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Select item 110719571.

MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis

Srishti Srivastava, Hima Makala, Vikas Sharma, Vaishali Suri, Chitra Sarkar, Ritu Kulshreshtha

Cell Mol Life Sci. 2022 Feb; 79(2): 104. Published online 2022 Jan 29. doi: 10.1007/s00018-021-04056-6

PMCID:: PMC11071957

Abstract Article PDF–14M

Select item 109424672.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 109332673.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108162844.

The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium

Tsai-Der Chuang, Nhu Ton, Shawn Rysling, Drake Boos, Omid Khorram

Int J Mol Sci. 2024 Jan; 25(2): 1307. Published online 2024 Jan 21. doi: 10.3390/ijms25021307

PMCID:: PMC10816284

Abstract Article PDF–12M

Select item 107340895.

Novel pathogenic variant in MED12 causing non-syndromic dilated cardiomyopathy

Serwa Ghasemi, Mohammad Mahdavi, Majid Maleki, Iman Salahshourifar, Samira Kalayinia

BMC Med Genomics. 2023; 16: 334. Published online 2023 Dec 21. doi: 10.1186/s12920-023-01780-9

PMCID:: PMC10734089

Abstract Article PDF–1.9M

Select item 105658766.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100925568.

Missense MED12 variants in 22 males with intellectual disability: From nonspecific symptoms to complete syndromes

Nuno Maia, Nekane Ibarluzea, Mala Misra‐Isrie, Daniel C. Koboldt, Isabel Marques, Gabriela Soares, Rosário Santos, Carlo L. M. Marcelis, Riikka Keski‐Filppula, Miriam Guitart, Elisabeth Gabau Vila, April Lehman, Scott Hickey, Mari Mori, Paulien Terhal, Irene Valenzuela, Amaia Lasa‐Aranzasti, Anna Maria Cueto‐González, Brian H. Chhouk, Rebecca C. Yeh, Jennifer E. Neil, Bassam Abu‐Libde, Tjitske Kleefstra, Mariet W. Elting, Andrea Császár, Judit Kárteszi, Beáta Bessenyei, Hans van Bokhoven, Paula Jorge, Johanna M. van Hagen, Arjan P. M. de Brouwer

Am J Med Genet A. 2023 Jan; 191(1): 135–143. Published online 2022 Oct 22. doi: 10.1002/ajmg.a.63004

PMCID:: PMC10092556

Abstract Article PDF–1.8M

Select item 99605829.

Differential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas

Tsai-Der Chuang, Jianjun Gao, Derek Quintanilla, Hayden McSwiggin, Drake Boos, Wei Yan, Omid Khorram

Int J Mol Sci. 2023 Feb; 24(4): 3742. Published online 2023 Feb 13. doi: 10.3390/ijms24043742

PMCID:: PMC9960582

Abstract Article PDF–20M

Select item 992246810.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 969968411.

XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation

Farazul Haque, Tasuku Honjo, Nasim A. Begum

Sci Adv. 2022 Nov; 8(47): eadd1466. Published online 2022 Nov 25. doi: 10.1126/sciadv.add1466

PMCID:: PMC9699684

Abstract Article PDF–2.1M

Select item 961818612.

MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer

Yong Zhou, Yuan Tan, Qin Zhang, Qianqian Duan, Jun Chen

Eur J Med Res. 2022; 27: 225. Published online 2022 Oct 29. doi: 10.1186/s40001-022-00856-z

PMCID:: PMC9618186

Abstract Article PDF–1.6M

Select item 934647113.

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation

Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung

EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468

PMCID:: PMC9346471

Abstract Article PDF–5.2M

Select item 934345514.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 926261415.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 920649316.

MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots

Sree Venigalla, Joseph Straub, Onyekachi Idigo, Caroline Rinderle, Jacqueline M. Stephens, Jamie J. Newman

Stem Cells Dev. March 2022; 31(5-6): 119–131. Published online 2022 Mar 14. doi: 10.1089/scd.2021.0302

PMCID:: PMC9206493

Abstract Article PDF–1.0M

Select item 913573917.

Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations

Ryo Maekawa, Shun Sato, Tetsuro Tamehisa, Takahiro Sakai, Takuya Kajimura, Kotaro Sueoka, Norihiro Sugino

Sci Rep. 2022; 12: 8912. Published online 2022 May 26. doi: 10.1038/s41598-022-12899-7

PMCID:: PMC9135739

Abstract Article PDF–7.6M

Select item 911973618.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 902774919.

MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection

Yingchao Zhou, Lingfeng Zha, Jianfei Wu, Mengru Wang, Mengchen Zhou, Gang Wu, Xiang Cheng, Zhengrong Huang, Qiang Xie, Xin Tu

Genes (Basel) 2022 Apr; 13(4): 692. Published online 2022 Apr 14. doi: 10.3390/genes13040692

PMCID:: PMC9027749

Abstract Article PDF–2.9M

Select item 900803920.

Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Sribalasubashini Muralimanoharan, Ross Shamby, Nicholas Stansbury, Robert Schenken, Barbara de la Pena Avalos, Samin Javanmardi, Eloise Dray, Patrick Sung, Thomas G. Boyer

Sci Rep. 2022; 12: 6169. Published online 2022 Apr 13. doi: 10.1038/s41598-022-10188-x

PMCID:: PMC9008039

Abstract Article PDF–4.1M

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