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Select item 110792161.

Identification of molecular subtypes based on chromatin regulator-related genes and experimental verification of the role of ASCL1 in conferring chemotherapy resistance to breast cancer

Yilun Li, Xiaolu Yang, Cuizhi Geng, Yunjiang Liu, Tiantian Tang, Lina Zhang, Fei Liu, Meng Zhang, Jun Hao, Li Ma

Front Immunol. 2024; 15: 1390261. Published online 2024 Apr 25. doi: 10.3389/fimmu.2024.1390261

PMCID:: PMC11079216

Abstract Article PDF–10M

Select item 107242322.

ASCL1 induces neurogenesis in human Müller glia

Juliette Wohlschlegel, Connor Finkbeiner, Dawn Hoffer, Faith Kierney, Aric Prieve, Alexandria D. Murry, Alexandra K. Haugan, Isabel Ortuño-Lizarán, Fred Rieke, Sam A. Golden, Thomas A. Reh

Stem Cell Reports. 2023 Dec 12; 18(12): 2400–2417. Published online 2023 Nov 30. doi: 10.1016/j.stemcr.2023.10.021

PMCID:: PMC10724232

Abstract Article PDF–8.5M

Select item 106482103.

ASCL1 Is Involved in the Pathogenesis of Schizophrenia by Regulation of Genes Related to Cell Proliferation, Neuronal Signature Formation, and Neuroplasticity

Dmitrii A. Abashkin, Dmitry S. Karpov, Artemii O. Kurishev, Ekaterina V. Marilovtseva, Vera E. Golimbet

Int J Mol Sci. 2023 Nov; 24(21): 15746. Published online 2023 Oct 30. doi: 10.3390/ijms242115746

PMCID:: PMC10648210

Abstract Article PDF–4.7M

Select item 105678354.

Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs

Jimei Zhang, Ling Zhu, Jianping Zhou, Qunying Yu, Guangyuan Yang, Ke Zhao, Chaoli Luo, Jianguo Meng, Jing Liu, Xuming Yang

In Vitro Cell Dev Biol Anim. 2023; 59(8): 636–648. Published online 2023 Oct 2. doi: 10.1007/s11626-023-00811-0

PMCID:: PMC10567835

Abstract Article PDF–11M

Select item 102366175.

An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1‐positive neuroendocrine carcinoma

Masafumi Horie, Hidenori Tanaka, Masami Suzuki, Yoshihiko Sato, So Takata, Erina Takai, Naoya Miyashita, Akira Saito, Yoichiro Nakatani, Shinichi Yachida

Cancer Sci. 2023 Jun; 114(6): 2596–2608. Published online 2023 Mar 15. doi: 10.1111/cas.15764

PMCID:: PMC10236617

Abstract Article PDF–3.5M

Select item 101118636.

Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

Oana Păun, Yu Xuan Tan, Harshil Patel, Stephanie Strohbuecker, Avinash Ghanate, Clementina Cobolli-Gigli, Miriam Llorian Sopena, Lina Gerontogianni, Robert Goldstone, Siew-Lan Ang, François Guillemot, Cristina Dias

Genes Dev. 2023 Mar 1; 37(5-6): 218–242. doi: 10.1101/gad.350269.122

PMCID:: PMC10111863

Abstract Article PDF–22M

Select item 99075557.

Validation of ASCL1 and LHX8 Methylation Analysis as Primary Cervical Cancer Screening Strategy in South African Women with Human Immunodeficiency Virus

Frederique J Vink, Chris J L M Meijer, Birgit I Lissenberg-Witte, Cathy Visser, Sylvia Duin, Leon C Snyman, Karin L Richter, Frederick H van der Merwe, Matthys H Botha, Renske D M Steenbergen, Greta Dreyer

Clin Infect Dis. 2023 Feb 1; 76(3): 416–423. Published online 2022 Nov 11. doi: 10.1093/cid/ciac801

PMCID:: PMC9907555

Abstract Article PDF–716K

Select item 96332988.

ASCL1 regulates super‐enhancer‐associated miRNAs to define molecular subtypes of small cell lung cancer

Kazuko Miyakawa, Naoya Miyashita, Masafumi Horie, Yasuhiro Terasaki, Hidenori Tanaka, Hirokazu Urushiyama, Kensuke Fukuda, Yugo Okabe, Takashi Ishii, Naomi Kuwahara, Hiroshi I. Suzuki, Takahide Nagase, Akira Saito

Cancer Sci. 2022 Nov; 113(11): 3932–3946. Published online 2022 Aug 30. doi: 10.1111/cas.15481

PMCID:: PMC9633298

Abstract Article PDF–5.3M

Select item 93485769.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 904628010.

