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Select item 101419431.

IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway

Lei Chen, Xiangrong Li, Yingying Deng, Yingjie Bi, Zhenfang Yan, Yanmei Yang, Xiangbo Zhang, Huixia Li, Jingying Xie, Ruofei Feng

Viruses. 2023 Apr; 15(4): 866. Published online 2023 Mar 28. doi: 10.3390/v15040866

PMCID:: PMC10141943

Abstract Article PDF–5.1M

Select item 91756282.

SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells

Rayhane Nchioua, Annika Schundner, Dorota Kmiec, Caterina Prelli Bozzo, Fabian Zech, Lennart Koepke, Alexander Graf, Stefan Krebs, Helmut Blum, Manfred Frick, Konstantin M. J. Sparrer, Frank Kirchhoff

J Virol. 2022 Jun; 96(11): e00594-22. Published online 2022 May 11. doi: 10.1128/jvi.00594-22

PMCID:: PMC9175628

Abstract Article PDF–4.2M

Select item 89515563.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 86894604.

Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi’s Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner

Bojan F. Hörnich, Anna K. Großkopf, Candice J. Dcosta, Sarah Schlagowski, Alexander S. Hahn

mBio. 2021 Nov-Dec; 12(6): e02113-21. Published online 2021 Dec 21. doi: 10.1128/mBio.02113-21

PMCID:: PMC8689460

Abstract Article PDF–3.7M

Select item 85118565.

Lessons in self-defence: inhibition of virus entry by intrinsic immunity

Saliha Majdoul, Alex A. Compton

Nat Rev Immunol. 2022; 22(6): 339–352. Published online 2021 Oct 13. doi: 10.1038/s41577-021-00626-8

PMCID:: PMC8511856

Abstract Article PDF–3.2M

Select item 84755246.

IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B. Tessema, Andrew G. Brooks, Patrick C. Reading, Sarah L. Londrigan

J Virol. 2021 Oct; 95(20): e00837-21. Prepublished online 2021 Jul 28. Published online 2021 Sep 27. doi: 10.1128/JVI.00837-21

PMCID:: PMC8475524

Abstract Article PDF–3.5M

Select item 83192097.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, Frank Kirchhoff

Nat Commun. 2021; 12: 4584. Published online 2021 Jul 28. doi: 10.1038/s41467-021-24817-y

PMCID:: PMC8319209

Abstract Article PDF–5.0M

Select item 81041178.

The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

Helena Winstone, Maria Jose Lista, Alisha C. Reid, Clement Bouton, Suzanne Pickering, Rui Pedro Galao, Claire Kerridge, Katie J. Doores, Chad M. Swanson, Stuart J. D. Neil

J Virol. 2021 May; 95(9): e02422-20. Prepublished online 2021 Feb 9. Published online 2021 Apr 12. doi: 10.1128/JVI.02422-20

PMCID:: PMC8104117

Abstract Article PDF–2.6M

Select item 77448659.

Opposing activities of IFITM proteins in SARS‐CoV‐2 infection

Guoli Shi, Adam D Kenney, Elena Kudryashova, Ashley Zani, Lizhi Zhang, Kin Kui Lai, Luanne Hall‐Stoodley, Richard T Robinson, Dmitri S Kudryashov, Alex A Compton, Jacob S Yount

EMBO J. 2021 Feb 1; 40(3): e106501. Published online 2020 Dec 21. doi: 10.15252/embj.2020106501

PMCID:: PMC7744865

Abstract Article PDF–2.2M

Select item 756688110.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 732206711.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 711071213.

Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins

Nopporn Chutiwitoonchai, Masateru Hiyoshi, Yuka Hiyoshi-Yoshidomi, Michihiro Hashimoto, Kenzo Tokunaga, Shinya Suzu

Microbes Infect. 2013 Apr; 15(4): 280–290. Published online 2013 Jan 30. doi: 10.1016/j.micinf.2012.12.003

PMCID:: PMC7110712

Abstract Article PDF–1.1M

Select item 710493614.

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

Alex A. Compton, Timothée Bruel, Françoise Porrot, Adeline Mallet, Martin Sachse, Marine Euvrard, Chen Liang, Nicoletta Casartelli, Olivier Schwartz

Cell Host Microbe. 2014 Dec 10; 16(6): 736–747. Published online 2014 Nov 26. doi: 10.1016/j.chom.2014.11.001

PMCID:: PMC7104936

Abstract Article PDF–2.1M

Select item 710278315.

Coordinated regulation of IFITM1, 2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions

Ping Li, Ming-Lei Shi, Wen-Long Shen, Zhang Zhang, De-Jian Xie, Xiang-Yuan Zhang, Chao He, Yan Zhang, Zhi-Hu Zhao

Biochim Biophys Acta Gene Regul Mech. 2017 Aug; 1860(8): 885–893. Published online 2017 May 13. doi: 10.1016/j.bbagrm.2017.05.003

PMCID:: PMC7102783

Abstract Article PDF–1.5M

Select item 707800116.

The IFITM protein family in adaptive immunity

Diana C. Yánez, Susan Ross, Tessa Crompton

Immunology. 2020 Apr; 159(4): 365–372. Published online 2019 Dec 22. doi: 10.1111/imm.13163

PMCID:: PMC7078001

Abstract Article PDF–1.6M

Select item 693755517.

Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins

Ashley Zani, Lizhi Zhang, Temet M. McMichael, Adam D. Kenney, Mahesh Chemudupati, Jesse J. Kwiek, Shan-Lu Liu, Jacob S. Yount

J Biol Chem. 2019 Dec 27; 294(52): 19844–19851. Published online 2019 Nov 17. doi: 10.1074/jbc.AC119.010611

PMCID:: PMC6937555

Abstract Article PDF–1.7M

Select item 616228518.

IFITM proteins inhibit HIV-1 protein synthesis

Wing-Yiu Jason Lee, Rebecca Menhua Fu, Chen Liang, Richard D. Sloan

Sci Rep. 2018; 8: 14551. Published online 2018 Sep 28. doi: 10.1038/s41598-018-32785-5

PMCID:: PMC6162285

Abstract Article PDF–4.6M

Select item 611583919.

The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage

Jingyou Yu, Shan-Lu Liu

Viruses. 2018 Aug; 10(8): 413. Published online 2018 Aug 7. doi: 10.3390/v10080413

PMCID:: PMC6115839

Abstract Article PDF–1.7M

Select item 550259220.

Δ20 IFITM2 differentially restricts X4 and R5 HIV-1

Wan-Lin Wu, Christopher Robert Grotefend, Ming-Ting Tsai, Yi-Ling Wang, Vladimir Radic, Hyungjin Eoh, I-Chueh Huang

Proc Natl Acad Sci U S A. 2017 Jul 3; 114(27): 7112–7117. Published online 2017 Jun 19. doi: 10.1073/pnas.1619640114

PMCID:: PMC5502592

Abstract Article PDF–1.3M

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