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Items: 1 to 20 of 80

1.
Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt
Phillip A Erice, Xinyan Huang, Matthew J Seasock, Matthew J Robertson, Hui-Ying Tung, Melissa A Perez-Negron, Shivani L Lotlikar, David B Corry, Farrah Kheradmand, Antony Rodriguez
eLife. 2024; 13: RP92879. Published online 2024 May 9. doi: 10.7554/eLife.92879
PMCID:
PMC11081633
AbstractArticlePDF–2.8M
2.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
3.
USP19 suppresses Th17-driven pathogenesis in autoimmunity
Jing Zhang, Ronald J Bouch, Maxim G Blekhman, Zhiheng He
J Immunol. Author manuscript; available in PMC 2022 Jul 1.
Published in final edited form as: J Immunol. 2021 Jul 1; 207(1): 23–33. Published online 2021 Jun 16. doi: 10.4049/jimmunol.2100205
PMCID:
PMC8674369
AbstractArticlePDF–2.1M
4.
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Augustine Fert, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Katarzyna Karwacz, Sally Oxenford, Jean-Pierre Routy, David Irlbeck, Heather Amrine-Madsen, Petronela Ancuta, Ariberto Fassati
Proc Natl Acad Sci U S A. 2021 Nov 30; 118(48): e2105927118. Published online 2021 Nov 24. doi: 10.1073/pnas.2105927118
PMCID:
PMC8640723
AbstractArticlePDF–2.1M
5.
Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement
Timothy S. Strutzenberg, Yingmin Zhu, Scott J. Novick, Ruben D. Garcia-Ordonez, Christelle Doebelin, Yuanjun He, Mi Ra Chang, Theodore M. Kamenecka, Dean P. Edwards, Patrick R. Griffin
J Mol Biol. Author manuscript; available in PMC 2022 Nov 5.
Published in final edited form as: J Mol Biol. 2021 Nov 5; 433(22): 167258. Published online 2021 Sep 20. doi: 10.1016/j.jmb.2021.167258
PMCID:
PMC8556364
AbstractArticlePDF–1.5M
6.
Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells
Paul A. Wilson, Sara Santos Franco, Liu He, Nicholas W. Galwey, Jackie Meakin, Rebecca McIntyre, Simon M. McHugh, Michael A. Nolan, Sarah L. Spain, Thaddeus Carlson, Mercedes Lobera, Justin P. Rubio, Bill Davis, Linda C. McCarthy
PLoS One. 2021; 16(10): e0258316. Published online 2021 Oct 21. doi: 10.1371/journal.pone.0258316
PMCID:
PMC8530322
AbstractArticlePDF–1.7M
7.
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child
Masato Ogishi, Rui Yang, Caner Aytekin, David Langlais, Mathieu Bourgey, Taushif Khan, Fatima Al Ali, Mahbuba Rahman, Ottavia M. Delmonte, Maya Chrabieh, Peng Zhang, Conor Gruber, Simon J. Pelham, András N. Spaan, Jérémie Rosain, Wei-Te Lei, Scott Drutman, Matthew D. Hellmann, Margaret K. Callahan, Matthew Adamow, Phillip Wong, Jedd D. Wolchok, Geetha Rao, Cindy S. Ma, Yuka Nakajima, Tomonori Yaguchi, Kenji Chamoto, Samuel C. Williams, Jean-Francois Emile, Flore Rozenberg, Michael S. Glickman, Franck Rapaport, Gaspard Kerner, Garrett Allington, Ilhan Tezcan, Deniz Cagdas, Ferda O. Hosnut, Figen Dogu, Aydan Ikinciogullari, V. Koneti Rao, Leena Kainulainen, Vivien Béziat, Jacinta Bustamante, Silvia Vilarinho, Richard P. Lifton, Bertrand Boisson, Laurent Abel, Dusan Bogunovic, Nico Marr, Luigi D. Notarangelo, Stuart G. Tangye, Tasuku Honjo, Philippe Gros, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova
Nat Med. Author manuscript; available in PMC 2022 Mar 1.
