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Select item 111320511.

The Dual Role of the NFATc2/galectin‐9 Axis in Modulating Tumor‐Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma

Zhi‐Jie Xiao, Si‐Qi Wang, Jun‐Jiang Chen, Yun Li, Yuchen Jiang, Vicky Pui‐Chi Tin, Jia Liu, Huiyi Hu, Maria Pik Wong, Yihang Pan, Judy Wai Ping Yam

Adv Sci (Weinh) 2024 May; 11(20): 2306059. Published online 2024 Mar 25. doi: 10.1002/advs.202306059

PMCID:: PMC11132051

Abstract Article PDF–8.1M

Select item 109178142.

The RNA m⁶A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer

Lichen Ge, Yalan Rui, Cheng Wang, Yingmin Wu, Hongsheng Wang, Junjun Wang

Cell Death Dis. 2024 Mar; 15(3): 192. Published online 2024 Mar 6. doi: 10.1038/s41419-024-06566-0

PMCID:: PMC10917814

Abstract Article PDF–13M

Select item 108019363.

Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma

Lili Liu, Lan Li, Yi Ding, Fangzhou Kong, Wenfa Mo, Hongtao Ye, Danhua Shen

Diagn Pathol. 2024; 19: 19. Published online 2024 Jan 22. doi: 10.1186/s13000-024-01443-y

PMCID:: PMC10801936

Abstract Article PDF–2.3M

Select item 106877274.

Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells

MANUELA MALSY, BERNHARD GRAF, ELISABETH BRUENDL, CONSTANTIN MAIER-STOCKER, ANIKA BUNDSCHERER

Cancer Genomics Proteomics. 2023 Nov-Dec; 20(6 Suppl): 706–711. Published online 2023 Nov 3. doi: 10.21873/cgp.20417

PMCID:: PMC10687727

Abstract Article PDF–847K

Select item 106171975.

NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells

Ju A Shim, So Min Lee, Jin Woo Jeong, Hyori Kim, Woo Jae Son, Jun Hong Park, Parkyong Song, Sin-Hyeog Im, Sangsu Bae, Jung-Hyun Park, Yuna Jo, Changwan Hong

Cell Commun Signal. 2023; 21: 309. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01326-7

PMCID:: PMC10617197

Abstract Article PDF–5.1M

Select item 95865676.

Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice

Li Ni, Satadru K Lahiri, Jiali Nie, Xiaolu Pan, Issam Abu-Taha, Julia O Reynolds, Hannah M Campbell, Haihao Wang, Markus Kamler, Wilhelm Schmitz, Frank Ulrich Müller, Na Li, Xiang Wei, Dao Wen Wang, Dobromir Dobrev, Xander H T Wehrens

Cardiovasc Res. 2022 Sep; 118(13): 2805–2818. Published online 2021 Oct 14. doi: 10.1093/cvr/cvab325

PMCID:: PMC9586567

Abstract Article PDF–1.6M

Select item 85981117.

Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst

Sheena L.M. Ong, Suk Wai Lam, Brendy E.W.M. van den Akker, Herman M. Kroon, Inge H. Briaire-de Bruijn, Arjen H.G. Cleven, Dilara C. Savci-Heijink, Anne-Marie Cleton-Jansen, Daniel Baumhoer, Karoly Szuhai, Judith V.M.G. Bovée

Am J Surg Pathol. 2021 Dec; 45(12): 1669–1681. Published online 2021 Jun 3. doi: 10.1097/PAS.0000000000001748

PMCID:: PMC8598111

Abstract Article PDF–1.0M

Select item 85535698.

Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation

Shane P. Simonett, Sunyoung Shin, Jacob A. Herring, Rhonda Bacher, Linsin A. Smith, Chenyang Dong, Mary E. Rabaglia, Donnie S. Stapleton, Kathryn L. Schueler, Jeea Choi, Matthew N. Bernstein, Daniel R. Turkewitz, Carlos Perez-Cervantes, Jason Spaeth, Roland Stein, Jeffery S. Tessem, Christina Kendziorski, Sündüz Keleş, Ivan P. Moskowitz, Mark P. Keller, Alan D. Attie

J Clin Invest. 2021 Nov 1; 131(21): e144833. Published online 2021 Nov 1. doi: 10.1172/JCI144833

PMCID:: PMC8553569

Abstract Article PDF–2.7M

Select item 84789409.

Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis

Seyedeh Zahra Hosseini Imani, Zohreh Hojati, Sheyda Khalilian, Fariba Dehghanian, Majid Kheirollahi, Mehdi Khorrami, Vahid Shaygannejad, Omid Mirmosayyeb

Sci Rep. 2021; 11: 19260. Published online 2021 Sep 28. doi: 10.1038/s41598-021-98691-5

PMCID:: PMC8478940

Abstract Article PDF–1.7M

Select item 812679410.

