Quinn Pauli, Robert Bonin, Levi L. Blazer, Jarrett J. Adams, Sachdev S. Sidhu, Aleksandrina Goeva, Ali Salahpour, Stephane Angers

Development. 2024 Mar 1; 151(5): dev202545. Published online 2024 Mar 4. doi: 10.1242/dev.202545

PMCID:: PMC10946437

Abstract Article

Select item 101240062.

A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA

Pei Lu, Jie Yang, Mao Li, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang

Genome Biol. 2023; 24: 92. Published online 2023 Apr 24. doi: 10.1186/s13059-023-02925-w

PMCID:: PMC10124006

Abstract Article PDF–5.9M

Select item 99887033.

Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV)

Yuanyuan Chen, Cheng Wu, Shanzhen Peng, Dianlei Guo, Hong Ouyang, Yanhong Wei, Rong Ju, Xiaoyan Ding, Zhi Xie, Chunqiao Liu

Invest Ophthalmol Vis Sci. 2023 Mar; 64(3): 8. Published online 2023 Mar 3. doi: 10.1167/iovs.64.3.8

PMCID:: PMC9988703

Abstract Article PDF–13M

Select item 95349574.

Aberrant Cholesterol Metabolism and Wnt/β‐Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth

Shaoqin Zheng, Jiahui Lin, Zhongqiu Pang, Hui Zhang, Yinuo Wang, Lanjing Ma, Haijiao Zhang, Xi Zhang, Maorong Chen, Xinjun Zhang, Chao Zhao, Jun Qi, Liu Cao, Min Wang, Xi He, Ren Sheng

Adv Sci (Weinh) 2022 Oct; 9(28): 2200750. Published online 2022 Aug 17. doi: 10.1002/advs.202200750

PMCID:: PMC9534957

Abstract Article PDF–6.1M

Select item 90548485.

RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface

A-Ri Cho, Hee Jung Sul, Yoo Jin Kim, Bohyun Kim, Dae Young Zang

Sci Rep. 2022; 12: 7013. Published online 2022 Apr 29. doi: 10.1038/s41598-022-10868-8

PMCID:: PMC9054848

Abstract Article PDF–1.6M

Select item 84646046.

Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload

Yan Zou, Le Pan, Yi Shen, Xiang Wang, Chenxing Huang, Hao Wang, Xuejuan Jin, Chao Yin, Ying Wang, Jianguo Jia, Juying Qian, Yunzeng Zou, Hui Gong, Junbo Ge

Cell Death Dis. 2021 Oct; 12(10): 877. Published online 2021 Sep 25. doi: 10.1038/s41419-021-04152-2

PMCID:: PMC8464604

Abstract Article PDF–9.6M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79860968.

FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells

Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, Hideyuki Okano, Yumi Matsuzaki

Stem Cells. 2021 Mar; 39(3): 318–330. Published online 2020 Dec 22. doi: 10.1002/stem.3317

PMCID:: PMC7986096

Abstract Article PDF–11M

Select item 78987459.

FZD5 prevents epithelial-mesenchymal transition in gastric cancer

Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang

Cell Commun Signal. 2021; 19: 21. Published online 2021 Feb 22. doi: 10.1186/s12964-021-00708-z

PMCID:: PMC7898745

Abstract Article PDF–7.2M

Select item 788393110.

Confirming and expanding the phenotypes of FZD5 variants: Coloboma, inferior chorioretinal hypoplasia, and high myopia

Yi Jiang, Jiamin Ouyang, Shiqiang Li, Xueshan Xiao, Wenmin Sun, Qingjiong Zhang

Mol Vis. 2021; 27: 50–60. Published online 2021 Jan 20.

PMCID:: PMC7883931

Abstract Article PDF–10M

Select item 785307411.

Confirmation of FZD5 implication in a cohort of 50 patients with ocular coloboma

Marion Aubert-Mucca, Julie Pernin-Grandjean, Sébastien Marchasson, Veronique Gaston, Christophe Habib, Isabelle Meunier, Sabine Sigaudy, Josseline Kaplan, Olivier Roche, Danièle Denis, Pierre Bitoun, Damien Haye, Alain Verloes, Patrick Calvas, Nicolas Chassaing, Julie Plaisancié

Eur J Hum Genet. 2021 Jan; 29(1): 131–140. Published online 2020 Jul 31. doi: 10.1038/s41431-020-0695-8

PMCID:: PMC7853074

Abstract Article PDF–659K

Select item 773359912.

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness

Yu Sun, Zhuo Wang, Lei Na, Dan Dong, Wei Wang, Chenghai Zhao

Cell Death Dis. 2020 Dec; 11(12): 1060. Published online 2020 Dec 12. doi: 10.1038/s41419-020-03282-3

PMCID:: PMC7733599

Abstract Article PDF–3.2M

Select item 752192313.

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis

Maorong Chen, Nathalia Amado, Jieqiong Tan, Alice Reis, Mengxu Ge, Jose Garcia Abreu, Xi He

eLife. 2020; 9: e56793. Published online 2020 Sep 14. doi: 10.7554/eLife.56793

PMCID:: PMC7521923

Abstract Article PDF–7.4M

Select item 744248914.

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia

eLife. 2020; 9: e58464. Published online 2020 Aug 7. doi: 10.7554/eLife.58464

PMCID:: PMC7442489

Abstract Article PDF–4.9M

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 653064416.

Upregulation of FZD5 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Epigenetic Modification

Jong-Yeup Kim, Min-Ji Cha, Young-Seon Park, Jaeku Kang, Jong-Joong Choi, Seung Min In, Dong-Kyu Kim

Mol Cells. 2019 Apr; 42(4): 345–355. Published online 2019 Apr 2. doi: 10.14348/molcells.2019.2418

PMCID:: PMC6530644

Abstract Article PDF–3.6M

Select item 631412517.

Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

Yue Hua, Yilin Yang, Qian Li, Xinyu He, Wei Zhu, Jiyong Wang, Xiaoqing Gan

J Biol Chem. 2018 Dec 21; 293(51): 19710–19724. Published online 2018 Oct 25. doi: 10.1074/jbc.RA118.004434

PMCID:: PMC6314125

Abstract Article PDF–4.2M

Select item 623149918.

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B

Peng Chen, Liang Tao, Tianyu Wang, Jie Zhang, Aina He, Kwok-ho Lam, Zheng Liu, Xi He, Kay Perry, Min Dong, Rongsheng Jin

Science. Author manuscript; available in PMC 2019 May 11.

Published in final edited form as: Science. 2018 May 11; 360(6389): 664–669. doi: 10.1126/science.aar1999

PMCID:: PMC6231499

Abstract Article PDF–2.3M

Select item 620889819.

Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1

Maarten M. Brandt, Christian G. M. van Dijk, Ihsan Chrifi, Heleen M. Kool, Petra E. Bürgisser, Laura Louzao-Martinez, Jiayi Pei, Robbert J. Rottier, Marianne C. Verhaar, Dirk J. Duncker, Caroline Cheng

Angiogenesis. 2018; 21(4): 805–821. Published online 2018 May 29. doi: 10.1007/s10456-018-9625-6

PMCID:: PMC6208898

Abstract Article PDF–14M

Select item 582692620.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

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