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Select item 107028301.

CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection

Hannah M Burgess, Rebecca Grande, Sofia Riccio, Ikshitaa Dinesh, Gerlof Sebastiaan Winkler, Daniel P Depledge, Ian Mohr

EMBO Rep. 2023 Dec; 24(12): e56327. Published online 2023 Oct 17. doi: 10.15252/embr.202256327

PMCID:: PMC10702830

Abstract Article PDF–2.8M

Select item 101276932.

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto

mBio. 2023 Mar-Apr; 14(2): e00196-23. Published online 2023 Apr 5. doi: 10.1128/mbio.00196-23

PMCID:: PMC10127693

Abstract Article PDF–3.8M

Select item 101202093.

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil

J Transl Med. 2023; 21: 271. Published online 2023 Apr 21. doi: 10.1186/s12967-023-04104-8

PMCID:: PMC10120209

Abstract Article PDF–6.8M

Select item 88636634.

FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer

Tania Sarkar, Subhanki Dhar, Dwaipayan Chakraborty, Subhadip Pati, Sayantan Bose, Abir K. Panda, Udit Basak, Sourio Chakraborty, Sumon Mukherjee, Aharna Guin, Kuladip Jana, Diptendra K. Sarkar, Gaurisankar Sa

Front Immunol. 2022; 13: 740588. Published online 2022 Feb 9. doi: 10.3389/fimmu.2022.740588

PMCID:: PMC8863663

Abstract Article PDF–16M

Select item 88547155.

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma

Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang, Xianyue Ren, Tong Wu, Juan Xia, Bin Cheng, Xiaoan Tao

Cell Death Dis. 2022 Feb; 13(2): 158. Published online 2022 Feb 17. doi: 10.1038/s41419-022-04610-5

PMCID:: PMC8854715

Abstract Article PDF–21M

Select item 86608006.

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, Georg Stoecklin

Nat Commun. 2021; 12: 7175. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27471-6

PMCID:: PMC8660800

Abstract Article PDF–5.3M

Select item 82501207.

Upregulation of CCR4 in activated CD8⁺ T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection

Silvia Spoerl, Anita N. Kremer, Michael Aigner, Nina Eisenhauer, Pauline Koch, Lina Meretuk, Patrick Löffler, Matthias Tenbusch, Clara Maier, Klaus Überla, Lucie Heinzerling, Benjamin Frey, Gloria Lutzny‐Geier, Thomas H. Winkler, Gerhard Krönke, Marcel Vetter, Heiko Bruns, Markus F. Neurath, Andreas Mackensen, Andreas E. Kremer, Simon Völkl

Eur J Immunol. 2021 Jun; 51(6): 1436–1448. Published online 2021 Apr 19. doi: 10.1002/eji.202049135

PMCID:: PMC8250120

Abstract Article PDF–1.3M

Select item 79178048.

Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex

Fusako Munakata, Masataka Suzawa, Kumiko Ui-Tei

Genes (Basel) 2021 Feb; 12(2): 271. Published online 2021 Feb 13. doi: 10.3390/genes12020271

PMCID:: PMC7917804

Abstract Article PDF–1.3M

Select item 76929939.

Tumors establish resistance to immunotherapy by regulating T_reg recruitment via CCR4

Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Brian Wong, Dirk G Brockstedt, Oezcan Talay

J Immunother Cancer. 2020; 8(2): e000764. Published online 2020 Nov 26. doi: 10.1136/jitc-2020-000764

PMCID:: PMC7692993

Abstract Article PDF–1.3M

Select item 757756110.

CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment.

Shamir Geller, Travis J. Hollmann, Steven M. Horwitz, Patricia L. Myskowski, Melissa Pulitzer

Histopathology. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Histopathology. 2020 Jan; 76(2): 222–232. Published online 2019 Nov 13. doi: 10.1111/his.13960

PMCID:: PMC7577561

Abstract Article PDF–1.2M

Select item 733264511.

De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay

Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer

Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017

PMCID:: PMC7332645

Abstract Article PDF–1.0M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 715507213.

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation

Caroline A. Anderson, Pallavi Patel, Jonathan M. Viney, Rhian M. Phillips, Roberto Solari, James E. Pease

J Leukoc Biol. 2020 Mar; 107(3): 455–466. Published online 2020 Feb 13. doi: 10.1002/JLB.2A0120-089RR

PMCID:: PMC7155072

Abstract Article PDF–1.5M

Select item 709236114.

Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations

Takashi Kurashige, Tomomi Murao, Naoko Mine, Tomohito Sugiura, Yukiko Inazuka, Kazuya Kuraoka, Tetsuya Takahashi, Hirofumi Maruyama, Tsuyoshi Torii

J Neuropathol Exp Neurol. 2020 Apr; 79(4): 448–457. Published online 2020 Feb 25. doi: 10.1093/jnen/nlaa006

PMCID:: PMC7092361

Abstract Article PDF–1.6M

Select item 688618515.

eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR

Ania Wilczynska, Sarah L. Gillen, Tobias Schmidt, Hedda A. Meijer, Rebekah Jukes-Jones, Claudia Langlais, Kari Kopra, Wei-Ting Lu, Jack D. Godfrey, Benjamin R. Hawley, Kelly Hodge, Sara Zanivan, Kelvin Cain, John Le Quesne, Martin Bushell

Genome Biol. 2019; 20: 262. Published online 2019 Dec 2. doi: 10.1186/s13059-019-1857-2

PMCID:: PMC6886185

Abstract Article PDF–3.2M

Select item 675347316.

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

Chung-Te Chang, Sowndarya Muthukumar, Ramona Weber, Yevgen Levdansky, Ying Chen, Dipankar Bhandari, Catia Igreja, Lara Wohlbold, Eugene Valkov, Elisa Izaurralde

Nucleic Acids Res. 2019 Sep 26; 47(17): 9282–9295. Published online 2019 Jul 24. doi: 10.1093/nar/gkz633

PMCID:: PMC6753473

Abstract Article PDF–2.4M

Select item 571327517.

The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity

Stefanie Scheu, Shafaqat Ali, Christina Ruland, Volker Arolt, Judith Alferink

Int J Mol Sci. 2017 Nov; 18(11): 2306. Published online 2017 Nov 2. doi: 10.3390/ijms18112306

PMCID:: PMC5713275

Abstract Article PDF–260K

Select item 562004618.

Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior

Xi Cheng, Huo Wu, Zhi-Jian Jin, Ding Ma, Stanley Yuen, Xiao-Qian Jing, Min-Min Shi, Bai-Yong Shen, Cheng-Hong Peng, Ren Zhao, Wei-Hua Qiu

Sci Rep. 2017; 7: 12362. Published online 2017 Sep 28. doi: 10.1038/s41598-017-10267-4

PMCID:: PMC5620046

Abstract Article PDF–2.9M

Select item 557550019.

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets

Jeroen K. Buskermolen, Sanne Roffel, Susan Gibbs

J Cell Physiol. 2017 Nov; 232(11): 2996–3005. Published online 2017 May 23. doi: 10.1002/jcp.25946

PMCID:: PMC5575500

Abstract Article PDF–2.1M

Select item 537173020.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

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