The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca²⁺ entry

Pulak Kar, Yu-Ping Lin, Rajesh Bhardwaj, Charles J. Tucker, Gary S. Bird, Matthias A. Hediger, Carina Monico, Nader Amin, Anant B. Parekh

Proc Natl Acad Sci U S A. 2021 May 11; 118(19): e2012908118. Published online 2021 May 3. doi: 10.1073/pnas.2012908118

PMCID:: PMC8126794

Abstract Article PDF–2.0M

Select item 810445211.

EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature

Jarish N. Cohen, Amit J. Sabnis, Gregor Krings, Soo-Jin Cho, Andrew E. Horvai, Jessica L. Davis

Hum Pathol. Author manuscript; available in PMC 2021 May 7.

Published in final edited form as: Hum Pathol. 2018 Nov; 81: 281–290. Published online 2018 Apr 4. doi: 10.1016/j.humpath.2018.03.020

PMCID:: PMC8104452

Abstract Article PDF–1.8M

Select item 800904812.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 797830113.

FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells

Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Rong Xin, Lu Jiang, Juan Lei, Jiangang Zhang, Yu Chen, Jin Peng, Qian Chen, Shuai Yang, Kun Yu, Dingshan Li, Qichao Xie, Yongsheng Li

Theranostics. 2021; 11(10): 5045–5060. Published online 2021 Mar 5. doi: 10.7150/thno.56369

PMCID:: PMC7978301

Abstract Article PDF–2.7M

Select item 787251514.

Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells

Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon, Kyungho Choi, Je-Min Choi, Seong Wook Kang, Won-Woo Lee

eLife. 2021; 10: e61841. Published online 2021 Jan 28. doi: 10.7554/eLife.61841

PMCID:: PMC7872515

Abstract Article PDF–4.8M

Select item 765439615.

Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto

Immun Inflamm Dis. 2020 Dec; 8(4): 704–712. Published online 2020 Oct 20. doi: 10.1002/iid3.360

PMCID:: PMC7654396

Abstract Article PDF–934K

Select item 760751516.

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma

Christian Koelsche, Mark Kriegsmann, Felix K.F. Kommoss, Damian Stichel, Katharina Kriegsmann, Christian Vokuhl, Thomas G.P. Grünewald, Laura Romero-Pérez, Thomas Kirchner, Enrique de Alava, Juan Diaz-Martin, Wolfgang Hartmann, Daniel Baumhoer, Cristina R. Antonescu, Karoly Szuhai, Uta Flucke, Uta Dirksen, Stefan M. Pfister, David T.W. Jones, Gunhild Mechtersheimer, Andreas von Deimling

J Cancer Res Clin Oncol. Author manuscript; available in PMC 2020 Nov 3.

Published in final edited form as: J Cancer Res Clin Oncol. 2019 May; 145(5): 1273–1281. Published online 2019 Mar 20. doi: 10.1007/s00432-019-02895-2

PMCID:: PMC7607515

Abstract Article PDF–1.3M

Select item 752984217.

NUCLEAR FACTOR OF ACTIVATED T CELLS 1 AND 2 ARE REQUIRED FOR VERTEBRAL HOMEOSTASIS

Ernesto Canalis, Lauren Schilling, Tabitha Eller, Jungeun Yu

J Cell Physiol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Cell Physiol. 2020 Nov; 235(11): 8520–8532. Published online 2020 Apr 24. doi: 10.1002/jcp.29696

PMCID:: PMC7529842

Abstract Article PDF–2.2M

Select item 736820018.

STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca²⁺ entry with NFAT1 activation

Ga-Yeon Son, Krishna Prasad Subedi, Hwei Ling Ong, Lucile Noyer, Hassan Saadi, Changyu Zheng, Rajesh Bhardwaj, Stefan Feske, Indu Suresh Ambudkar

Proc Natl Acad Sci U S A. 2020 Jul 14; 117(28): 16638–16648. Published online 2020 Jun 29. doi: 10.1073/pnas.1915386117

PMCID:: PMC7368200

Abstract Article PDF–2.1M

Select item 692775419.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 675606020.

An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells

Valentina Perotti, Paola Baldassari, Alessandra Molla, Gabriella Nicolini, Ilaria Bersani, Giulia Grazia, Fabio Benigni, Andrea Maurichi, Mario Santinami, Andrea Anichini, Roberta Mortarini

Oncogene. 2019; 38(22): 4384–4396. Published online 2019 Feb 1. doi: 10.1038/s41388-019-0729-2

PMCID:: PMC6756060

Abstract Article PDF–2.3M

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