PMC Links for GEO Profiles (Select 74245007) - PMC

Select item 106052241.

Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer

Su-Jeong Kim, Incheol Seo, Min Hee Kim, Joo-Won Park, Shin Kim, Woo-Jae Park

Lipids Health Dis. 2023; 22: 183. Published online 2023 Oct 26. doi: 10.1186/s12944-023-01930-z

PMCID:: PMC10605224

Select item 105335362.

Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer

Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa

Sci Rep. 2023; 13: 16249. Published online 2023 Sep 27. doi: 10.1038/s41598-023-43557-1

PMCID:: PMC10533536

Abstract Article PDF–1.1M

Select item 83529643.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76641205.

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane

Molly M. Hannigan, Alyson M. Hoffman, J. Will Thompson, Tianli Zheng, Christopher V. Nicchitta

Mol Cell Proteomics. 2020 Nov; 19(11): 1826–1849. Published online 2020 Aug 10. doi: 10.1074/mcp.RA120.002228

PMCID:: PMC7664120

Abstract Article PDF–4.8M

Select item 74273276.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 65512668.

FAM105A/OTULINL is a pseudodebuiquitinase of the OTU-class that localizes to the ER membrane

Derek F. Ceccarelli, Sofiia Ivantsiv, Amber Anne Mullin, Etienne Coyaud, Noah Manczyk, Pierre Maisonneuve, Igor Kurinov, Liang Zhao, Chris Go, Anne-Claude Gingras, Brian Raught, Sabine Cordes, Frank Sicheri

Structure. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Structure. 2019 Jun 4; 27(6): 1000–1012.e6. Published online 2019 May 2. doi: 10.1016/j.str.2019.03.022

PMCID:: PMC6551266

Abstract Article PDF–3.4M

Select item 60164659.

Eleven residues determine the acyl chain specificity of ceramide synthases

Rotem Tidhar, Iris D. Zelnik, Giora Volpert, Shifra Ben-Dor, Samuel Kelly, Alfred H. Merrill, Jr., Anthony H. Futerman

J Biol Chem. 2018 Jun 22; 293(25): 9912–9921. Published online 2018 Apr 9. doi: 10.1074/jbc.RA118.001936

PMCID:: PMC6016465

Abstract Article PDF–2.3M

Select item 594022010.

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium

Marcia C. de Oliveira Otto, Rozenn N. Lemaitre, Qi Sun, Irena B. King, Jason H. Y. Wu, Ani Manichaikul, Stephen S. Rich, Michael Y. Tsai, Y. D. Chen, Myriam Fornage, Guan Weihua, Stella Aslibekyan, Marguerite R. Irvin, Edmond K. Kabagambe, Donna K. Arnett, Majken K. Jensen, Barbara McKnight, Bruce M. Psaty, Lyn M. Steffen, Caren E. Smith, Ulf Risérus, Lars Lind, Frank B. Hu, Eric B. Rimm, David S. Siscovick, Dariush Mozaffarian

PLoS One. 2018; 13(5): e0196951. Published online 2018 May 8. doi: 10.1371/journal.pone.0196951

PMCID:: PMC5940220

Abstract Article PDF–1.5M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 481717812.

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Takayuki Sassa, Taisuke Hirayama, Akio Kihara

J Biol Chem. 2016 Apr 1; 291(14): 7477–7487. Published online 2016 Feb 17. doi: 10.1074/jbc.M115.695858

PMCID:: PMC4817178

Abstract Article PDF–1.8M

Select item 427406513.

Genetic loci associated with circulating levels of very long-chain saturated fatty acids

Rozenn N. Lemaitre, Irena B. King, Edmond K. Kabagambe, Jason H. Y. Wu, Barbara McKnight, Ani Manichaikul, Weihua Guan, Qi Sun, Daniel I. Chasman, Millennia Foy, Lu Wang, Jingwen Zhu, David S. Siscovick, Michael Y. Tsai, Donna K. Arnett, Bruce M. Psaty, Luc Djousse, Yii-Der I. Chen, Weihong Tang, Lu-Chen Weng, Hongyu Wu, Majken K. Jensen, Audrey Y. Chu, David R. Jacobs, Jr., Stephen S. Rich, Dariush Mozaffarian, Lyn Steffen, Eric B. Rimm, Frank B. Hu, Paul M. Ridker, Myriam Fornage, Yechiel Friedlander

J Lipid Res. 2015 Jan; 56(1): 176–184. doi: 10.1194/jlr.M052456

PMCID:: PMC4274065

Abstract Article PDF–1.1M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317300015.

Linkage and association of phospholipid transfer protein activity to LASS4

Elisabeth A. Rosenthal, James Ronald, Joseph Rothstein, Ramakrishnan Rajagopalan, Jane Ranchalis, G. Wolfbauer, John J. Albers, John D. Brunzell, Arno G. Motulsky, Mark J. Rieder, Deborah A. Nickerson, Ellen M. Wijsman, Gail P. Jarvik

J Lipid Res. 2011 Oct; 52(10): 1837–1846. doi: 10.1194/jlr.P016576

PMCID:: PMC3173000

Abstract Article PDF–596K

Select item 283669816.

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer

Jianfeng Xu, Siqun Lilly Zheng, Sarah D. Isaacs, Kathleen E. Wiley, Fredrik Wiklund, Jielin Sun, A. Karim Kader, Ge Li, Lina D. Purcell, Seong-Tae Kim, Fang-Chi Hsu, Pär Stattin, Jonas Hugosson, Jan Adolfsson, Patrick C. Walsh, Jeffrey M. Trent, David Duggan, John Carpten, Henrik Grönberg, William B. Isaacs

Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5): 2136–2140. Published online 2010 Jan 11. doi: 10.1073/pnas.0914061107

PMCID:: PMC2836698

Abstract Article PDF–260K

Select item 135612917.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 52892818.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 13924119.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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