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Select item 112155181.

Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction

Juan Sierra-Marquez, Lena Schaller, Lukas Sassenbach, Antonio Ramírez-Fernández, Philipp Alt, Björn Rissiek, Béla Zimmer, Johann Schredelseker, Julia Hector, Tobias Stähler, Friedrich Koch-Nolte, Claudia A. Staab-Weijnitz, Alexander Dietrich, Robin Kopp, Annette Nicke

Front Immunol. 2024; 15: 1425938. Published online 2024 Jun 17. doi: 10.3389/fimmu.2024.1425938

PMCID:: PMC11215518

Abstract Article PDF–3.8M

Select item 110250162.

Bone marrow plasma cells require P2rX4 to sense extracellular ATP

Masaki Ishikawa, Zainul S. Hasanali, Yongge Zhao, Arundhoti Das, Marieke Lavaert, Carly J. Roman, Jennifer Londregan, David Allman, Avinash Bhandoola

Nature. Author manuscript; available in PMC 2024 Apr 18.

Published in final edited form as: Nature. 2024 Feb; 626(8001): 1102–1107. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07047-2

PMCID:: PMC11025016

Abstract Article PDF–5.5M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109021064.

Time-resolved role of P2X4 and P2X7 during CD8⁺ T cell activation

Valerie J. Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H. Guse, René Werner, Björn-Philipp Diercks

Front Immunol. 2024; 15: 1258119. Published online 2024 Feb 15. doi: 10.3389/fimmu.2024.1258119

PMCID:: PMC10902106

Abstract Article PDF–3.8M

Select item 107945065.

P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder

Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Ramy Adel, Marie Tuifua, Awatef Ali, Amina E. Essawy, Sherine Abdel Salam, Walid Hleihel, Eric Boué-Grabot, Marc Landry

Front Pharmacol. 2023; 14: 1288994. Published online 2024 Jan 4. doi: 10.3389/fphar.2023.1288994

PMCID:: PMC10794506

Abstract Article PDF–3.0M

Select item 105392656.

Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke

Daylin Gamiotea-Turro, Chunxia C Cronin, Bruce T Liang, Rajkumar Verma

Purinergic Signal. 2023 Sep; 19(3): 489–500. Published online 2023 Jul 13. doi: 10.1007/s11302-023-09956-9

PMCID:: PMC10539265

Abstract Article PDF–3.8M

Select item 104716997.

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway

Yuanshui Wu, Xiaoli Huang, Le Yang, Yuanjie Liu

Sci Rep. 2023; 13: 14288. Published online 2023 Aug 31. doi: 10.1038/s41598-023-40748-8

PMCID:: PMC10471699

Abstract Article PDF–3.5M

Select item 101631208.

Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer’s disease

Jennifer Hua, Elvira Garcia de Paco, Nathalie Linck, Tangui Maurice, Catherine Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulmann

Cell Mol Life Sci. 2023 May; 80(5): 138. Published online 2023 May 5. doi: 10.1007/s00018-023-04784-x

PMCID:: PMC10163120

Abstract Article PDF–5.0M

Select item 101220719.

P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis

Peijie Zhong, Hang Wu, Yuanqiao Ma, Xiaoxiao Xu, Yizhuo Jiang, Chaolei Jin, Qiaozhen Zhu, Xinlei Liu, Zhimin Suo, Junpeng Wang

Clin Transl Med. 2023 Apr; 13(4): e1227. Published online 2023 Apr 21. doi: 10.1002/ctm2.1227

PMCID:: PMC10122071

Abstract Article PDF–5.7M

Select item 973910610.

Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy

Natalia Martínez-Gil, Oksana Kutsyr, Agustina Noailles, Laura Fernández-Sánchez, Lorena Vidal, Xavier Sánchez-Sáez, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca, Antonio G. García, Victoria Maneu

Int J Mol Sci. 2022 Dec; 23(23): 14758. Published online 2022 Nov 25. doi: 10.3390/ijms232314758

PMCID:: PMC9739106

Abstract Article PDF–22M

Select item 963381611.

P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice

Kazuki Yoshida, Shota Tanihara, Yuki Miyashita, Kosuke Obayashi, Masa-aki Ito, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka

Sci Rep. 2022; 12: 18613. Published online 2022 Nov 3. doi: 10.1038/s41598-022-21667-6

PMCID:: PMC9633816

Abstract Article PDF–1.5M

Select item 935284412.

