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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 93572182.

Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML

Alison E. Meyer, Cary Stelloh, Kirthi Pulakanti, Robert Burns, Joseph B. Fisher, Katelyn E. Heimbruch, Sergey Tarima, Quinlan Furumo, John Brennan, Yongwei Zheng, Aaron D. Viny, George S. Vassiliou, Sridhar Rao

Leukemia. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Leukemia. 2022 Aug; 36(8): 2032–2041. Published online 2022 Jul 1. doi: 10.1038/s41375-022-01632-y

PMCID:: PMC9357218

Abstract Article PDF–1.8M

Select item 91262643.

Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development

Jian Zhang, Xiangkai Zhao, Yunyun Guo, Zhiping Liu, Shujian Wei, Qiuhuan Yuan, Haixia Shang, Wentao Sang, Sumei Cui, Tonghui Xu, Kehui Yang, Jialin Guo, Chang Pan, Jiali Wang, Jiaojiao Pang, Tianrui Han, Yuguo Chen, Feng Xu

Arterioscler Thromb Vasc Biol. 2022 Jun; 42(6): 700–716. Published online 2022 Mar 31. doi: 10.1161/ATVBAHA.121.317204

Correction in:: Arterioscler Thromb Vasc Biol. 2022 Aug; 42(8): e252.

PMCID:: PMC9126264

Abstract Article PDF–4.5M

Select item 88854214.

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia

Shailaja Hegde, Anjelika Gasilina, Mark Wunderlich, Yuan Lin, Marcel Buchholzer, Oliver H. F. Krumbach, Mohammad Akbarzadeh, Mohammad Reza Ahmadian, William Seibel, Yi Zheng, John P. Perentesis, Benjamin E. Mizukawa, Lisa Privette Vinnedge, José A. Cancelas, Nicolas N. Nassar

Leukemia. 2022; 36(3): 637–647. Published online 2021 Oct 28. doi: 10.1038/s41375-021-01455-3

PMCID:: PMC8885421

Abstract Article PDF–3.3M

Select item 78877585.

Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector T_reg cells

Wei Su, Nicole M. Chapman, Jun Wei, Hu Zeng, Yogesh Dhungana, Hao Shi, Jordy Saravia, Peipei Zhou, Lingyun Long, Sherri Rankin, KC Anil, Peter Vogel, Hongbo Chi

Cell Metab. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Cell Metab. 2020 Dec 1; 32(6): 996–1011.e7. Published online 2020 Nov 17. doi: 10.1016/j.cmet.2020.10.022

PMCID:: PMC7887758

Abstract Article PDF–2.6M

Select item 76112026.

HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases

Melanie Kogler, Luigi Tortola, Gian Luca Negri, Alexandra Leopoldi, Amal M. El-Naggar, Stefan Mereiter, Carlos Gomez Diaz, Roberto Nitsch, Davide Tortora, Anoop M. Kavirayani, Bianca V. Gapp, Shuan Rao, Iris Uribesalgo, David Hoffmann, Domagoj Cikes, Maria Novatchkova, David A. Williams, Jeffrey M. Trent, Fumiyo Ikeda, Mads Daugaard, Astrid Hagelkruys, Poul H. Sorensen, Josef M. Penninger

Cancer Res. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Cancer Res. 2020 Jul 15; 80(14): 3009–3022. Published online 2020 May 4. doi: 10.1158/0008-5472.CAN-19-2270

PMCID:: PMC7611202

Abstract Article PDF–3.5M

Select item 71847557.

Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation

In Soon Kang, Jin Sun Jang, Chaekyun Kim

Sci Rep. 2020; 10: 7024. Published online 2020 Apr 27. doi: 10.1038/s41598-020-63673-6

PMCID:: PMC7184755

Abstract Article PDF–3.5M

Select item 71168368.

Escherichia coli RhoGTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21 activated kinases-1/2 during bacteremia in mice

Océane Dufies, Anne Doye, Johan Courjon, Cédric Torre, Gregory Michel, Celine Loubatier, Arnaud Jacquel, Paul Chaintreuil, Alissa Majoor, Rodolphe R. Guinamard, Alexandre Gallerand, Pedro H. V. Saavedra, Els Verhoeyen, Amaury Rey, Sandrine Marchetti, Raymond Ruimy, Dorota Czerucka, Mohamed Lamkanfi, Bénédicte F. Py, Patrick Munro, Orane Visvikis, Laurent Boyer

Nat Microbiol. Author manuscript; available in PMC 2021 Jul 11.

Published in final edited form as: Nat Microbiol. 2021 Mar 1; 6(3): 401–412. Published online 2021 Jan 11. doi: 10.1038/s41564-020-00832-5

PMCID:: PMC7116836

Abstract Article PDF–4.1M

Select item 70124749.

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome

Tianxiang Hu, Yating Chong, Sumin Lu, Meaghan McGuinness, David A. Williams, John K. Cowell

Haematologica. 2020 Feb; 105(2): e68–e71. doi: 10.3324/haematol.2018.208058

PMCID:: PMC7012474

Article PDF–1.1M

Select item 649751610.

Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects

Amy P. Hsu, Agnes Donkó, Megan E. Arrington, Muthulekha Swamydas, Danielle Fink, Arundhoti Das, Omar Escobedo, Vincent Bonagura, Paul Szabolcs, Harry N. Steinberg, Jenna Bergerson, Amanda Skoskiewicz, Melanie Makhija, Joie Davis, Ladan Foruraghi, Cindy Palmer, Ramsay L. Fuleihan, Joseph A. Church, Avinash Bhandoola, Michail S. Lionakis, Sharon Campbell, Thomas L. Leto, Douglas B. Kuhns, Steven M. Holland

Blood. 2019 May 2; 133(18): 1977–1988. Prepublished online 2019 Feb 5. doi: 10.1182/blood-2018-11-886028

PMCID:: PMC6497516

Abstract Article

Select item 581825111.

Crk proteins transduce FGF signaling to promote lens fiber cell elongation

Tamica N Collins, Yingyu Mao, Hongge Li, Michael Bouaziz, Angela Hong, Gen-Sheng Feng, Fen Wang, Lawrence A Quilliam, Lin Chen, Taeju Park, Tom Curran, Xin Zhang

eLife. 2018; 7: e32586. Published online 2018 Jan 23. doi: 10.7554/eLife.32586

PMCID:: PMC5818251

Abstract Article PDF–8.2M

Select item 556053712.

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Shweta Joshi, Alok R. Singh, Simon S. Wong, Muamera Zulcic, Min Jiang, Annie Pardo, Moises Selman, James S. Hagood, Donald L. Durden

PLoS One. 2017; 12(8): e0182851. Published online 2017 Aug 17. doi: 10.1371/journal.pone.0182851

PMCID:: PMC5560537

Abstract Article PDF–6.6M

Select item 538122613.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 526951014.

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage IL-1β Production

Nicolle Ceneri, Lina Zhao, Bryan D. Young, Abigail Healy, Suleyman Coskun, Hema Vasavada, Timur O. Yarovinsky, Kenneth Ike, Ruggero Pardi, Lingfen Qin, Li Qin, George Tellides, Karen Hirschi, Judith Meadows, Robert Soufer, Hyung J. Chun, Mehran M. Sadeghi, Jeffrey R. Bender, Alan R. Morrison

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 Feb; 37(2): 328–340. Published online 2016 Nov 10. doi: 10.1161/ATVBAHA.116.308507

PMCID:: PMC5269510

Abstract Article PDF–3.3M

Select item 496031415.

Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

Marisa A. P. Baptista, Marton Keszei, Mariana Oliveira, Karen K. S. Sunahara, John Andersson, Carin I. M. Dahlberg, Austen J. Worth, Agne Liedén, I-Chun Kuo, Robert P. A. Wallin, Scott B. Snapper, Liv Eidsmo, Annika Scheynius, Mikael C. I. Karlsson, Gerben Bouma, Siobhan O. Burns, Mattias N. E. Forsell, Adrian J. Thrasher, Susanne Nylén, Lisa S. Westerberg

Nat Commun. 2016; 7: 12175. Published online 2016 Jul 18. doi: 10.1038/ncomms12175

PMCID:: PMC4960314

Abstract Article PDF–2.7M

Select item 482680116.

Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo

Meiling Zhu, Ben-hua Sun, Katarzyna Saar, Christine Simpson, Nancy Troiano, Sarah L Dallas, LeAnn M Tiede-Lewis, Erin Nevius, João P Pereira, Robert S Weinstein, Steven M Tommasini, Karl L Insogna

J Bone Miner Res. Author manuscript; available in PMC 2016 Apr 10.

Published in final edited form as: J Bone Miner Res. 2016 Apr; 31(4): 864–873. Published online 2015 Nov 18. doi: 10.1002/jbmr.2733

PMCID:: PMC4826801

Abstract Article PDF–488K

Select item 432677417.

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation

Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, Heidi C. E. Welch

Blood. 2015 Feb 12; 125(7): 1146–1158. Prepublished online 2014 Dec 23. doi: 10.1182/blood-2014-07-591040

PMCID:: PMC4326774

Abstract Article

Select item 431955918.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 417221919.

Chemokine-coupled β₂ integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis

Alan R. Morrison, Timur O. Yarovinsky, Bryan D. Young, Filipa Moraes, Tyler D. Ross, Nicolle Ceneri, Jiasheng Zhang, Zhen W. Zhuang, Albert J. Sinusas, Ruggero Pardi, Martin A. Schwartz, Michael Simons, Jeffrey R. Bender

J Exp Med. 2014 Sep 22; 211(10): 1957–1968. doi: 10.1084/jem.20132130

PMCID:: PMC4172219

Abstract Article PDF–2.5M

Select item 408267220.

Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis

Narcy Arizmendi, Lakshmi Puttagunta, Kerri L Chung, Courtney Davidson, Juliana Rey-Parra, Danny V Chao, Bernard Thebaud, Paige Lacy, Harissios Vliagoftis

Respir Res. 2014; 15(1): 71. Published online 2014 Jun 27. doi: 10.1186/1465-9921-15-71

PMCID:: PMC4082672

Abstract Article PDF–3.1M

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