PMC Links for GEO Profiles (Select 74663363) - PMC

Select item 94360061.

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Ingmar Mederacke, Aveline Filliol, Silvia Affo, Ajay Nair, Celine Hernandez, Qiuyan Sun, Florian Hamberger, Francesco Brundu, Yu Chen, Aashreya Ravichandra, Peter Huebener, Helena Anke, Hongxue Shi, Raquel A. Martínez García de la Torre, James R. Smith, Neil C. Henderson, Florian W. R. Vondran, Carla V. Rothlin, Heike Baehre, Ira Tabas, Pau Sancho-Bru, Robert F. Schwabe

Sci Transl Med. Author manuscript; available in PMC 2022 Oct 6.

Published in final edited form as: Sci Transl Med. 2022 Apr 6; 14(639): eabe5795. Published online 2022 Apr 6. doi: 10.1126/scitranslmed.abe5795

PMCID:: PMC9436006

Abstract Article PDF–2.7M

Select item 88970222.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 86535073.

Characterization of the UDP-glucose receptor (re-named here the P2Y₁₄ receptor) adds diversity to the P2Y receptor family

Maria P. Abbracchio, Jean-Marie Boeynaems, Eric A. Barnard, José L. Boyer, Charles Kennedy, Maria Teresa Miras-Portugal, Brian F. King, Christian Gachet, Kenneth A. Jacobson, Gary A. Weisman, Geoffrey Burnstock

Trends Pharmacol Sci. Author manuscript; available in PMC 2021 Dec 8.

Published in final edited form as: Trends Pharmacol Sci. 2003 Feb; 24(2): 52–55. doi: 10.1016/S0165-6147(02)00038-X

PMCID:: PMC8653507

Abstract Article PDF–482K

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78775125.

P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo‐inflammation

Lyvia Lintzmaier Petiz, Talita Glaser, Julio Scharfstein, Mariusz Z. Ratajczak, Henning Ulrich

Stem Cell Rev Rep. 2021; 17(1): 241–252. Published online 2021 Feb 11. doi: 10.1007/s12015-021-10129-7

PMCID:: PMC7877512

Abstract Article PDF–1.3M

Select item 57093226.

Empowering human cardiac progenitor cells by P2Y₁₄ nucleotide receptor overexpression

Farid G. Khalafalla, Waqas Kayani, Arwa Kassab, Kelli Ilves, Megan M. Monsanto, Roberto Alvarez, Jr, Monica Chavarria, Benjamin Norman, Walter P. Dembitsky, Mark A. Sussman

J Physiol. 2017 Dec 1; 595(23): 7135–7148. Published online 2017 Nov 9. doi: 10.1113/JP274980

PMCID:: PMC5709322

Abstract Article PDF–1.0M

Select item 55316117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 53424838.

Nucleoside 5′-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation

Edyta Gendaszewska-Darmach, Edyta Węgłowska, Aurelia Walczak-Drzewiecka, Kaja Karaś

Oncotarget. 2016 Oct 25; 7(43): 69358–69370. Published online 2016 Oct 9. doi: 10.18632/oncotarget.12541

PMCID:: PMC5342483

Abstract Article PDF–1.0M

Select item 46172119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 414027310.

Extracellular UDP-Glucose Activates P2Y₁₄ Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr⁷⁰⁵ Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

Tiina A. Jokela, Riikka Kärnä, Katri M. Makkonen, Jarmo T. Laitinen, Raija H. Tammi, Markku I. Tammi

J Biol Chem. 2014 Jun 27; 289(26): 18569–18581. Published online 2014 May 20. doi: 10.1074/jbc.M114.551804

PMCID:: PMC4140273

Abstract Article PDF–1.6M

Select item 368482811.

A Selective High-Affinity Antagonist of the P2Y₁₄ Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils

Matthew O. Barrett, Juliana I. Sesma, Christopher B. Ball, P. Suresh Jayasekara, Kenneth A. Jacobson, Eduardo R. Lazarowski, T. Kendall Harden

Mol Pharmacol. 2013 Jul; 84(1): 41–49. Published online 2013 Jul. doi: 10.1124/mol.113.085654

PMCID:: PMC3684828

Abstract Article PDF–609K

Select item 358276912.

CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression

Dong Young Kim, Eunju Kwon, Paul D. Hartley, David C. Crosby, Sumanjit Mann, Nevan J. Krogan, John D. Gross

Mol Cell. Author manuscript; available in PMC 2014 Feb 21.

Published in final edited form as: Mol Cell. 2013 Feb 21; 49(4): 632–644. Published online 2013 Jan 17. doi: 10.1016/j.molcel.2012.12.012

PMCID:: PMC3582769

Abstract Article PDF–4.5M

Select item 346834713.

The UDP-sugar-sensing P2Y₁₄ receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils

Juliana I. Sesma, Silvia M. Kreda, Natacha Steinckwich-Besancon, Hong Dang, Rafael García-Mata, T. Kendall Harden, Eduardo R. Lazarowski

Am J Physiol Cell Physiol. 2012 Sep 1; 303(5): C490–C498. Published online 2012 Jun 6. doi: 10.1152/ajpcell.00138.2012

PMCID:: PMC3468347

Abstract Article

Select item 343155814.

Architecture of P2Y Nucleotide Receptors: Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling

Stefano Costanzi, Liaman Mamedova, Zhan-Guo Gao, Kenneth A. Jacobson

J Med Chem. Author manuscript; available in PMC 2012 Aug 31.

Published in final edited form as: J Med Chem. 2004 Oct 21; 47(22): 5393–5404. doi: 10.1021/jm049914c

PMCID:: PMC3431558

Abstract Article PDF–3.2M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 182107416.

Molecular Dynamics Simulation of the P2Y₁₄ Receptor. Ligand Docking and Identification of a Putative Binding Site of the Distal Hexose Moiety

Andrei A. Ivanov, Ingrid Fricks, T. Kendall Harden, Kenneth A. Jacobson

Bioorg Med Chem Lett. Author manuscript; available in PMC 2008 Feb 1.

Published in final edited form as: Bioorg Med Chem Lett. 2007 Feb 1; 17(3): 761–766. Published online 2006 Oct 28. doi: 10.1016/j.bmcl.2006.10.081

PMCID:: PMC1821074

Abstract Article PDF–1.1M

Select item 122605417.

Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3

Tarja Joensuu, Riikka Hämäläinen, Bo Yuan, Cheryl Johnson, Saara Tegelberg, Paolo Gasparini, Leopoldo Zelante, Ulla Pirvola, Leenamaija Pakarinen, Anna-Elina Lehesjoki, Albert de la Chapelle, Eeva-Marja Sankila

Am J Hum Genet. 2001 Oct; 69(4): 673–684. Published online 2001 Aug 27. doi: 10.1086/323610

Correction in:: Am J Hum Genet. 2001 Nov; 69(5): 1160.

PMCID:: PMC1226054

Abstract Article PDF–645K

Select item 52892818.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 19613219.

P2Y-like receptor, GPR105 (P2Y₁₄), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells

Byeong-Chel Lee, Tao Cheng, Gregor B. Adams, Eyal C. Attar, Nobuyuki Miura, Sean Bong Lee, Yoriko Saito, Ivona Olszak, David Dombkowski, Douglas P. Olson, Julie Hancock, Peter S. Choi, Daniel A. Haber, Andrew D. Luster, David T. Scadden

Genes Dev. 2003 Jul 1; 17(13): 1592–1604. doi: 10.1101/gad.1071503

PMCID:: PMC196132

Abstract Article PDF–843K

Select item 13924120.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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