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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108769092.

DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis

Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu

Redox Biol. 2024 Apr; 70: 103080. Published online 2024 Feb 8. doi: 10.1016/j.redox.2024.103080

PMCID:: PMC10876909

Abstract Article PDF–18M

Select item 104607113.

Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism

Alena A. Kozlova, Elena Rubets, Magdalini R. Vareltzoglou, Natalia Jarzebska, Vinitha N. Ragavan, Yingjie Chen, Jens Martens-Lobenhoffer, Stefanie M. Bode-Böger, Raul R. Gainetdinov, Roman N. Rodionov, Nadine Bernhardt

J Neural Transm (Vienna) 2023; 130(9): 1097–1112. Published online 2023 Feb 16. doi: 10.1007/s00702-023-02597-7

PMCID:: PMC10460711

Abstract Article PDF–1.4M

Select item 102568014.

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase

Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini, Roman N. Rodionov

Nat Commun. 2023; 14: 3392. Published online 2023 Jun 9. doi: 10.1038/s41467-023-38467-9

PMCID:: PMC10256801

Abstract Article PDF–2.8M

Select item 99080225.

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis

Yizheng Wu, Shuying Shen, Jiaxin Chen, Weiyu Ni, Qinxin Wang, Hongyi Zhou, Junxin Chen, Haitao Zhang, Zixuan Mei, Xuewu Sun, Panyang Shen, Zhiwei Jie, Wenbin Xu, Zhenghua Hong, Yan Ma, Kefan Wang, Shuanglin Wan, Hongfei Wu, Ziang Xie, An Qin, Shunwu Fan

Sci Adv. 2023 Feb; 9(6): eade5584. Published online 2023 Feb 8. doi: 10.1126/sciadv.ade5584

PMCID:: PMC9908022

Abstract Article PDF–1.8M

Select item 96038606.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 95691147.

Dimethylarginine dimethylaminohydrolase 1 protects PM_2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding, Zhongbing Lu

Part Fibre Toxicol. 2022; 19: 64. Published online 2022 Oct 14. doi: 10.1186/s12989-022-00505-7

PMCID:: PMC9569114

Abstract Article PDF–16M

Select item 87487818.

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Ziang Xie, Lei Hou, Shuying Shen, Yizheng Wu, Jian Wang, Zhiwei Jie, Xiangde Zhao, Xiang Li, Xuyang Zhang, Junxin Chen, Wenbin Xu, Lei Ning, Qingliang Ma, Shiyu Wang, Haoming Wang, Putao Yuan, Xiangqian Fang, An Qin, Shunwu Fan

Nat Commun. 2022; 13: 50. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27629-2

PMCID:: PMC8748781

Abstract Article PDF–3.2M

Select item 85211749.

Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1

Ying Wang, Ramcharan Singh Angom, Tanmay A. Kulkarni, Luke H. Hoeppner, Krishnendu Pal, Enfeng Wang, Alexander Tam, Rachael A. Valiunas, Shamit K. Dutta, Baoan Ji, Natalia Jarzebska, Yingjie Chen, Roman N. Rodionov, Debabrata Mukhopadhyay

iScience. 2021 Oct 22; 24(10): 103189. Published online 2021 Sep 30. doi: 10.1016/j.isci.2021.103189

PMCID:: PMC8521174

Abstract Article PDF–3.4M

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 809881411.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 806049512.

Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development

Jingyue Xu, Han Liu, Yu Lan, Rulang Jiang

Front Cell Dev Biol. 2021; 9: 665109. Published online 2021 Apr 8. doi: 10.3389/fcell.2021.665109

PMCID:: PMC8060495

Abstract Article PDF–4.3M

Select item 768936013.

Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Juliane Hannemann, Antonia Glatzel, Jonas Hillig, Julia Zummack, Udo Schumacher, Nicole Lüneburg, Lars Harbaum, Rainer Böger

Front Physiol. 2020; 11: 597559. Published online 2020 Nov 12. doi: 10.3389/fphys.2020.597559

PMCID:: PMC7689360

Abstract Article PDF–2.1M

Select item 708820614.

Genome-wide Identification of Foxf2 Target Genes in Palate Development

J. Xu, H. Liu, Y. Lan, J.S. Park, R. Jiang

J Dent Res. 2020 Apr; 99(4): 463–471. Published online 2020 Feb 10. doi: 10.1177/0022034520904018

PMCID:: PMC7088206

Abstract Article PDF–2.0M

Select item 650263715.

Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction

Xin Xu, Ping Zhang, Dongmin Kwak, John Fassett, Wenhui Yue, Dorothee Atzler, Xinli Hu, Xiaohong Liu, Huan Wang, Zhongbing Lu, Haipeng Guo, Edzard Schwedhelm, Rainer H. Böger, Peijie Chen, Yingjie Chen

Basic Res Cardiol. Author manuscript; available in PMC 2019 May 6.

Published in final edited form as: Basic Res Cardiol. 2017 Aug 17; 112(5): 55. Published online 2017 Aug 17. doi: 10.1007/s00395-017-0644-z

PMCID:: PMC6502637

Abstract Article PDF–1.3M

Select item 645951016.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 608778717.

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1

Tracy Bell, Magali Araujo, Zaiming Luo, James Tomlinson, James Leiper, William J. Welch, Christopher S. Wilcox

Am J Physiol Renal Physiol. 2018 Jul 1; 315(1): F74–F78. Published online 2018 Mar 7. doi: 10.1152/ajprenal.00560.2017

PMCID:: PMC6087787

Abstract Article

Select item 491201018.

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

Clemens Lange, Freya Mowat, Haroon Sayed, Manjit Mehad, Lucie Duluc, Sophie Piper, Ulrich Luhmann, Manasi Nandi, Peter Kelly, Alexander Smith, Robin Ali, James Leiper, James Bainbridge

Exp Eye Res. 2016 Jun; 147: 148–155. doi: 10.1016/j.exer.2016.05.007

PMCID:: PMC4912010

Abstract Article PDF–2.5M

Select item 401357919.

Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass

Johannes Jacobi, Renke Maas, Michaela Arend, Nada Cordasic, Karl F. Hilgers

Int J Mol Sci. 2014 Apr; 15(4): 5522–5535. Published online 2014 Mar 31. doi: 10.3390/ijms15045522

PMCID:: PMC4013579

Abstract Article PDF–551K

Select item 389486020.

Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma

Kayla G. Kinker, Aaron M. Gibson, Stacey A. Bass, Brandy P. Day, Jingyuan Deng, Mario Medvedovic, Julio A. Landero Figueroa, Gurjit K. Khurana Hershey, Weiguo Chen

PLoS One. 2014; 9(1): e85148. Published online 2014 Jan 10. doi: 10.1371/journal.pone.0085148

PMCID:: PMC3894860

Abstract Article PDF–1.4M

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