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Select item 111005521.

ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2‐mediated inhibition of TREM2

Fan Yang, Muhu Chen, Ying Liu, Yingchun Hu, Yangxi Chen, Youwei Yu, Lu Deng

J Cell Mol Med. 2024 May; 28(10): e18280. Published online 2024 May 17. doi: 10.1111/jcmm.18280

PMCID:: PMC11100552

Abstract Article PDF–22M

Select item 107017692.

ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

Tsuyoshi Kadomatsu, Chiaki Hara, Ryoma Kurahashi, Haruki Horiguchi, Jun Morinaga, Keishi Miyata, Sohtaro Kurano, Hisashi Kanemaru, Satoshi Fukushima, Kimi Araki, Masaya Baba, W. Marston Linehan, Tomomi Kamba, Yuichi Oike

Mol Oncol. 2023 Dec; 17(12): 2637–2658. Published online 2023 Aug 7. doi: 10.1002/1878-0261.13490

PMCID:: PMC10701769

Abstract Article PDF–6.0M

Select item 105171623.

ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis

Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Kazutoyo Terada, Michio Sato, Jun Morinaga, Keishi Miyata, Yuichi Oike

Commun Biol. 2023; 6: 965. Published online 2023 Sep 22. doi: 10.1038/s42003-023-05338-4

PMCID:: PMC10517162

Abstract Article PDF–2.6M

Select item 99743094.

ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway

Xiaoyan Huang, Zegeng Su, Shuncai Zhang, Xiaoling Xu, Bo Yang, Xiang Xu

Mediators Inflamm. 2023; 2023: 2453402. Published online 2023 Feb 21. doi: 10.1155/2023/2453402

PMCID:: PMC9974309

Abstract Article PDF–1.5M

Select item 96818435.

Angiopoietin-like 2 is essential to aortic valve development in mice

Pauline Labbé, Victoria Munoz Goyette, Nathalie Thorin-Trescases, Louis Villeneuve, Ines Desanlis, Constance Delwarde, Yan-Fen Shi, Cécile Martel, Carol Yu, Azadeh Alikashani, Maya Mamarbachi, Frédéric Lesage, Samuel Mathieu, Jean-Claude Tardif, Patrick Mathieu, Marie Kmita, Éric Thorin

Commun Biol. 2022; 5: 1277. Published online 2022 Nov 21. doi: 10.1038/s42003-022-04243-6

PMCID:: PMC9681843

Abstract Article PDF–13M

Select item 90150106.

Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches

Zhuo Yu, Wenqian Yang, Xiaoxiao He, Chiqi Chen, Wenrui Li, Limin Zhao, Ligen Liu, Junling Liu, Li Xie, Yaping Zhang, Junke Zheng

Blood. 2022 Mar 10; 139(10): 1529–1540. doi: 10.1182/blood.2021011644

PMCID:: PMC9015010

Abstract Article

Select item 88048377.

ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes

Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto

Cartilage. 2021 Dec; 13(2 Suppl): 885S–897S. Published online 2019 Oct 4. doi: 10.1177/1947603519878242

PMCID:: PMC8804837

Abstract Article PDF–1.4M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 77734009.

ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression

Dan Huang, Guohuan Sun, Xiaoxin Hao, Xiaoxiao He, Zhaofeng Zheng, Chiqi Chen, Zhuo Yu, Li Xie, Shihui Ma, Ligen Liu, Bo O. Zhou, Hui Cheng, Junke Zheng, Tao Cheng

J Clin Invest. 2021 Jan 4; 131(1): e138986. Published online 2021 Jan 4. doi: 10.1172/JCI138986

PMCID:: PMC7773400

Abstract Article PDF–7.4M

Select item 694204810.

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity

Haruki Horiguchi, Tsuyoshi Kadomatsu, Ryoma Kurahashi, Chiaki Hara, Keishi Miyata, Masaya Baba, Hironobu Osumi, Kazutoyo Terada, Kimi Araki, Toshiyuki Takai, Tomomi Kamba, W. Marston Linehan, Toshiro Moroishi, Yuichi Oike

Genes Dev. 2019 Dec 1; 33(23-24): 1641–1656. doi: 10.1101/gad.329417.119

PMCID:: PMC6942048

Abstract Article PDF–6.5M

Select item 659479311.

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Laurie Caland, Pauline Labbé, Maya Mamarbachi, Louis Villeneuve, Gerardo Ferbeyre, Pierre-Emmanuel Noly, Michel Carrier, Nathalie Thorin-Trescases, Éric Thorin

Aging (Albany NY) 2019 Jun 15; 11(11): 3832–3850. Published online 2019 Jun 11. doi: 10.18632/aging.102020

PMCID:: PMC6594793

Abstract Article PDF–2.0M

Select item 629804012.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 579829213.

Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice

Jiabin Zhao, Zhe Tian, Tsuyoshi Kadomatsu, Peiyu Xie, Keishi Miyata, Taichi Sugizaki, Motoyoshi Endo, Shunshun Zhu, Haoqiu Fan, Haruki Horiguchi, Jun Morinaga, Kazutoyo Terada, Tatsuya Yoshizawa, Kazuya Yamagata, Yuichi Oike

J Biol Chem. 2018 Feb 2; 293(5): 1596–1609. Published online 2017 Nov 30. doi: 10.1074/jbc.M117.814996

PMCID:: PMC5798292

Abstract Article PDF–4.1M

Select item 569495014.

ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis

Haruki Horiguchi, Motoyoshi Endo, Kohki Kawane, Tsuyoshi Kadomatsu, Kazutoyo Terada, Jun Morinaga, Kimi Araki, Keishi Miyata, Yuichi Oike

EMBO J. 2017 Feb 15; 36(4): 409–424. Published online 2017 Jan 2. doi: 10.15252/embj.201695690

PMCID:: PMC5694950

Abstract Article PDF–2.5M

Select item 539593415.

Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions

Lija Swain, Marieke Wottawa, Annette Hillemann, Angelika Beneke, Haruki Odagiri, Kazutoyo Terada, Motoyoshi Endo, Yuichi Oike, Katja Farhat, Dörthe M. Katschinski

J Leukoc Biol. 2014 Sep; 96(3): 365–375. doi: 10.1189/jlb.2HI1013-533R

PMCID:: PMC5395934

Abstract Article

Select item 511571616.

Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion

Toshihiro Amadatsu, Jun Morinaga, Takayuki Kawano, Kazutoyo Terada, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Daiki Kasamo, Jun-ichi Kuratsu, Yuichi Oike

PLoS One. 2016; 11(11): e0166285. Published online 2016 Nov 18. doi: 10.1371/journal.pone.0166285

PMCID:: PMC5115716

Abstract Article PDF–1.8M

Select item 500925717.

Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity

Masaki Yugami, Haruki Odagiri, Motoyoshi Endo, Hiroyasu Tsutsuki, Shigemoto Fujii, Tsuyoshi Kadomatsu, Tetsuro Masuda, Keishi Miyata, Kazutoyo Terada, Hironori Tanoue, Hitoshi Ito, Jun Morinaga, Haruki Horiguchi, Taichi Sugizaki, Takaaki Akaike, Tomomi Gotoh, Toshiyuki Takai, Tomohiro Sawa, Hiroshi Mizuta, Yuichi Oike

J Biol Chem. 2016 Sep 2; 291(36): 18843–18852. Published online 2016 Jul 11. doi: 10.1074/jbc.M116.720870

PMCID:: PMC5009257

Abstract Article PDF–1.7M

Select item 481716918.

Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration

Manabu Hirasawa, Keiyo Takubo, Hideto Osada, Seiji Miyake, Eriko Toda, Motoyoshi Endo, Kazuo Umezawa, Kazuo Tsubota, Yuichi Oike, Yoko Ozawa

J Biol Chem. 2016 Apr 1; 291(14): 7373–7385. Published online 2016 Feb 2. doi: 10.1074/jbc.M115.710186

PMCID:: PMC4817169

Abstract Article PDF–3.6M

Select item 462196119.

Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells

Masato Umikawa, Asako Umikawa, Tsuyoshi Asato, Kimiko Takei, Goro Matsuzaki, Ken-ichi Kariya, Cheng Cheng Zhang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2016 Nov 13.

Published in final edited form as: Biochem Biophys Res Commun. 2015 Nov 13; 467(2): 235–241. Published online 2015 Oct 3. doi: 10.1016/j.bbrc.2015.09.183

PMCID:: PMC4621961

Abstract Article PDF–1.2M

Select item 448919220.

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance

Yusuke Sasaki, Masayuki Ohta, Dhruv Desai, Jose-Luiz Figueiredo, Mary C. Whelan, Tomohiro Sugano, Masaki Yamabi, Wataru Yano, Tyler Faits, Katsumi Yabusaki, Hengmin Zhang, Andrew K. Mlynarchik, Keisuke Inoue, Ken Mizuno, Masanori Aikawa

PLoS One. 2015; 10(7): e0131176. Published online 2015 Jul 1. doi: 10.1371/journal.pone.0131176

PMCID:: PMC4489192

Abstract Article PDF–3.5M

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