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Select item 110174361.

Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF‐mediated Bcl‐x exon 2b inclusion

Shuqiang Zhang, Junjie Zhong, Lian Xu, Yue Wu, Jie Xu, Jianhua Shi, Zhikai Gu, Xiaoyu Li, Nana Jin

CNS Neurosci Ther. 2024 Apr; 30(4): e14493. Published online 2023 Oct 21. doi: 10.1111/cns.14493

PMCID:: PMC11017436

Abstract Article PDF–12M

Select item 108971642.

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Anita Bodac, Abdullah Mayet, Sarika Rana, Justine Pascual, Amber D Bowler, Vincent Roh, Nadine Fournier, Ligia Craciun, Pieter Demetter, Freddy Radtke, Etienne Meylan

EMBO Mol Med. 2024 Jan; 16(1): 158–184. Published online 2023 Dec 20. doi: 10.1038/s44321-023-00013-x

PMCID:: PMC10897164

Abstract Article PDF–8.1M

Select item 107435713.

Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis

Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori

Int J Mol Sci. 2023 Dec; 24(24): 17319. Published online 2023 Dec 10. doi: 10.3390/ijms242417319

PMCID:: PMC10743571

Abstract Article PDF–3.7M

Select item 105092654.

Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice

Michinari Nakamura, Mariko Aoyagi Keller, Nadezhda Fefelova, Peiyong Zhai, Tong Liu, Yimin Tian, Shohei Ikeda, Dominic P. Del Re, Hong Li, Lai-Hua Xie, Junichi Sadoshima

Nat Commun. 2023; 14: 5805. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41595-x

PMCID:: PMC10509265

Abstract Article PDF–5.8M

Select item 101752455.

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Ruifan Wu, Jooman Park, Yanyu Qian, Zuoxiao Shi, Ruoci Hu, Yexian Yuan, Shaolei Xiong, Zilai Wang, Gege Yan, Sang-Ging Ong, Qing Song, Zhenyuan Song, Abeer M. Mahmoud, Pingwen Xu, Congcong He, Robert W. Arpke, Michael Kyba, Gang Shu, Qingyan Jiang, Yuwei Jiang

Nat Commun. 2023; 14: 2731. Published online 2023 May 12. doi: 10.1038/s41467-023-38471-z

PMCID:: PMC10175245

Abstract Article PDF–6.7M

Select item 100300456.

BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis

Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alex Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm

Cell Rep. Author manuscript; available in PMC 2023 Mar 21.

Published in final edited form as: Cell Rep. 2022 Dec 20; 41(12): 111826. doi: 10.1016/j.celrep.2022.111826

PMCID:: PMC10030045

Abstract Article PDF–4.7M

Select item 98083747.

Bcl-xL Is a Key Mediator of Apoptosis Following KRAS^G12C Inhibition in KRAS^G12C-mutant Colorectal Cancer

Hajrah Khawaja, Rebecca Briggs, Cheryl H. Latimer, Mustasin Rassel, Daryl Griffin, Lyndsey Hanson, Alberto Bardelli, Frederica Di Nicolantonio, Simon S. McDade, Christopher J. Scott, Shauna Lambe, Manisha Maurya, Andreas U. Lindner, Jochen H.M. Prehn, Jose Sousa, Chris Winnington, Melissa J. LaBonte, Sarah Ross, Sandra Van Schaeybroeck

Mol Cancer Ther. 2023 Jan 3; 22(1): 135–149. Published online 2022 Oct 22. doi: 10.1158/1535-7163.MCT-22-0301

PMCID:: PMC9808374

Abstract Article PDF–16M

Select item 90912178.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 90145599.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 894121210.

Counteractive and cooperative actions of muscle β-catenin and Ca_V1.1 during early neuromuscular synapse formation

Mehmet Mahsum Kaplan, Bernhard E. Flucher

iScience. 2022 Apr 15; 25(4): 104025. Published online 2022 Mar 4. doi: 10.1016/j.isci.2022.104025

PMCID:: PMC8941212

Abstract Article PDF–6.5M

Select item 882106711.

