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Select item 109168661.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 107999412.

Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα

Kentaro Hata, Kazuya Tsubouchi, Kunihiro Suzuki, Daisuke Eto, Hiroyuki Ando, Toyoshi Yanagihara, Keiko Kan-o, Isamu Okamoto

Sci Rep. 2024; 14: 1799. Published online 2024 Jan 20. doi: 10.1038/s41598-024-52328-5

PMCID:: PMC10799941

Abstract Article PDF–2.3M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 97325254.

Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis

Bhupesh Singla, Hui-Ping Lin, WonMo Ahn, Jiean Xu, Qian Ma, Moses Sghayyer, Kunzhe Dong, Mary Cherian-Shaw, Jiliang Zhou, Yuqing Huo, Joseph White, Gábor Csányi

Cardiovasc Res. 2022 Nov; 118(15): 3097–3111. Published online 2021 Dec 23. doi: 10.1093/cvr/cvab369

PMCID:: PMC9732525

Abstract Article PDF–2.9M

Select item 95354275.

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis

Di Wang, Yunkai Lin, Feihong Xu, Hui Zhang, Xiaoyan Zhu, Zhen Liu, Yuan Hu, Guanjun Dong, Bingqi Sun, Yanhong Yu, Guoren Ma, Zhigang Tang, Diana Legarda, Adrian Ting, Yuan Liu, Jia Hou, Liwei Dong, Huabao Xiong

eBioMedicine. 2022 Nov; 85: 104278. Published online 2022 Oct 3. doi: 10.1016/j.ebiom.2022.104278

PMCID:: PMC9535427

Abstract Article PDF–5.0M

Select item 92524366.

CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Françoise Gondois-Rey, Thomas Miller, Vladimir Laletin, Xavier Morelli, Yves Collette, Jacques Nunès, Daniel Olive

Front Immunol. 2022; 13: 899068. Published online 2022 Jun 20. doi: 10.3389/fimmu.2022.899068

PMCID:: PMC9252436

Abstract Article PDF–2.7M

Select item 89515567.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 86691448.

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha

Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Isabelle Scheyltjens, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, Geert Raes

Front Immunol. 2021; 12: 777524. Published online 2021 Nov 30. doi: 10.3389/fimmu.2021.777524

PMCID:: PMC8669144

Abstract Article PDF–7.9M

Select item 85266729.

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer

Yahui Zhao, Weina Zhang, Miaomiao Huo, Peng Wang, Xianghe Liu, Yu Wang, Yinuo Li, Zhixiang Zhou, Ningzhi Xu, Hongxia Zhu

Signal Transduct Target Ther. 2021; 6: 357. Published online 2021 Oct 20. doi: 10.1038/s41392-021-00761-7

PMCID:: PMC8526672

Abstract Article PDF–6.3M

Select item 841672410.

CD47/SIRPα pathway mediates cancer immune escape and immunotherapy

Xiao Jia, Bingjun Yan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi, Yongzhong Hou

Int J Biol Sci. 2021; 17(13): 3281–3287. Published online 2021 Jul 25. doi: 10.7150/ijbs.60782

PMCID:: PMC8416724

Abstract Article PDF–1.0M

Select item 836418111.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 835389912.

Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma

Naomichi Koga, Qingjiang Hu, Akihiro Sakai, Kazuki Takada, Ryota Nakanishi, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Eiji Oki, Yoshinao Oda, Masaki Mori

Cancer Sci. 2021 Aug; 112(8): 3018–3028. Published online 2021 Jun 11. doi: 10.1111/cas.14971

PMCID:: PMC8353899

Abstract Article PDF–1.6M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 797597814.

Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer

Akane Sugimura-Nagata, Akira Koshino, Satoshi Inoue, Aya Matsuo-Nagano, Masayuki Komura, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Satoru Takahashi, Kunio Kasugai, Kenji Kasai, Shingo Inaguma

Int J Mol Sci. 2021 Mar; 22(5): 2690. Published online 2021 Mar 7. doi: 10.3390/ijms22052690

PMCID:: PMC7975978

Abstract Article PDF–2.6M

Select item 734053915.

The CD47-SIRPα immune checkpoint

Meike E.W. Logtenberg, Ferenc A. Scheeren, Ton N. Schumacher

Immunity. Author manuscript; available in PMC 2021 May 19.

Published in final edited form as: Immunity. 2020 May 19; 52(5): 742–752. doi: 10.1016/j.immuni.2020.04.011

PMCID:: PMC7340539

Abstract Article PDF–1.0M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 711768217.

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

PLoS One. 2020; 15(4): e0226661. Published online 2020 Apr 2. doi: 10.1371/journal.pone.0226661

PMCID:: PMC7117682

Abstract Article PDF–2.0M

Select item 702588918.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and target for cancer immunotherapy

Meike E. W. Logtenberg, J. H. Marco Jansen, Matthijs Raaben, Mireille Toebes, Katka Franke, Arianne M. Brandsma, Hanke L. Matlung, Astrid Fauster, Raquel Gomez-Eerland, Noor A. M. Bakker, Simone van der Schot, Koen A. Marijt, Martijn Verdoes, John B. A. G. Haanen, Joost H. van den Berg, Jacques Neefjes, Timo K. van den Berg, Thijn R. Brummelkamp, Jeanette H. W. Leusen, Ferenc A. Scheeren, Ton N. Schumacher

Nat Med. Author manuscript; available in PMC 2020 Feb 17.

Published in final edited form as: Nat Med. 2019 Apr; 25(4): 612–619. Published online 2019 Mar 4. doi: 10.1038/s41591-019-0356-z

PMCID:: PMC7025889

Abstract Article PDF–4.3M

Select item 690344619.

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

Jiao Wu, Jiangling Dong, Daniela Verzola, Keith Hruska, Giacomo Garibotto, Zhaoyong Hu, William E. Mitch, Sandhya S. Thomas

J Cachexia Sarcopenia Muscle. 2019 Dec; 10(6): 1210–1227. Published online 2019 Sep 11. doi: 10.1002/jcsm.12459

PMCID:: PMC6903446

Abstract Article PDF–4.4M

Select item 679687220.

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

Zhiqiang Wu, Linjun Weng, Tengbo Zhang, Hongling Tian, Lan Fang, Hongqi Teng, Wen Zhang, Jing Gao, Yun Hao, Yaxu Li, Hu Zhou, Ping Wang

Cell Res. 2019 Jun; 29(6): 502–505. Published online 2019 May 14. doi: 10.1038/s41422-019-0177-0

PMCID:: PMC6796872

Article PDF–1.0M

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