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Select item 112709111.

Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry

Simon Ducharme, Yolande Pijnenburg, Jonathan D. Rohrer, Edward Huey, Elizabeth Finger, Nadine Tatton

Am J Geriatr Psychiatry. Author manuscript; available in PMC 2024 Jul 25.

Published in final edited form as: Am J Geriatr Psychiatry. 2024 Jan; 32(1): 98–113. Published online 2023 Sep 3. doi: 10.1016/j.jagp.2023.08.017

PMCID:: PMC11270911

Abstract Article PDF–889K

Select item 111869232.

Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies

John L. Robinson, EunRan Suh, Yan Xu, Howard I. Hurtig, Lauren Elman, Corey T. McMillan, David J. Irwin, Sílvia Porta, Vivianna M. Van Deerlin, Edward B. Lee

Acta Neuropathol. 2024; 147(1): 104. Published online 2024 Jun 19. doi: 10.1007/s00401-024-02753-7

PMCID:: PMC11186923

Abstract Article PDF–2.6M

Select item 111868853.

Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database

Davis C. Woodworth, Katelynn M. Nguyen, Lorena Sordo, Kiana A. Scambray, Elizabeth Head, Claudia H. Kawas, María M. Corrada, Peter T. Nelson, S. Ahmad Sajjadi

Acta Neuropathol. 2024; 147(1): 103. Published online 2024 Jun 19. doi: 10.1007/s00401-024-02728-8

PMCID:: PMC11186885

Abstract Article PDF–3.6M

Select item 111726674.

Expression of Wild-Type and Mutant Human TDP-43 in Yeast Inhibits TOROID (TORC1 Organized in Inhibited Domain) Formation and Autophagy Proportionally to the Levels of TDP-43 Toxicity

Sangeun Park, Sei-Kyoung Park, Susan W. Liebman

Int J Mol Sci. 2024 Jun; 25(11): 6258. Published online 2024 Jun 6. doi: 10.3390/ijms25116258

PMCID:: PMC11172667

Abstract Article PDF–2.1M

Select item 111637245.

Elevated nuclear TDP-43 induces constitutive exon skipping

Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling

Mol Neurodegener. 2024; 19: 45. Published online 2024 Jun 9. doi: 10.1186/s13024-024-00732-w

PMCID:: PMC11163724

Abstract Article PDF–8.3M

Select item 111589776.

Interaction of antiproliferative protein Tob with the CCR4‐NOT deadenylase complex

Takashi Miyasaka, Masahiro Morita, Kentaro Ito, Toru Suzuki, Hiroyuki Fukuda, Shizu Takeda, Jun‐Ichiro Inoue, Kentaro Semba, Tadashi Yamamoto

Cancer Sci. 2008 Apr; 99(4): 755–761. Published online 2008 Mar 28. doi: 10.1111/j.1349-7006.2008.00746.x

PMCID:: PMC11158977

Abstract Article PDF–210K

Select item 111550297.

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra, Muralidhar L. Hegde

Mol Brain. 2024; 17: 32. Published online 2024 Jun 5. doi: 10.1186/s13041-024-01108-3

PMCID:: PMC11155029

Abstract Article PDF–1.7M

Select item 111464348.

Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models

Cristian A Droppelmann, Danae Campos-Melo, Veronica Noches, Crystal McLellan, Robert Szabla, Taylor A Lyons, Hind Amzil, Benjamin Withers, Brianna Kaplanis, Kirti S Sonkar, Anne Simon, Emanuele Buratti, Murray Junop, Jamie M Kramer, Michael J Strong

Brain. 2024 Jun; 147(6): 2053–2068. Published online 2024 May 13. doi: 10.1093/brain/awae078

PMCID:: PMC11146434

Abstract Article PDF–1.5M

Select item 111099829.

RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo

Natalie M Scherer, Cindy Maurel, Matthew S Graus, Luke McAlary, Grant Richter, Rowan A W Radford, Alison Hogan, Emily K Don, Albert Lee, Justin Yerbury, Mathias Francois, Roger S Chung, Marco Morsch

Nucleic Acids Res. 2024 May 22; 52(9): 5301–5319. Published online 2024 Feb 21. doi: 10.1093/nar/gkae112

PMCID:: PMC11109982

Abstract Article PDF–3.9M

Select item 1108796710.

Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1

Edward Pokrishevsky, Michéle G. DuVal, Luke McAlary, Sarah Louadi, Silvia Pozzi, Andrei Roman, Steven S. Plotkin, Anke Dijkstra, Jean-Pierre Julien, W. Ted Allison, Neil R. Cashman

J Biol Chem. 2024 May; 300(5): 107207. Published online 2024 Mar 22. doi: 10.1016/j.jbc.2024.107207

PMCID:: PMC11087967

Abstract Article PDF–3.8M

Select item 1106811511.

The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

Julia Zibold, Lola E R Lessard, Flavien Picard, Lara Gruijs da Silva, Yelyzaveta Zadorozhna, Nathalie Streichenberger, Edwige Belotti, Alexis Osseni, Andréa Emerit, Elisabeth Errazuriz-Cerda, Laurence Michel-Calemard, Rita Menassa, Laurent Coudert, Manuela Wiessner, Rolf Stucka, Thomas Klopstock, Francesca Simonetti, Saskia Hutten, Takashi Nonaka, Masato Hasegawa, Tim M Strom, Emilien Bernard, Elisabeth Ollagnon, Andoni Urtizberea, Dorothee Dormann, Philippe Petiot, Laurent Schaeffer, Jan Senderek, Pascal Leblanc

Brain. 2024 May; 147(5): 1768–1783. Published online 2023 Dec 11. doi: 10.1093/brain/awad410

PMCID:: PMC11068115

Abstract Article PDF–1.3M

Select item 1102946612.

Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS

Riley H Lochner, Anithachristy S Arumanayagam, Suzanne Z Powell, Joseph C Masdeu, Belen Pascual, Matthew D Cykowski

J Neuropathol Exp Neurol. 2024 May; 83(5): 307–317. Published online 2024 Apr 9. doi: 10.1093/jnen/nlae027

PMCID:: PMC11029466

Abstract Article PDF–6.0M

Select item 1100705313.

Distribution of ubiquilin 2 and TDP‐43 aggregates throughout the CNS in UBQLN2 p.T487I‐linked amyotrophic lateral sclerosis and frontotemporal dementia

Laura R. Nementzik, Kyrah M. Thumbadoo, Helen C. Murray, David Gordon, Shu Yang, Ian P. Blair, Clinton Turner, Richard L. M. Faull, Maurice A. Curtis, Catriona McLean, Garth A. Nicholson, Molly E. V. Swanson, Emma L. Scotter

Brain Pathol. 2024 May; 34(3): e13230. Published online 2023 Dec 19. doi: 10.1111/bpa.13230

PMCID:: PMC11007053

Abstract Article PDF–3.6M

Select item 1098956414.

A novel long non‐coding RNALINC00524 facilitates invasion and metastasis through interaction with TDP43 in breast cancer

Xianglin Sun, Wenfeng Li, Gang Li, Huan Yang, Zhenglin Jiang, Lihua Shen, Yuexiang Shen, Yifei Liu, Guohua Wang

J Cell Mol Med. 2024 Apr; 28(8): e18275. Published online 2024 Apr 3. doi: 10.1111/jcmm.18275

PMCID:: PMC10989564

Abstract Article PDF–17M

Select item 1098821815.

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43

Juan M. Godoy-Corchuelo, Zeinab Ali, Jose M. Brito Armas, Aurea B. Martins-Bach, Irene García-Toledo, Luis C. Fernández-Beltrán, Juan I. López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A. Muñoz de Bustillo Alfaro, Maria J. Sánchez-Barrena, Remya R. Nair, Brian J. Nieman, Jason P. Lerch, Karla L. Miller, Hande P. Ozdinler, Elizabeth M.C. Fisher, Thomas J. Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano

Neurobiol Dis. 2024 Apr; 193: 106437. doi: 10.1016/j.nbd.2024.106437

PMCID:: PMC10988218

Abstract Article PDF–13M

Select item 1096291316.

Cognitive and Behavioral Features of Patients With Amyotrophic Lateral Sclerosis Who Are Carriers of the TARDBP Pathogenic Variant

Cristina Moglia, Andrea Calvo, Antonio Canosa, Umberto Manera, Rosario Vasta, Francesca Di Pede, Margherita Daviddi, Enrico Matteoni, Maura Brunetti, Luca Sbaiz, Sara Cabras, Salvatore Gallone, Maurizio Grassano, Laura Peotta, Francesca Palumbo, Gabriele Mora, Barbara Iazzolino, Adriano Chio

Neurology. 2024 Feb 27; 102(4): e208082. Published online 2024 Jan 23. doi: 10.1212/WNL.0000000000208082

PMCID:: PMC10962913

Abstract Article PDF–307K

Select item 1093151817.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention

Patricia M. dos Passos, Erandika H. Hemamali, Lohany D. Mamede, Lindsey R. Hayes, Yuna M. Ayala

PLoS Biol. 2024 Feb; 22(2): e3002527. Published online 2024 Feb 29. doi: 10.1371/journal.pbio.3002527

PMCID:: PMC10931518

Abstract Article PDF–2.8M

Select item 1092600118.

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

Amanda J. Guise, Santosh A. Misal, Richard Carson, Jen-Hwa Chu, Hannah Boekweg, Daisha Van Der Watt, Nora C. Welsh, Thy Truong, Yiran Liang, Shanqin Xu, Gina Benedetto, Jake Gagnon, Samuel H. Payne, Edward D. Plowey, Ryan T. Kelly

Cell Rep. Author manuscript; available in PMC 2024 Mar 11.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113636. Published online 2024 Jan 5. doi: 10.1016/j.celrep.2023.113636

PMCID:: PMC10926001

Abstract Article PDF–2.3M

Select item 1091236319.

RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation

Clément Demongin, Samuel Tranier, Vandana Joshi, Léa Ceschi, Bénédicte Desforges, David Pastré, Loic Hamon

J Biol Chem. 2024 Mar; 300(3): 105716. Published online 2024 Feb 2. doi: 10.1016/j.jbc.2024.105716

PMCID:: PMC10912363

Abstract Article PDF–5.8M

Select item 1090162120.

Colocalization of TDP‐43 and stress granules at the early stage of TDP‐43 aggregation in amyotrophic lateral sclerosis

Fumiaki Mori, Hina Yasui, Yasuo Miki, Tomoya Kon, Akira Arai, Hidekachi Kurotaki, Masahiko Tomiyama, Koichi Wakabayashi

Brain Pathol. 2024 Mar; 34(2): e13215. Published online 2023 Oct 4. doi: 10.1111/bpa.13215

PMCID:: PMC10901621

Abstract Article PDF–8.8M

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