CDNF and MANF regulate ER stress in a tissue-specific manner

Emmi Pakarinen, Päivi Lindholm, Mart Saarma, Maria Lindahl

Cell Mol Life Sci. 2022 Feb; 79(2): 124. Published online 2022 Feb 7. doi: 10.1007/s00018-022-04157-w

PMCID:: PMC8821067

Abstract Article PDF–5.4M

Select item 881935312.

Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms

Hisashi Takei, Juan Luiz Coelho‐Silva, Cristina Tavares Leal, Adriana Queiroz Arantes Rocha, Thiago Mantello Bianco, Robert S. Welner, Yuta Mishima, Ikei S. Kobayashi, Ann Mullally, Keli Lima, João Agostinho Machado‐Neto, Susumu S. Kobayashi, Lorena Lobo de Figueiredo‐Pontes

Cancer Sci. 2022 Feb; 113(2): 597–608. Published online 2021 Dec 15. doi: 10.1111/cas.15210

PMCID:: PMC8819353

Abstract Article PDF–1.8M

Select item 808632013.

ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis

Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang, Tingxiu Xiang

J Exp Clin Cancer Res. 2021; 40: 150. Published online 2021 Apr 30. doi: 10.1186/s13046-021-01948-0

PMCID:: PMC8086320

Abstract Article PDF–8.8M

Select item 805863514.

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x_L in developing thymocytes

Davinna L. Ligons, SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park

Sci Signal. Author manuscript; available in PMC 2021 Apr 21.

Published in final edited form as: Sci Signal. 2018 Aug 28; 11(545): eaam8939. Published online 2018 Aug 28. doi: 10.1126/scisignal.aam8939

PMCID:: PMC8058635

Abstract Article PDF–1.5M

Select item 805030215.

Malignant pleural mesothelioma co-opts BCL-X_L and autophagy to escape apoptosis

Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng

Cell Death Dis. 2021 Apr; 12(4): 406. Published online 2021 Apr 15. doi: 10.1038/s41419-021-03668-x

PMCID:: PMC8050302

Abstract Article PDF–3.2M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 773761617.

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

EMBO J. 2020 Dec 15; 39(24): e105561. Published online 2020 Nov 25. doi: 10.15252/embj.2020105561

PMCID:: PMC7737616

Abstract Article PDF–3.8M

Select item 772839418.

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts

Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori

PLoS Genet. 2020 Nov; 16(11): e1009169. Published online 2020 Nov 30. doi: 10.1371/journal.pgen.1009169

PMCID:: PMC7728394

Abstract Article PDF–10M

Select item 721952119.

Cardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling

Yuanjun Guo, Jennifer Y. Sui, Kyungsoo Kim, Zhentao Zhang, Xiaoyan A. Qu, Young-Jae Nam, Robert N. Willette, Joey V. Barnett, Bjorn C. Knollmann, Thomas Force, Hind Lal

Circulation. Author manuscript; available in PMC 2020 Nov 26.

Published in final edited form as: Circulation. 2019 Nov 26; 140(22): 1820–1833. Published online 2019 Oct 4. doi: 10.1161/CIRCULATIONAHA.119.040740

PMCID:: PMC7219521

Abstract Article PDF–4.5M

Select item 720606720.

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M. Nguyen, Laura F. Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K. Yip, Christopher G. Love, Ashleigh R. Poh, Akshay D’ Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M. Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, Matthias Ernst, Andrew I. Webb, Tony Burgess, Oliver M. Sieber, Philippe Bouillet, Tracy L. Putoczki

Cell Death Differ. 2020 Feb; 27(2): 742–757. Published online 2019 Jul 11. doi: 10.1038/s41418-019-0383-9

PMCID:: PMC7206067

Abstract Article PDF–3.9M

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