Published in final edited form as: Nat Med. 2021 Sep; 27(9): 1646–1654. Published online 2021 Jun 28. doi: 10.1038/s41591-021-01388-5
PMCID:
PMC8446316
AbstractArticlePDF–6.4M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt
Rens M. J. M. de Vries, Femke A. Meijer, Richard G. Doveston, Iris A. Leijten-van de Gevel, Luc Brunsveld
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2021287118. Published online 2021 Feb 3. doi: 10.1073/pnas.2021287118
PMCID:
PMC8017705
AbstractArticlePDF–2.0M
10.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
11.
RORγ Structural Plasticity and Druggability
Mian Huang, Shelby Bolin, Hannah Miller, Ho Leung Ng
Int J Mol Sci. 2020 Aug; 21(15): 5329. Published online 2020 Jul 27. doi: 10.3390/ijms21155329
PMCID:
PMC7432406
AbstractArticlePDF–5.7M
12.
Ahr-Foxp3-RORγt Axis Controls Gut Homing of CD4+ T Cells by Regulating GPR15
Lifeng Xiong, Joseph W. Dean, Zheng Fu, Kristen N. Oliff, John W. Bostick, Jian Ye, Zongming E. Chen, Marcus Mühlbauer, Liang Zhou
Sci Immunol. Author manuscript; available in PMC 2020 Dec 12.
Published in final edited form as: Sci Immunol. 2020 Jun 12; 5(48): eaaz7277. doi: 10.1126/sciimmunol.aaz7277
PMCID:
PMC7371246
AbstractArticlePDF–3.2M
13.
Lower T Regulatory and Th17 Cell Populations Predicted by RT-PCR-Amplified FOXP3 and RORγt Genes Are Not Rare in Patients With Primary Immunodeficiency Diseases
Wen-I Lee, Jing-Long Huang, Syh-Jae Lin, Kuo-Wei Yeh, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Tang-Her Jaing, Ying-Fan Shih, Chao-Yi Wu
Front Immunol. 2020; 11: 1111. Published online 2020 Jun 25. doi: 10.3389/fimmu.2020.01111
PMCID:
PMC7330141
AbstractArticlePDF–1.5M
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma
Yu Huang, Huasheng Liang, Chuanxiong He, Fang Peng
Biomed Res Int. 2019; 2019: 5407126. Published online 2019 Nov 3. doi: 10.1155/2019/5407126
PMCID:
PMC6874968
AbstractArticlePDF–1.8M
16.
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis
Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino
Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9
PMCID:
PMC6778137
AbstractArticlePDF–7.8M
17.
On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas
Anna A. Brożyna, Wojciech Jóźwicki, Anton M. Jetten, Andrzej T. Slominski
Exp Dermatol. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: Exp Dermatol. 2019 Sep; 28(9): 1036–1043. Published online 2019 Aug 8. doi: 10.1111/exd.14002
PMCID:
PMC6715521
AbstractArticlePDF–2.0M
18.
Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels
Anna Markiewicz, Anna A. Brożyna, Ewa Podgórska, Martyna Elas, Krystyna Urbańska, Anton M. Jetten, Andrzej T. Slominski, Wojciech Jóźwicki, Jolanta Orłowska-Heitzman, Grzegorz Dyduch, Bożena Romanowska-Dixon
Sci Rep. 2019; 9: 9142. Published online 2019 Jun 24. doi: 10.1038/s41598-019-45161-8
PMCID:
PMC6591242
AbstractArticlePDF–2.4M
19.
Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?
Kritika Subramanian, Tim Dierckx, Ricardo Khouri, Soraya Maria Menezes, Huseini Kagdi, Graham P. Taylor, Lourdes Farre, Achilea Bittencourt, Keisuke Kataoka, Seishi Ogawa, Johan Van Weyenbergh
Int J Cancer. 2019 Apr 1; 144(7): 1664–1675. Published online 2018 Dec 18. doi: 10.1002/ijc.31922
PMCID:
PMC6590643
AbstractArticlePDF–934K
20.
HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
eLife. 2019; 8: e47172. Published online 2019 Jun 7. doi: 10.7554/eLife.47172
Correction in:
eLife. 2019; 8: e52847.
PMCID:
PMC6579513
AbstractArticlePDF–4.3M

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