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Select item 93485761.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 87690722.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 85054703.

What are the roles of global DNA and APC 2 gene promotor hypermethylation in multiple myeloma?

Sacide Pehlivan, Istemi Serin, Ayse Feyda Nursal, Yasemin Oyaci, Ilknur Gundes, Mustafa Pehlivan

Mol Biol Rep. 2021; 48(12): 7875–7882. Published online 2021 Oct 12. doi: 10.1007/s11033-021-06813-z

PMCID:: PMC8505470

Abstract Article PDF–579K

Select item 82175134.

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N⁶-methyladenosine-dependent YTHDF binding

Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu

Nat Commun. 2021; 12: 3803. Published online 2021 Jun 21. doi: 10.1038/s41467-021-23501-5

Correction in:: Nat Commun. 2021; 12: 4529.

PMCID:: PMC8217513

Abstract Article PDF–5.2M

Select item 68175485.

Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay

Sangmoon Lee, Dillon Y. Chen, Maha S. Zaki, Reza Maroofian, Henry Houlden, Nataliya Di Donato, Dalia Abdin, Heba Morsy, Ghayda M. Mirzaa, William B. Dobyns, Jennifer McEvoy-Venneri, Valentina Stanley, Kiely N. James, Grazia M.S. Mancini, Rachel Schot, Tugba Kalayci, Umut Altunoglu, Ehsan Ghayoor Karimiani, Lauren Brick, Mariya Kozenko, Yalda Jamshidi, M. Chiara Manzini, Mehran Beiraghi Toosi, Joseph G. Gleeson

Am J Hum Genet. 2019 Oct 3; 105(4): 844–853. Published online 2019 Oct 3. doi: 10.1016/j.ajhg.2019.08.013

PMCID:: PMC6817548

Abstract Article PDF–1.7M

Select item 67781376.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 62313837.

Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer

Yuan He, Li-Yue Sun, Jing Wang, Rui Gong, Qiong Shao, Zi-Chen Zhang, Zu-Lu Ye, Hai-Yun Wang, Rui-Hua Xu, Jian-Yong Shao

Dis Markers. 2018; 2018: 8619462. Published online 2018 Oct 29. doi: 10.1155/2018/8619462

PMCID:: PMC6231383

Abstract Article PDF–2.1M

Select item 60502788.

APC2 controls dendrite development by promoting microtubule dynamics

Olga I. Kahn, Philipp Schätzle, Dieudonnée van de Willige, Roderick P. Tas, Feline W. Lindhout, Sybren Portegies, Lukas C. Kapitein, Casper C. Hoogenraad

Nat Commun. 2018; 9: 2773. Published online 2018 Jul 17. doi: 10.1038/s41467-018-05124-5

PMCID:: PMC6050278

Abstract Article PDF–7.9M

Select item 58846739.

Sumoylation promotes optimal APC/C activation and timely anaphase

Christine C Lee, Bing Li, Hongtao Yu, Michael J Matunis

eLife. 2018; 7: e29539. Published online 2018 Mar 8. doi: 10.7554/eLife.29539

PMCID:: PMC5884673

Abstract Article PDF–5.8M

Select item 582692610.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 521993311.

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium

C S Daly, P Shaw, L D Ordonez, G T Williams, J Quist, A Grigoriadis, J H Van Es, H Clevers, A R Clarke, K R Reed

Oncogene. 2017; 36(13): 1793–1803. Published online 2016 Oct 3. doi: 10.1038/onc.2016.342

Correction in:: Oncogene. 2024; 43(12): 918.

PMCID:: PMC5219933

Abstract Article PDF–6.7M

Select item 493344712.

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2

Heather E. Croy, Caitlyn N. Fuller, Jemma Giannotti, Paige Robinson, Andrew V. A. Foley, Robert J. Yamulla, Sean Cosgriff, Bradford D. Greaves, Ryan A. von Kleeck, Hyun Hyung An, Catherine M. Powers, Julie K. Tran, Aaron M. Tocker, Kimberly D. Jacob, Beckley K. Davis, David M. Roberts

J Biol Chem. 2016 Jun 10; 291(24): 12747–12760. Published online 2016 Apr 11. doi: 10.1074/jbc.M115.705442

PMCID:: PMC4933447

Abstract Article PDF–4.4M

Select item 456844513.

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

Mira I Pronobis, Nasser M Rusan, Mark Peifer

eLife. 2015; 4: e08022. Published online 2015 Sep 22. doi: 10.7554/eLife.08022

PMCID:: PMC4568445

Abstract Article PDF–8.9M

Select item 436785714.

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing

Fernanda Luisa Basei, Gabriela Vaz Meirelles, Germanna Lima Righetto, Deivid Lucas dos Santos Migueleti, Juliana Helena Costa Smetana, Jörg Kobarg

Proteome Sci. 2015; 13: 11. Published online 2015 Feb 26. doi: 10.1186/s12953-015-0065-6

PMCID:: PMC4367857

Abstract Article PDF–3.1M

Select item 369817715.

Functional Comparison of Human Adenomatous Polyposis Coli (APC) and APC-Like in Targeting Beta-Catenin for Degradation

Jean Schneikert, Shree Harsha Vijaya Chandra, Jan Gustav Ruppert, Suparna Ray, Eva Maria Wenzel, Jürgen Behrens

PLoS One. 2013; 8(7): e68072. Published online 2013 Jul 1. doi: 10.1371/journal.pone.0068072

PMCID:: PMC3698177

Abstract Article PDF–4.7M

Select item 336417016.

Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization

David M. Roberts, Mira I. Pronobis, John S. Poulton, Eric G. Kane, Mark Peifer

Mol Biol Cell. 2012 Jun 1; 23(11): 2041–2056. doi: 10.1091/mbc.E11-11-0965

PMCID:: PMC3364170

Abstract Article PDF–7.9M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316943218.

Protein interactome reveals converging molecular pathways among autism disorders

Yasunari Sakai, Chad A. Shaw, Brian C. Dawson, Diana V. Dugas, Zaina Al-Mohtaseb, David E. Hill, Huda Y. Zoghbi

Sci Transl Med. Author manuscript; available in PMC 2011 Dec 8.

Published in final edited form as: Sci Transl Med. 2011 Jun 8; 3(86): 86ra49. doi: 10.1126/scitranslmed.3002166

PMCID:: PMC3169432

Abstract Article PDF–6.0M

Select item 294516819.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583220.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

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