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Items: 1 to 20 of 59

1.
CST–Polymeraseα-primase solves a second telomere end-replication problem
Hiroyuki Takai, Valentina Aria, Pamela Borges, Joseph T. P. Yeeles, Titia de Lange
Nature. Author manuscript; available in PMC 2024 Jun 7.
Published in final edited form as: Nature. 2024 Mar; 627(8004): 664–670. Published online 2024 Feb 28. doi: 10.1038/s41586-024-07137-1
PMCID:
PMC11160940
AbstractArticlePDF–2.4M
2.
CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection
Rishi Kumar Jaiswal, Kai-Hang Lei, Megan Chastain, Yuan Wang, Olga Shiva, Shan Li, Zhongsheng You, Peter Chi, Weihang Chai
Nat Commun. 2023; 14: 7882. Published online 2023 Nov 30. doi: 10.1038/s41467-023-43685-2
PMCID:
PMC10689503
AbstractArticlePDF–5.2M
3.
Structures of the human CST-Polα–primase complex bound to telomere templates
Qixiang He, Xiuhua Lin, Bianca L. Chavez, Sourav Agrawal, Benjamin L. Lusk, Ci Ji Lim
Nature. Author manuscript; available in PMC 2023 Jun 15.
Published in final edited form as: Nature. 2022 Aug; 608(7924): 826–832. Published online 2022 Jul 13. doi: 10.1038/s41586-022-05040-1
PMCID:
PMC10268231
AbstractArticlePDF–6.4M
4.
Reconstitution of a telomeric replicon organized by CST
Arthur J. Zaug, Karen J. Goodrich, Jessica J. Song, Ashley E. Sullivan, Thomas R. Cech
Nature. 2022; 608(7924): 819–825. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04930-8
PMCID:
PMC9402439
AbstractArticlePDF–29M
5.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
6.
Novel compound heterozygous STN1 variants are associated with Coats Plus syndrome
Tanvi Acharya, Helen V. Firth, Shilpa Dugar, Tassos Grammatikopoulos, Luis Seabra, Angharad Walters, Yanick J. Crow, Alasdair P. J. Parker
Mol Genet Genomic Med. 2021 Dec; 9(12): e1708. Published online 2021 Jun 10. doi: 10.1002/mgg3.1708
PMCID:
PMC8683631
AbstractArticlePDF–906K
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
9.
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Xuling Chang, Resham L. Gurung, Ling Wang, Aizhen Jin, Zheng Li, Renwei Wang, Kenneth B. Beckman, Jennifer Adams-Haduch, Wee Yang Meah, Kar Seng Sim, Weng Khong Lim, Sonia Davila, Patrick Tan, Jing Xian Teo, Khung Keong Yeo, Yiamunaa M., Sylvia Liu, Su Chi Lim, Jianjun Liu, Rob M. van Dam, Yechiel Friedlander, Woon-Puay Koh, Jian-Min Yuan, Chiea Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo
Commun Biol. 2021; 4: 519. Published online 2021 May 3. doi: 10.1038/s42003-021-02056-7
PMCID:
PMC8093266
AbstractArticlePDF–1009K
10.
CST in maintaining genome stability: beyond telomeres
Xinxing Lyu, Pau Biak Sang, Weihang Chai
DNA Repair (Amst) Author manuscript; available in PMC 2022 Jun 1.
Published in final edited form as: DNA Repair (Amst). 2021 Jun; 102: 103104. Published online 2021 Mar 22. doi: 10.1016/j.dnarep.2021.103104
PMCID:
PMC8081025
AbstractArticlePDF–903K
11.
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
Xinxing Lyu, Kai‐Hang Lei, Pau Biak Sang, Olga Shiva, Megan Chastain, Peter Chi, Weihang Chai
EMBO J. 2021 Jan 15; 40(2): e103654. Published online 2020 Nov 19. doi: 10.15252/embj.2019103654
PMCID:
PMC7809791
AbstractArticlePDF–4.5M
12.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
13.
Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB
Stephanie Wang, Emily Chang, Patrick Byanyima, Peter Huang, Ingvar Sanyu, Emmanuel Musisi, Abdul Sessolo, J. Lucian Davis, William Worodria, Laurence Huang, Jue Lin, Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study
J Hum Genet. Author manuscript; available in PMC 2020 Feb 24.
Published in final edited form as: J Hum Genet. 2019 Oct; 64(10): 1033–1040. Published online 2019 Aug 6. doi: 10.1038/s10038-019-0646-9
PMCID:
PMC7039711
AbstractArticlePDF–470K
14.
Mammalian CST averts replication failure by preventing G-quadruplex accumulation
Miaomiao Zhang, Bing Wang, Tingfang Li, Rui Liu, Yingnan Xiao, Xin Geng, Guang Li, Qiang Liu, Carolyn M Price, Yang Liu, Feng Wang
Nucleic Acids Res. 2019 Jun 4; 47(10): 5243–5259. Published online 2019 Apr 12. doi: 10.1093/nar/gkz264
PMCID:
PMC6547417
AbstractArticlePDF–6.9M
15.
Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents
Kaishun Hu, Wenjing Wu, Yu Li, Lehang Lin, Dong Chen, Haiyan Yan, Xing Xiao, Hengxing Chen, Zhen Chen, Yin Zhang, Shuangbing Xu, Yabin Guo, H Phillip Koeffler, Erwei Song, Dong Yin
EMBO Rep. 2019 May; 20(5): e46166. Published online 2019 Apr 2. doi: 10.15252/embr.201846166
PMCID:
PMC6500972
AbstractArticlePDF–4.2M
16.
Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
Yilin Wang, Kathryn S Brady, Benjamin P Caiello, Stephanie M Ackerson, Jason A Stewart
Life Sci Alliance. 2019 Apr; 2(2): e201800270. Published online 2019 Apr 12. doi: 10.26508/lsa.201800270
PMCID:
PMC6464128
AbstractArticlePDF–2.5M
17.
Emerging roles of CST in maintaining genome stability and human disease
Jason A. Stewart, Yilin Wang, Stephanie M. Ackerson, P. Logan Schuck
Front Biosci (Landmark Ed) Author manuscript; available in PMC 2018 Dec 28.
Published in final edited form as: Front Biosci (Landmark Ed). 2018 Mar 1; 23: 1564–1586. Published online 2018 Mar 1. doi: 10.2741/4661
PMCID:
PMC6309963
AbstractArticlePDF–1.2M
18.
Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function
Victoria Torrance, David Lydall
PLoS Genet. 2018 Aug; 14(8): e1007523. Published online 2018 Aug 1. doi: 10.1371/journal.pgen.1007523
PMCID:
PMC6089452
AbstractArticlePDF–6.2M
19.
53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in
Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange
Nature. Author manuscript; available in PMC 2019 Jan 18.
Published in final edited form as: Nature. 2018 Aug; 560(7716): 112–116. Published online 2018 Jul 18. doi: 10.1038/s41586-018-0324-7
PMCID:
PMC6072559
AbstractArticlePDF–1.8M
20.
CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
Xuyang Feng, Shih-Jui Hsu, Anukana Bhattacharjee, Yongyao Wang, Jiajie Diao, Carolyn M. Price
Nat Commun. 2018; 9: 2827. Published online 2018 Jul 19. doi: 10.1038/s41467-018-05154-z
PMCID:
PMC6053418
AbstractArticlePDF–1.4M

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