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Items: 1 to 20 of 208

1.
Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF‐mediated Bcl‐x exon 2b inclusion
Shuqiang Zhang, Junjie Zhong, Lian Xu, Yue Wu, Jie Xu, Jianhua Shi, Zhikai Gu, Xiaoyu Li, Nana Jin
CNS Neurosci Ther. 2024 Apr; 30(4): e14493. Published online 2023 Oct 21. doi: 10.1111/cns.14493
PMCID:
PMC11017436
AbstractArticlePDF–12M
2.
Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth
Anita Bodac, Abdullah Mayet, Sarika Rana, Justine Pascual, Amber D Bowler, Vincent Roh, Nadine Fournier, Ligia Craciun, Pieter Demetter, Freddy Radtke, Etienne Meylan
EMBO Mol Med. 2024 Jan; 16(1): 158–184. Published online 2023 Dec 20. doi: 10.1038/s44321-023-00013-x
PMCID:
PMC10897164
AbstractArticlePDF–8.1M
3.
Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis
Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori
Int J Mol Sci. 2023 Dec; 24(24): 17319. Published online 2023 Dec 10. doi: 10.3390/ijms242417319
PMCID:
PMC10743571
AbstractArticlePDF–3.7M
4.
Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice
Michinari Nakamura, Mariko Aoyagi Keller, Nadezhda Fefelova, Peiyong Zhai, Tong Liu, Yimin Tian, Shohei Ikeda, Dominic P. Del Re, Hong Li, Lai-Hua Xie, Junichi Sadoshima
Nat Commun. 2023; 14: 5805. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41595-x
PMCID:
PMC10509265
AbstractArticlePDF–5.8M
5.
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang
Nat Commun. 2023; 14: 2731. Published online 2023 May 12. doi: 10.1038/s41467-023-38471-z
PMCID:
PMC10175245
AbstractArticlePDF–6.7M
6.
BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis
Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alex Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm
Cell Rep. Author manuscript; available in PMC 2023 Mar 21.
Published in final edited form as: Cell Rep. 2022 Dec 20; 41(12): 111826. doi: 10.1016/j.celrep.2022.111826
PMCID:
PMC10030045
AbstractArticlePDF–4.7M
7.
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
Hajrah Khawaja, Rebecca Briggs, Cheryl H. Latimer, Mustasin Rassel, Daryl Griffin, Lyndsey Hanson, Alberto Bardelli, Frederica Di Nicolantonio, Simon S. McDade, Christopher J. Scott, Shauna Lambe, Manisha Maurya, Andreas U. Lindner, Jochen H.M. Prehn, Jose Sousa, Chris Winnington, Melissa J. LaBonte, Sarah Ross, Sandra Van Schaeybroeck
Mol Cancer Ther. 2023 Jan 3; 22(1): 135–149. Published online 2022 Oct 22. doi: 10.1158/1535-7163.MCT-22-0301
PMCID:
PMC9808374
AbstractArticlePDF–16M
8.
Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death
Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5
PMCID:
PMC9091217
AbstractArticlePDF–7.2M
9.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
10.
Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation
Mehmet Mahsum Kaplan, Bernhard E. Flucher
iScience. 2022 Apr 15; 25(4): 104025. Published online 2022 Mar 4. doi: 10.1016/j.isci.2022.104025
PMCID:
PMC8941212
AbstractArticlePDF–6.5M
11.
CDNF and MANF regulate ER stress in a tissue-specific manner
Emmi Pakarinen, Päivi Lindholm, Mart Saarma, Maria Lindahl
Cell Mol Life Sci. 2022 Feb; 79(2): 124. Published online 2022 Feb 7. doi: 10.1007/s00018-022-04157-w
PMCID:
PMC8821067
AbstractArticlePDF–5.4M
12.
Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms
Hisashi Takei, Juan Luiz Coelho‐Silva, Cristina Tavares Leal, Adriana Queiroz Arantes Rocha, Thiago Mantello Bianco, Robert S. Welner, Yuta Mishima, Ikei S. Kobayashi, Ann Mullally, Keli Lima, João Agostinho Machado‐Neto, Susumu S. Kobayashi, Lorena Lobo de Figueiredo‐Pontes
Cancer Sci. 2022 Feb; 113(2): 597–608. Published online 2021 Dec 15. doi: 10.1111/cas.15210
PMCID:
PMC8819353
AbstractArticlePDF–1.8M
13.
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang, Tingxiu Xiang
J Exp Clin Cancer Res. 2021; 40: 150. Published online 2021 Apr 30. doi: 10.1186/s13046-021-01948-0
PMCID:
PMC8086320
AbstractArticlePDF–8.8M
14.
RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-xL in developing thymocytes
Davinna L. Ligons, SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park
Sci Signal. Author manuscript; available in PMC 2021 Apr 21.
Published in final edited form as: Sci Signal. 2018 Aug 28; 11(545): eaam8939. Published online 2018 Aug 28. doi: 10.1126/scisignal.aam8939
PMCID:
PMC8058635
AbstractArticlePDF–1.5M
15.
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis
Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Cell Death Dis. 2021 Apr; 12(4): 406. Published online 2021 Apr 15. doi: 10.1038/s41419-021-03668-x
PMCID:
PMC8050302
AbstractArticlePDF–3.2M
16.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
17.
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage
Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser
EMBO J. 2020 Dec 15; 39(24): e105561. Published online 2020 Nov 25. doi: 10.15252/embj.2020105561
PMCID:
PMC7737616
AbstractArticlePDF–3.8M
18.
Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori
PLoS Genet. 2020 Nov; 16(11): e1009169. Published online 2020 Nov 30. doi: 10.1371/journal.pgen.1009169
PMCID:
PMC7728394
AbstractArticlePDF–10M
19.
Cardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling
Yuanjun Guo, Jennifer Y. Sui, Kyungsoo Kim, Zhentao Zhang, Xiaoyan A. Qu, Young-Jae Nam, Robert N. Willette, Joey V. Barnett, Bjorn C. Knollmann, Thomas Force, Hind Lal
Circulation. Author manuscript; available in PMC 2020 Nov 26.
Published in final edited form as: Circulation. 2019 Nov 26; 140(22): 1820–1833. Published online 2019 Oct 4. doi: 10.1161/CIRCULATIONAHA.119.040740
PMCID:
PMC7219521
AbstractArticlePDF–4.5M
20.
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer
Paul M. Nguyen, Laura F. Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K. Yip, Christopher G. Love, Ashleigh R. Poh, Akshay D’ Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M. Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, Matthias Ernst, Andrew I. Webb, Tony Burgess, Oliver M. Sieber, Philippe Bouillet, Tracy L. Putoczki
Cell Death Differ. 2020 Feb; 27(2): 742–757. Published online 2019 Jul 11. doi: 10.1038/s41418-019-0383-9
PMCID:
PMC7206067
AbstractArticlePDF–3.9M

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