P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice

Meng-Xi Xu, Guo-Li Zhao, Xin Hu, Han Zhou, Shu-Ying Li, Fang Li, Yanying Miao, Bo Lei, Zhongfeng Wang

Neurosci Bull. 2022 Aug; 38(8): 901–915. Published online 2022 Mar 7. doi: 10.1007/s12264-022-00833-w

PMCID:: PMC9352844

Abstract Article PDF–3.4M

Select item 929643213.

Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice

Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine S. Bertrand, Eric Boué-Grabot

Cell Mol Life Sci. 2022 Aug; 79(8): 431. Published online 2022 Jul 19. doi: 10.1007/s00018-022-04461-5

PMCID:: PMC9296432

Abstract Article PDF–2.7M

Select item 917863214.

干扰肿瘤相关巨噬细胞的P2X4受体表达可抑制胶质瘤细胞的迁移和侵袭

杨学智, 沈红, 李群, 代自超, 杨荣强, 黄国宾, 陈蕊, 王芳, 宋精玲, 华海蓉

Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20; 42(5): 658–664. Chinese. doi: 10.12122/j.issn.1673-4254.2022.05.05

PMCID:: PMC9178632

Abstract Article PDF–2.1M

Select item 917537615.

Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation

Sven Schneider, Irmgard Merfort, Marco Idzko, Andreas Zech

Respir Res. 2022; 23: 148. Published online 2022 Jun 8. doi: 10.1186/s12931-022-02072-z

PMCID:: PMC9175376

Abstract Article PDF–1.2M

Select item 913023216.

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

Natsuko Kondo, Yoshinori Sakurai, Takushi Takata, Kuniyuki Kano, Kyo Kume, Munetoshi Maeda, Nobuhiko Takai, Shugo Suzuki, Fumihiro Eto, Kenji Kikushima, Hideki Wanibuchi, Shin-Ichi Miyatake, Takayuki Kajihara, Shoji Oda, Mitsutoshi Setou, Junken Aoki, Minoru Suzuki

Sci Rep. 2022; 12: 8718. Published online 2022 May 24. doi: 10.1038/s41598-022-12293-3

PMCID:: PMC9130232

Abstract Article PDF–3.5M

Select item 887011117.

Synergistic Cytokine Production by ATP and PGE₂ via P2X4 and EP₃ Receptors in Mouse Bone-Marrow-Derived Mast Cells

Kosuke Obayashi, Kazuki Yoshida, Masa-aki Ito, Tetsuya Mori, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka

Cells. 2022 Feb; 11(4): 616. Published online 2022 Feb 10. doi: 10.3390/cells11040616

PMCID:: PMC8870111

Abstract Article PDF–3.6M

Select item 885723518.

P2X₄ deficiency reduces atherosclerosis and plaque inflammation in mice

Alexander Peikert, Sebastian König, Dymphie Suchanek, Karlos Rofa, Ibrahim Schäfer, Daniel Dimanski, Lorenz Karnbrock, Kseniya Bulatova, Juliane Engelmann, Natalie Hoppe, Carolin Wadle, Timo Heidt, Philipp Albrecht, Sunaina von Garlen, Carmen Härdtner, Ingo Hilgendorf, Dennis Wolf, Constantin von zur Mühlen, Christoph Bode, Andreas Zirlik, Daniel Duerschmied, Julian Merz, Peter Stachon

Sci Rep. 2022; 12: 2801. Published online 2022 Feb 18. doi: 10.1038/s41598-022-06706-6

PMCID:: PMC8857235

Abstract Article PDF–2.9M

Select item 881633519.

P2X4 and P2X7 are essential players in basal T cell activity and Ca²⁺ signaling milliseconds after T cell activation

Valerie J. Brock, Insa M. A. Wolf, Marco Er-Lukowiak, Niels Lory, Tobias Stähler, Lena-Marie Woelk, Hans-Willi Mittrücker, Christa E. Müller, Friedrich Koch-Nolte, Björn Rissiek, René Werner, Andreas H. Guse, Björn-Philipp Diercks

Sci Adv. 2022 Feb; 8(5): eabl9770. Published online 2022 Feb 4. doi: 10.1126/sciadv.abl9770

PMCID:: PMC8816335

Abstract Article PDF–9.5M

Select item 858400220.

Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury

Eun-Jung Sohn, Yun-Kyeong Nam, Hwan-Tae Park

Int J Mol Sci. 2021 Nov; 22(21): 11601. Published online 2021 Oct 27. doi: 10.3390/ijms222111601

PMCID:: PMC8584002

Abstract Article PDF–1.7M

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