PMC Links for GEO Profiles (Select 74685215) - PMC

Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77052992.

Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2

Valerie Chen, Antonio E. Bruno, Laura L. Britt, Ciria C. Hernandez, Luis E. Gimenez, Alys Peisley, Roger D. Cone, Glenn L. Millhauser

J Biol Chem. 2020 Nov 27; 295(48): 16370–16379. Published online 2020 Sep 17. doi: 10.1074/jbc.RA120.015482

PMCID:: PMC7705299

Abstract Article PDF–2.3M

Select item 72918263.

The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a

Alix A. J. Rouault, Luciana K. Rosselli-Murai, Ciria C. Hernandez, Luis E. Gimenez, Gregory G. Tall, Julien A. Sebag

Sci Signal. Author manuscript; available in PMC 2020 Jul 7.

Published in final edited form as: Sci Signal. 2020 Jan 7; 13(613): eaax4569. Published online 2020 Jan 7. doi: 10.1126/scisignal.aax4569

PMCID:: PMC7291826

Abstract Article PDF–2.1M

Select item 71699834.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 68588785.

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

Morgane Baron, Julie Maillet, Marlène Huyvaert, Aurélie Dechaume, Raphaël Boutry, Hélène Loiselle, Emmanuelle Durand, Bénédicte Toussaint, Emmanuel Vaillant, Julien Philippe, Jérémy Thomas, Amjad Ghulam, Sylvia Franc, Guillaume Charpentier, Jean-Michel Borys, Claire Lévy-Marchal, Maïthé Tauber, Raphaël Scharfmann, Jacques Weill, Cécile Aubert, Julie Kerr-Conte, François Pattou, Ronan Roussel, Beverley Balkau, Michel Marre, Mathilde Boissel, Mehdi Derhourhi, Stefan Gaget, Mickaël Canouil, Philippe Froguel, Amélie Bonnefond

Nat Med. Author manuscript; available in PMC 2020 May 7.

Published in final edited form as: Nat Med. 2019 Sep 28; 25(11): 1733–1738. Published online 2019 Nov 7. doi: 10.1038/s41591-019-0622-0

PMCID:: PMC6858878

Abstract Article PDF–1.9M

Select item 55316116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 53717307.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 46479418.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 46074519.

hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation

Emma I. Kay, Rikus Botha, Johanna M. Montgomery, Kathleen G. Mountjoy

PLoS One. 2015; 10(10): e0140320. Published online 2015 Oct 15. doi: 10.1371/journal.pone.0140320

PMCID:: PMC4607451

Abstract Article PDF–12M

Select item 415423710.

Melanocortin 3 Receptor Has a 5′ Exon That Directs Translation of Apically Localized Protein From the Second In-Frame ATG

Jeenah Park, Neeraj Sharma, Garry R. Cutting

Mol Endocrinol. 2014 Sep; 28(9): 1547–1557. Published online 2014 Jul 22. doi: 10.1210/me.2014-1105

PMCID:: PMC4154237

Abstract Article

Select item 378868811.

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

Masato Asai, Shwetha Ramachandrappa, Maria Joachim, Yuan Shen, Rong Zhang, Nikhil Nuthalapati, Visali Ramanathan, David E. Strochlic, Peter Ferket, Kirsten Linhart, Caroline Ho, Tatiana V. Novoselova, Sumedha Garg, Martin Ridderstråle, Claude Marcus, Joel N. Hirschhorn, Julia M. Keogh, Stephen O’Rahilly, Li F. Chan, Adrian J. Clark, I. Sadaf Farooqi, Joseph A. Majzoub

Science. Author manuscript; available in PMC 2013 Oct 2.

Published in final edited form as: Science. 2013 Jul 19; 341(6143): 275–278. doi: 10.1126/science.1233000

Correction in:: volume 341 on page 959

PMCID:: PMC3788688

Abstract Article PDF–1.5M

Select item 319082612.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311109414.

Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland

Rebecca J Gorrigan, Leonardo Guasti, Peter King, Adrian J Clark, Li F Chan

J Mol Endocrinol. 2011 Jun; 46(3): 227–232. Prepublished online 2011 Mar 2. doi: 10.1530/JME-11-0011

PMCID:: PMC3111094

Abstract Article PDF–224K

Select item 299281015.

Regulation of G Protein–Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2

Julien A. Sebag, Patricia M. Hinkle

Sci Signal. Author manuscript; available in PMC 2010 Nov 28.

Published in final edited form as: Sci Signal. 2010 Apr 6; 3(116): ra28. Published online 2010 Apr 6. doi: 10.1126/scisignal.2000593

PMCID:: PMC2992810

Abstract Article PDF–764K

Select item 266184616.

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

Li F. Chan, Tom R. Webb, Teng-Teng Chung, Eirini Meimaridou, Sadani N. Cooray, Leonardo Guasti, J. Paul Chapple, Michaela Egertová, Maurice R. Elphick, Michael E. Cheetham, Louise A. Metherell, Adrian J. L. Clark

Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15): 6146–6151. Published online 2009 Mar 27. doi: 10.1073/pnas.0809918106