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Shaghayegh Nouruzi, Dwaipayan Ganguli, Nakisa Tabrizian, Maxim Kobelev, Olena Sivak, Takeshi Namekawa, Daksh Thaper, Sylvan C. Baca, Matthew L. Freedman, Adeleke Aguda, Alastair Davies, Amina Zoubeidi

Nat Commun. 2022; 13: 2282. Published online 2022 Apr 27. doi: 10.1038/s41467-022-29963-5

PMCID:: PMC9046280

Abstract Article PDF–4.0M

Select item 899368911.

Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer

Natsumi Tsuboyama, Ru Wang, Aileen Patricia Szczepanski, Huanhuan Chen, Zibo Zhao, Lei Shi, Lu Wang

Oncogene. 2022; 41(15): 2152–2162. Published online 2022 Feb 22. doi: 10.1038/s41388-022-02240-x

PMCID:: PMC8993689

Abstract Article PDF–4.5M

Select item 883775812.

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation

Roberta Azzarelli, Aoibheann McNally, Claudia Dell’Amico, Marco Onorati, Benjamin Simons, Anna Philpott

Sci Rep. 2022; 12: 2341. Published online 2022 Feb 11. doi: 10.1038/s41598-022-06248-x

PMCID:: PMC8837758

Abstract Article PDF–4.4M

Select item 880725613.

ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China

Chunfang Hu, Jiyan Dong, Li Liu, Jingbo Liu, Xujie Sun, Fei Teng, Xin Wang, Jianming Ying, Junling Li, Puyuan Xing, Lin Yang

Thorac Cancer. 2022 Feb; 13(3): 338–345. Published online 2021 Dec 20. doi: 10.1111/1759-7714.14249

PMCID:: PMC8807256

Abstract Article PDF–1.5M

Select item 856164214.

Developmental programming and lineage branching of early human telencephalon

Lin Ma, Yanhua Du, Yi Hui, Nan Li, Beibei Fan, Xiaojie Zhang, Xiaocui Li, Wei Hong, Zhiping Wu, Shuwei Zhang, Shanshan Zhou, Xiangjie Xu, Zhongshu Zhou, Cizhong Jiang, Ling Liu, Xiaoqing Zhang

EMBO J. 2021 Nov 2; 40(21): e107277. Published online 2021 Sep 24. doi: 10.15252/embj.2020107277

PMCID:: PMC8561642

Abstract Article PDF–20M

Select item 836279715.

Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization

Marina K Baine, Min-Shu Hsieh, W. Victoria Lai, Jacklynn V. Egger, Achim Jungbluth, Yahya Daneshbod, Amanda Beras, Rowanne Spencer, Jessica Lopardo, Francis Bodd, Joseph Montecalvo, Jennifer L. Sauter, Jason C. Chang, Darren J. Buonocore, William D. Travis, Triparna Sen, John T. Poirier, Charles M. Rudin, Natasha Rekhtman

J Thorac Oncol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: J Thorac Oncol. 2020 Dec; 15(12): 1823–1835. Published online 2020 Oct 1. doi: 10.1016/j.jtho.2020.09.009

PMCID:: PMC8362797

Abstract Article PDF–1.8M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800904817.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 785449718.

Regulation of CEACAM5 and therapeutic efficacy of an anti-CEACAM5-SN38 antibody-drug conjugate in neuroendocrine prostate cancer

Diana C. DeLucia, Thomas M. Cardillo, Lisa Ang, Mark P. Labrecque, Ailin Zhang, James E. Hopkins, Navonil De Sarkar, Ilsa Coleman, Rui M. Gil da Costa, Eva Corey, Lawrence D. True, Michael C. Haffner, Michael T. Schweizer, Colm Morrissey, Peter S. Nelson, John K. Lee

Clin Cancer Res. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Clin Cancer Res. 2021 Feb 1; 27(3): 759–774. Published online 2020 Nov 16. doi: 10.1158/1078-0432.CCR-20-3396

PMCID:: PMC7854497

Abstract Article PDF–2.5M

Select item 777920219.

Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer

Jiacong Wei, Li Liu, Yiying Guo, Jinyao Zhang, Xin Wang, Jiyan Dong, Puyuan Xing, Jianming Ying, Lin Yang, Junling Li

Thorac Cancer. 2021 Jan; 12(1): 40–47. Published online 2020 Nov 15. doi: 10.1111/1759-7714.13705

PMCID:: PMC7779202

Abstract Article PDF–1.1M

Select item 761460320.

Dephosphorylation of the proneural transcription factor ASCL1 re-engages a latent post-mitotic differentiation programme in neuroblastoma

Fahad R. Ali, Daniel Marcos, Igor Chernukhin, Laura M. Woods, Lydia M. Parkinson, Luke A. Wylie, Tatiana D. Papkovskaia, John D. Davies, Jason S. Carroll, Anna Philpott

Mol Cancer Res. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Mol Cancer Res. 2020 Dec 1; 18(12): 1759–1766. Published online 2020 Oct 12. doi: 10.1158/1541-7786.MCR-20-0693

Correction in:: Mol Cancer Res. 2021 Sep; 19(9): 1609.

PMCID:: PMC7614603

Abstract Article PDF–1.5M

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