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Select item 109239481.

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence

Yaiza Potes, Juan C. Bermejo-Millo, Catarina Mendes, José P. Castelão-Baptista, Andrea Díaz-Luis, Zulema Pérez-Martínez, Juan J. Solano, Vilma A. Sardão, Paulo J. Oliveira, Beatriz Caballero, Ana Coto-Montes, Ignacio Vega-Naredo

Cell Death Dis. 2024 Mar; 15(3): 200. Published online 2024 Mar 8. doi: 10.1038/s41419-024-06582-0

PMCID:: PMC10923948

Abstract Article PDF–5.5M

Select item 109193052.

Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation

Yanmin Jiang, Lan Xu, Xue Zhu, Xiaowei Zhu, Xiang Xu, Jianbo Li

Redox Rep. 2024; 29(1): 2324234. Published online 2024 Mar 5. doi: 10.1080/13510002.2024.2324234

PMCID:: PMC10919305

Abstract Article PDF–1.4M

Select item 109175463.

The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung

Claudia F. Garcia Castro, Claudio Nardiello, Stefan Hadzic, Baktybek Kojonazarov, Simone Kraut, Mareike Gierhardt, Julia Schäffer, Mariola Bednorz, Karin Quanz, Jacqueline Heger, Martina Korfei, Jochen Wilhelm, Matthias Hecker, Marek Bartkuhn, Stefan Arnhold, Andreas Guenther, Werner Seeger, Rainer Schulz, Norbert Weissmann, Natascha Sommer, Oleg Pak

Aging Dis. 2024 Apr 1; 15(2): 911–926. Published online 2024 Apr 1. doi: 10.14336/AD.2023.0715

PMCID:: PMC10917546

Abstract Article PDF–1.5M

Select item 108833824.

p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation

Ludovica Lopresti, Nagaja Capitani, Vanessa Tatangelo, Carmela Tangredi, Gioia Boncompagni, Federica Frezzato, Andrea Visentin, Giuseppe Marotta, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Livio Trentin, Cosima T. Baldari, Laura Patrussi

Front Cell Dev Biol. 2024; 12: 1297116. Published online 2024 Jan 23. doi: 10.3389/fcell.2024.1297116

PMCID:: PMC10883382

Abstract Article PDF–2.8M

Select item 99004545.

SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc

Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin

Redox Biol. 2023 Apr; 60: 102615. Published online 2023 Jan 24. doi: 10.1016/j.redox.2023.102615

PMCID:: PMC9900454

Abstract Article PDF–16M

Select item 95129216.

USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion

Xinyao Tian, Yan Zhao, Zhe Yang, Qianrang Lu, Lin Zhou, Shusen Zheng

Cell Death Dis. 2022 Sep; 13(9): 823. Published online 2022 Sep 26. doi: 10.1038/s41419-022-05277-8

PMCID:: PMC9512921

Abstract Article PDF–5.4M

Select item 87523557.

Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone

Mareike Gierhardt, Oleg Pak, Akylbek Sydykov, Simone Kraut, Julia Schäffer, Claudia Garcia, Christine Veith, Esraa M Zeidan, Monika Brosien, Karin Quanz, Azadeh Esfandiary, Alireza Saraji, Stefan Hadzic, Baktybek Kojonazarov, Jochen Wilhelm, Hossein A Ghofrani, Ralph T Schermuly, Werner Seeger, Friedrich Grimminger, Christiane Herden, Rainer Schulz, Norbert Weissmann, Jacqueline Heger, Natascha Sommer

Cardiovasc Res. 2022 Jan; 118(1): 305–315. Published online 2020 Oct 29. doi: 10.1093/cvr/cvaa310

PMCID:: PMC8752355

Abstract Article PDF–941K

Select item 84463388.

ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1

Wesley Wang, Dolena Ledee

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073

PMCID:: PMC8446338

Abstract Article PDF–830K

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 798599910.

Piperazine ferulate attenuates high glucose-induced mesangial cell injury via the regulation of p66^Shc

Yong-Yu Yang, Rong-Rong Deng, Zhuo Chen, Liang-Yuan Yao, Xi-Ding Yang, Da-Xiong Xiang

Mol Med Rep. 2021 May; 23(5): 374. Published online 2021 Mar 16. doi: 10.3892/mmr.2021.12013

PMCID:: PMC7985999

Abstract Article PDF–8.8M

Select item 776259811.

Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy

Christine Hirschhäuser, Akylbek Sydykov, Annemarie Wolf, Azadeh Esfandiary, Julia Bornbaum, Hanna Sarah Kutsche, Kerstin Boengler, Natascha Sommer, Rolf Schreckenberg, Klaus-Dieter Schlüter, Norbert Weissmann, Ralph Schermuly, Rainer Schulz

Int J Mol Sci. 2020 Dec; 21(24): 9339. Published online 2020 Dec 8. doi: 10.3390/ijms21249339

PMCID:: PMC7762598

Abstract Article PDF–1.0M

Select item 748280212.

circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion

Dongcheng Feng, Zhecheng Wang, Yan Zhao, Yang Li, Deshun Liu, Zhao Chen, Shili Ning, Yan Hu, Jihong Yao, Xiaofeng Tian

Theranostics. 2020; 10(23): 10680–10696. Published online 2020 Aug 29. doi: 10.7150/thno.44250

PMCID:: PMC7482802

Abstract Article PDF–3.0M

Select item 741599113.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 739711414.

The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation

Alex Kiepas, Elena Voorand, Julien Senecal, Ryuhjin Ahn, Matthew G. Annis, Kévin Jacquet, George Tali, Nicolas Bisson, Josie Ursini-Siegel, Peter M. Siegel, Claire M. Brown

J Biol Chem. 2020 Jul 31; 295(31): 10535–10559. Published online 2020 Apr 16. doi: 10.1074/jbc.RA119.011903

PMCID:: PMC7397114

Abstract Article PDF–7.1M

Select item 718429215.

Diurnal oscillations of endogenous H₂O₂ sustained by p66^Shc regulate circadian clocks

Jian-Fei Pei, Xun-Kai Li, Wen-Qi Li, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S. Carroll, Jing Yang, Eric Erquan Zhang, Ji-Min Cao, Hou-Zao Chen, De-Pei Liu

Nat Cell Biol. Author manuscript; available in PMC 2020 Apr 27.

Published in final edited form as: Nat Cell Biol. 2019 Dec; 21(12): 1553–1564. Published online 2019 Nov 25. doi: 10.1038/s41556-019-0420-4

PMCID:: PMC7184292

Abstract Article PDF–6.2M

Select item 698477316.

The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II

Anna Onnis, Valentina Cianfanelli, Chiara Cassioli, Dijana Samardzic, Pier Giuseppe Pelicci, Francesco Cecconi, Cosima T Baldari

Autophagy. 2018; 14(12): 2117–2138. Published online 2018 Sep 6. doi: 10.1080/15548627.2018.1505153

PMCID:: PMC6984773

Abstract Article PDF–4.9M

Select item 688643017.

p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

Laura Patrussi, Nagaja Capitani, Cristina Ulivieri, Noemi Manganaro, Massimo Granai, Francesca Cattaneo, Anna Kabanova, Lucia Mundo, Stefania Gobessi, Federica Frezzato, Andrea Visentin, Francesca Finetti, Pier Giuseppe Pelicci, Mario M. D’Elios, Livio Trentin, Gianpietro Semenzato, Lorenzo Leoncini, Dimitar G. Efremov, Cosima T. Baldari

Haematologica. 2019 Oct; 104(10): 2040–2052. Prepublished online 2019 Feb 28. doi: 10.3324/haematol.2018.209981

PMCID:: PMC6886430

Abstract Article PDF–5.8M

Select item 672594218.

Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC/N-Shc via Interaction with the NMDA Receptor

Yoshiaki Miyamoto, Ling Chen, Masahiro Sato, Masahiro Sokabe, Toshitaka Nabeshima, Tony Pawson, Ryuichi Sakai, Nozomu Mori

J Neurosci. 2005 Feb 16; 25(7): 1826–1835. doi: 10.1523/JNEUROSCI.3030-04.2005

PMCID:: PMC6725942

Abstract Article PDF–469K

Select item 667422319.

Neural-Specific Inactivation of ShcA Results in Increased Embryonic Neural Progenitor Apoptosis and Microencephaly

Karen N. McFarland, Steven R. Wilkes, Sarah E. Koss, Kodi S. Ravichandran, James W. Mandell

J Neurosci. 2006 Jul 26; 26(30): 7885–7897. doi: 10.1523/JNEUROSCI.3524-05.2006

PMCID:: PMC6674223

Abstract Article PDF–886K

Select item 654781020.

Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor

Emma Persson, Pedro P. C. Souza, Thais Floriano-Marcelino, Howard Herschel Conaway, Petra Henning, Ulf H. Lerner

Front Immunol. 2019; 10: 1164. Published online 2019 May 28. doi: 10.3389/fimmu.2019.01164

PMCID:: PMC6547810

Abstract Article PDF–4.5M

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