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Items: 1 to 20 of 55

1.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
2.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
3.
Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation
Huige Lin, Lin Wang, Zhuohao Liu, Kekao Long, Mengjie Kong, Dewei Ye, Xi Chen, Kai Wang, Kelvin KL Wu, Mengqi Fan, Erfei Song, Cunchuan Wang, Ruby LC Hoo, Xiaoyan Hui, Philip Hallenborg, Hailong Piao, Aimin Xu, Kenneth KY Cheng
Adv Sci (Weinh) 2022 Jul; 9(20): 2200742. Published online 2022 May 7. doi: 10.1002/advs.202200742
PMCID:
PMC9284139
AbstractArticlePDF–6.3M
4.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
5.
MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury
Qiang Wang, Ki Ho Park, Bingchuan Geng, Peng Chen, Chunlin Yang, Qiwei Jiang, Frank Yi, Tao Tan, Xinyu Zhou, Zehua Bian, Jianjie Ma, Hua Zhu
Front Cardiovasc Med. 2022; 9: 868632. Published online 2022 May 31. doi: 10.3389/fcvm.2022.868632
PMCID:
PMC9193967
AbstractArticlePDF–1.6M
6.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
7.
The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins
Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo
BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y
PMCID:
PMC8744257
AbstractArticlePDF–6.0M
8.
A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein
Nikki M. McCormack, Mahlet B. Abera, Eveline S. Arnold, Rebecca M. Gibbs, Scott E. Martin, Eugen Buehler, Yu-Chi Chen, Lu Chen, Kenneth H. Fischbeck, Barrington G. Burnett
Cell Rep. Author manuscript; available in PMC 2021 Dec 17.
Published in final edited form as: Cell Rep. 2021 May 11; 35(6): 109125. doi: 10.1016/j.celrep.2021.109125
PMCID:
PMC8679797
AbstractArticlePDF–2.1M
9.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis
Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang
Autophagy. 2021; 17(10): 3030–3047. Published online 2020 Dec 17. doi: 10.1080/15548627.2020.1851496
PMCID:
PMC8525924
AbstractArticlePDF–18M
10.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
11.
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
Dawafuti Sherpa, Jakub Chrustowicz, Shuai Qiao, Christine R. Langlois, Laura A. Hehl, Karthik Varma Gottemukkala, Fynn M. Hansen, Ozge Karayel, Susanne von Gronau, J. Rajan Prabu, Matthias Mann, Arno F. Alpi, Brenda A. Schulman
Mol Cell. 2021 Jun 3; 81(11): 2445–2459.e13. doi: 10.1016/j.molcel.2021.03.025
PMCID:
PMC8189437
AbstractArticle
12.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
13.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
14.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
15.
Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer’s Disease
Key-Hwan Lim, Jae-Yeol Joo
Int J Mol Sci. 2020 May; 21(9): 3398. Published online 2020 May 11. doi: 10.3390/ijms21093398
PMCID:
PMC7246987
AbstractArticlePDF–4.7M
16.
MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment
Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D. Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav
Cell Rep. Author manuscript; available in PMC 2020 Mar 3.
Published in final edited form as: Cell Rep. 2019 Feb 12; 26(7): 1800–1814.e5. doi: 10.1016/j.celrep.2019.01.075
PMCID:
PMC7053169
AbstractArticlePDF–2.3M
17.
PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ
Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz
iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026
PMCID:
PMC6424098
AbstractArticlePDF–11M
18.
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers, Manfred Auer
BMC Biol. 2018; 16: 88. Published online 2018 Aug 10. doi: 10.1186/s12915-018-0554-z
PMCID:
PMC6086040
AbstractArticlePDF–1.4M
19.
The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation
Fabienne Lampert, Diana Stafa, Algera Goga, Martin Varis Soste, Samuel Gilberto, Natacha Olieric, Paola Picotti, Markus Stoffel, Matthias Peter
eLife. 2018; 7: e35528. Published online 2018 Jun 18. doi: 10.7554/eLife.35528
PMCID:
PMC6037477
AbstractArticlePDF–1.5M
20.
A role for mitochondrial translation in promotion of viability in K-Ras mutant cells
Timothy D. Martin, Danielle R. Cook, Mei Yuk Choi, Mamie Z. Li, Kevin M. Haigis, Stephen J. Elledge
Cell Rep. Author manuscript; available in PMC 2017 Aug 11.
Published in final edited form as: Cell Rep. 2017 Jul 11; 20(2): 427–438. doi: 10.1016/j.celrep.2017.06.061
PMCID:
PMC5553568
AbstractArticlePDF–1.8M

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