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Select item 110289201.

Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients

Ray Wilkinson, Katherine Woods, Rachael D’Rozario, Rebecca Prue, Frank Vari, Melinda Y. Hardy, Ying Dong, Judith A. Clements, Derek N. J. Hart, Kristen J. Radford

Cancer Immunol Immunother. 2012 Feb; 61(2): 169–179. Published online 2011 Aug 27. doi: 10.1007/s00262-011-1095-2

PMCID:: PMC11028920

Abstract Article PDF–597K

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 66886623.

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

Blake T. Riley, David E. Hoke, Sheena McGowan, Ashley M. Buckle

Acta Crystallogr F Struct Biol Commun. 2019 Aug 1; 75(Pt 8): 543–546. Published online 2019 Jul 16. doi: 10.1107/S2053230X19009610

PMCID:: PMC6688662

Abstract Article PDF–575K

Select item 66860154.

A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases

Daisuke Nishimiya, Yoshirou Kawaguchi, Shiho Kodama, Hatsumi Nasu, Hidenori Yano, Aya Yamaguchi, Masakazu Tamura, Ryuji Hashimoto

Sci Rep. 2019; 9: 11436. Published online 2019 Aug 7. doi: 10.1038/s41598-019-47615-5

PMCID:: PMC6686015

Abstract Article PDF–1.3M

Select item 63922725.

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

Weiwei Gong, Yueyang Liu, Christof Seidl, Tobias Dreyer, Enken Drecoll, Matthias Kotzsch, Holger Bronger, Julia Dorn, Viktor Magdolen

PLoS One. 2019; 14(2): e0212968. Published online 2019 Feb 27. doi: 10.1371/journal.pone.0212968

PMCID:: PMC6392272

Abstract Article PDF–991K

Select item 63332826.

Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes

Mi Li, Jaroslav Srp, Alla Gustchina, Zbigniew Dauter, Michael Mares, Alexander Wlodawer

Acta Crystallogr D Struct Biol. 2019 Jan 1; 75(Pt 1): 56–69. Published online 2019 Jan 7. doi: 10.1107/S2059798318016492

PMCID:: PMC6333282

Abstract Article PDF–3.3M

Select item 60646247.

Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression

Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao, Chuanchun Han

J Exp Clin Cancer Res. 2018; 37: 176. Published online 2018 Jul 28. doi: 10.1186/s13046-018-0842-z

Correction in:: J Exp Clin Cancer Res. 2021; 40: 385.

PMCID:: PMC6064624

Abstract Article PDF–5.7M

Select item 56238158.

Thomas Kryza, Lakmali M. Silva, Nathalie Bock, Ruth A. Fuhrman‐Luck, Carson R. Stephens, Jin Gao, Hema Samaratunga, Australian Prostate Cancer BioResource, Mitchell G. Lawrence, John D. Hooper, Ying Dong, Gail P. Risbridger, Judith A. Clements

Mol Oncol. 2017 Oct; 11(10): 1307–1329. Published online 2017 Aug 10. doi: 10.1002/1878-0261.12075

PMCID:: PMC5623815

Abstract Article PDF–1.2M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522510.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 507335411.

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

Blake T. Riley, Olga Ilyichova, Mauricio G. S. Costa, Benjamin T. Porebski, Simon J. de Veer, Joakim E. Swedberg, Itamar Kass, Jonathan M. Harris, David E. Hoke, Ashley M. Buckle

Sci Rep. 2016; 6: 35385. Published online 2016 Oct 21. doi: 10.1038/srep35385

PMCID:: PMC5073354

Abstract Article PDF–2.5M

Select item 487583712.

Maturation Stage Enamel Malformations in Amtn and Klk4 Null Mice

Stephanie M. Nunez, Yong-Hee P. Chun, Bernhard Ganss, Yuanyuan Hu, Amelia S Richardson, James E. Schmitz, Roberto Fajardo, Jie Yang, Jan C-C. Hu, James P. Simmer

Matrix Biol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Matrix Biol. 2016 May-Jul; 52-54: 219–233. Published online 2015 Nov 24. doi: 10.1016/j.matbio.2015.11.007

PMCID:: PMC4875837

Abstract Article PDF–5.3M

Select item 464794113.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721114.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 457723215.

Clinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer

PETROS PAPAGERAKIS, GIUSEPPE PANNONE, LI ZHENG, MARIA ATHANASSIOU-PAPAEFTHYMIOU, YASHUO YAMAKOSHI, HOWARD STAN McGUFF, OMAR SHKEIR, KONSTANTINOS GHIRTIS, SILVANA PAPAGERAKIS

Anticancer Res. Author manuscript; available in PMC 2015 Sep 21.

Published in final edited form as: Anticancer Res. 2015 Apr; 35(4): 1861–1866.

PMCID:: PMC4577232

Abstract Article PDF–786K

Select item 426658816.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 373228617.

A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease

Malin Östensson, Caroline Montén, Jonas Bacelis, Audur H. Gudjonsdottir, Svetlana Adamovic, Johan Ek, Henry Ascher, Elisabet Pollak, Henrik Arnell, Lars Browaldh, Daniel Agardh, Jan Wahlström, Staffan Nilsson, Åsa Torinsson-Naluai

PLoS One. 2013; 8(8): e70174. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0070174

PMCID:: PMC3732286

Abstract Article PDF–1.7M

Select item 373200918.

Susceptibility Loci Associated with Prostate Cancer Progression and Mortality

David J. Gallagher, Joseph Vijai, Angel M. Cronin, Jasmine Bhatia, Andrew J. Vickers, Mia M. Gaudet, Samson Fine, Victor Reuter, Howard I. Scher, Christer Halldén, Ana Dutra-Clarke, Robert J. Klein, Peter T. Scardino, James A. Eastham, Hans Lilja, Tomas Kirchhoff, Kenneth Offit

Clin Cancer Res. Author manuscript; available in PMC 2013 Aug 2.

Published in final edited form as: Clin Cancer Res. 2010 May 15; 16(10): 2819–2832. Published online 2010 May 11. doi: 10.1158/1078-0432.CCR-10-0028

PMCID:: PMC3732009

Abstract Article PDF–683K

Select item 371088519.

Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer

Yang Jin, Su Qu, Martina Tesikova, Ling Wang, Alexandr Kristian, Gunhild M. Mælandsmo, Haiying Kong, Tianzhou Zhang, Carmen Jerónimo, Manuel R. Teixeira, Erkan Yuca, Ibrahim Tekedereli, Kivanc Gorgulu, Neslihan Alpay, Anil K. Sood, Gabriel Lopez-Berestein, Håvard E. Danielsen, Bulent Ozpolat, Fahri Saatcioglu

Proc Natl Acad Sci U S A. 2013 Jul 9; 110(28): E2572–E2581. Published online 2013 Jun 24. doi: 10.1073/pnas.1304318110

PMCID:: PMC3710885

Abstract Article PDF–1.3M

Select item 357699820.

Novel KLK4 and MMP20 Mutations Discovered by Whole-exome Sequencing

S.-K. Wang, Y. Hu, J.P. Simmer, F. Seymen, N.M.R.P. Estrella, S. Pal, B.M. Reid, M. Yildirim, M. Bayram, J.D. Bartlett, J.C.-C. Hu

J Dent Res. 2013 Mar; 92(3): 266–271. doi: 10.1177/0022034513475626

PMCID:: PMC3576998

Abstract Article PDF–496K

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