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Select item 113030711.

ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation

Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen

Theranostics. 2024; 14(11): 4536–4553. Published online 2024 Jul 22. doi: 10.7150/thno.95796

PMCID:: PMC11303071

Abstract Article PDF–15M

Select item 101838272.

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation

Chuannan Fan, Qian Wang, Thomas B Kuipers, Davy Cats, Prasanna Vasudevan Iyengar, Sophie C Hagenaars, Wilma E Mesker, Peter Devilee, Rob A E M Tollenaar, Hailiang Mei, Peter ten Dijke

EMBO J. 2023 May; 42(10): e112806. Published online 2023 Mar 30. doi: 10.15252/embj.2022112806

PMCID:: PMC10183827

Abstract Article PDF–5.6M

Select item 101721883.

Truncating variants in the penultimate exon of TGFBR1 escaping nonsense-mediated mRNA decay cause Loeys-Dietz syndrome

Paola Fortugno, Rosanna Monetta, Valeria Cinquina, Chiara Rigon, Francesca Boaretto, Chiara De Luca, Nicoletta Zoppi, Luana Di Leandro, Emanuela De Domenico, Arianna Di Daniele, Rodolfo Ippoliti, Francesco Angelucci, Ernesto Di Cesare, Ruggero De Paulis, Leonardo Salviati, Marina Colombi, Francesco Brancati, Marco Ritelli

Eur J Hum Genet. 2023 May; 31(5): 596–601. Published online 2023 Jan 4. doi: 10.1038/s41431-022-01279-4

PMCID:: PMC10172188

Abstract Article PDF–5.0M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100653255.

Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis

Karina Colombera Peres, Larissa Teodoro, Laís Helena Pereira Amaral, Elisângela Souza Teixeira, Icléia Siqueira Barreto, Leandro Luiz Lopes de Freitas, Valdemar Maximo, Lígia V. Montalli Assumpção, Natassia Elena Bufalo, Laura Sterian Ward

Arch Endocrinol Metab. 2021 Mar-Apr; 65(2): 172–184. Published online 2021 Feb 25. doi: 10.20945/2359-3997000000330

PMCID:: PMC10065325

Abstract Article PDF–421K

Select item 100366706.

Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells

Xinyue Li, Navneet Kaur, Mustafa Albahrani, Adam R. Karpf, Adrian R. Black, Jennifer D. Black

J Biol Chem. 2023 Apr; 299(4): 103017. Published online 2023 Feb 13. doi: 10.1016/j.jbc.2023.103017

PMCID:: PMC10036670

Abstract Article PDF–1.6M

Select item 99901787.

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Zhi-yuan Zhang, Cui-yu Ju, Liu-zheng Wu, Han Yan, Wen-bin Hong, Hang-zi Chen, Peng-bo Yang, Bao-Rui Wang, Tong Gou, Xiao-yan Chen, Zhi-hong Jiang, Wei-jia Wang, Tianwei Lin, Fu-nan Li, Qiao Wu

Cell Chem Biol. 2023 Mar 16; 30(3): 261–277.e8. Published online 2023 Mar 7. doi: 10.1016/j.chembiol.2023.02.004

PMCID:: PMC9990178

Abstract Article PDF–6.9M

Select item 98887568.

Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes

Alanna Strong, Cara Skraban, Kevin Meyers, Sandra Amaral, Susan Furth, Stacey Drant, Wendy Hsiao, Lauren Galea, Jessica Gold, Nina B. Gold, Jacqueline Leonard, Sonya Lopez, Elaine H. Zackai, Reed E. Pyeritz

Am J Med Genet A. Author manuscript; available in PMC 2023 Jan 31.

Published in final edited form as: Am J Med Genet A. 2021 Dec; 185(12): 3762–3769. Published online 2021 Aug 6. doi: 10.1002/ajmg.a.62449

PMCID:: PMC9888756

Abstract Article PDF–1.0M

Select item 98425919.

Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial–mesenchymal transition of breast cancer cells

Jing Zhang, Maarten van Dinther, Midory Thorikay, Babak Mousavi Gourabi, Boudewijn P. T. Kruithof, Peter ten Dijke

Cell Mol Life Sci. 2023 Feb; 80(2): 43. Published online 2023 Jan 17. doi: 10.1007/s00018-022-04672-w

PMCID:: PMC9842591

Abstract Article PDF–14M

Select item 952876010.

GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways

Jan Frohlich, Kristina Kovacovicova, Marco Raffaele, Tereza Virglova, Eliska Cizkova, Jan Kucera, Julie Bienertova‐Vasku, Martin Wabitsch, Marion Peyrou, Francesca Bonomini, Rita Rezzani, George N. Chaldakov, Anton B. Tonchev, Michelino Di Rosa, Nicolas Blavet, Vaclav Hejret, Manlio Vinciguerra

Cell Prolif. 2022 Oct; 55(10): e13310. Published online 2022 Aug 3. doi: 10.1111/cpr.13310

PMCID:: PMC9528760

Abstract Article PDF–3.7M

Select item 938672611.

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Jie Song, Yang Zhou, Ihor Yakymovych, Alexej Schmidt, Chunyan Li, Carl-Henrik Heldin, Maréne Landström

eBioMedicine. 2022 Aug; 82: 104155. Published online 2022 Jul 16. doi: 10.1016/j.ebiom.2022.104155

PMCID:: PMC9386726

Abstract Article PDF–5.3M

Select item 923162312.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 920157213.

Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction

Junju Zou, Xiaotao Zhou, Xian Chen, Yuerong Ma, Rong Yu

Front Pharmacol. 2022; 13: 849832. Published online 2022 Jun 2. doi: 10.3389/fphar.2022.849832

PMCID:: PMC9201572

Abstract Article PDF–7.1M

Select item 917141114.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973615.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 900518716.

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Michèle MG Hillege, Andi Shi, Ricardo A Galli, Gang Wu, Philippe Bertolino, Willem MH Hoogaars, Richard T Jaspers

eLife. 2022; 11: e77610. Published online 2022 Mar 24. doi: 10.7554/eLife.77610

PMCID:: PMC9005187

Abstract Article PDF–8.5M

Select item 894521117.

Role of TGF-Beta Signaling in Beta Cell Proliferation and Function in Diabetes

Hong-Lian Wang, Li Wang, Chang-Ying Zhao, Hui-Yao Lan

Biomolecules. 2022 Mar; 12(3): 373. Published online 2022 Feb 26. doi: 10.3390/biom12030373

PMCID:: PMC8945211

Abstract Article PDF–1.2M

Select item 890573518.

Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis

Wenbiao Chen, Feng Zhang, Xianliang Hou, Huixuan Xu, Donge Tang

Cell Commun Signal. 2022; 20: 28. Published online 2022 Mar 9. doi: 10.1186/s12964-022-00835-1

PMCID:: PMC8905735

Abstract Article PDF–11M

Select item 886447219.

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network

Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang

Mol Cell Proteomics. 2022 Feb; 21(2): 100195. Published online 2022 Jan 8. doi: 10.1016/j.mcpro.2022.100195

PMCID:: PMC8864472

Abstract Article PDF–3.6M

Select item 875267220.

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi

Commun Biol. 2022; 5: 22. Published online 2022 Jan 11. doi: 10.1038/s42003-021-02950-0

PMCID:: PMC8752672

Abstract Article PDF–3.3M

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