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Select item 110654221.

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

Rita De Gasperi, Laszlo Csernoch, Beatrix Dienes, Monika Gonczi, Jayanta K Chakrabarty, Shahar Goeta, Abdurrahman Aslan, Carlos A Toro, David Karasik, Lewis M Brown, Marco Brotto, Christopher P Cardozo

eLife. 2024; 12: RP89424. Published online 2024 May 2. doi: 10.7554/eLife.89424

PMCID:: PMC11065422

Abstract Article PDF–2.8M

Select item 107693502.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 105757373.

SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling

Dongxue Su, Yuxi Li, Weiji Zhang, Huan Gao, Yao Cheng, Yongqiang Hou, Junhong Li, Yi Ye, Zhangjian Lai, Zhe Li, Haitao Huang, Jiaxin Li, Jinhuan Li, Mengyu Cheng, Cheng Nian, Na Wu, Zhien Zhou, Yunzhi Xing, Yu Zhao, He Liu, Jiayu Tang, Qinghua Chen, Lixin Hong, Wengang Li, Zhihai Peng, Bin Zhao, Randy L. Johnson, Pingguo Liu, Wanjin Hong, Lanfen Chen, Dawang Zhou

J Clin Invest. 2023 Oct 16; 133(20): e168888. Published online 2023 Oct 16. doi: 10.1172/JCI168888

PMCID:: PMC10575737

Abstract Article PDF–11M

Select item 97043574.

NUMB as a Therapeutic Target for Melanoma

Denitsa M. Hristova, Takeshi Fukumoto, Chihiro Takemori, Le Gao, Xia Hua, Joshua X. Wang, Ling Li, Marilda Beqiri, Andrea Watters, Adina Vultur, Yusra Gimie, Vito Rebecca, Anastasia Samarkina, Haruki Jimbo, Chikako Nishigori, Jie Zhang, Chaoran Cheng, Zhi Wei, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Meenhard Herlyn

J Invest Dermatol. Author manuscript; available in PMC 2022 Nov 28.

Published in final edited form as: J Invest Dermatol. 2022 Jul; 142(7): 1882–1892.e5. Published online 2021 Dec 7. doi: 10.1016/j.jid.2021.11.027

PMCID:: PMC9704357

Abstract Article PDF–2.1M

Select item 95814855.

Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models

Marine Lacomme, Sarah C. Hales, Thomas W. Brown, Katarina Stevanovic, Christine Jolicoeur, Jenny Cai, Therence Bois, Melissa Desrosiers, Deniz Dalkara, Michel Cayouette

Sci Adv. 2022 Oct; 8(42): eabm4295. Published online 2022 Oct 19. doi: 10.1126/sciadv.abm4295

PMCID:: PMC9581485

Abstract Article PDF–12M

Select item 92875506.

NUMB facilitates autophagy initiation through targeting SCF^β-TrCP2 complex

Hao Li, Shuangshuang Shu, Miaomiao Zhou, Ying Chen, An Xiao, Yuanyuan Ma, Fengxin Zhu, Zheng Hu, Jing Nie

Cell Death Differ. 2022 Jul; 29(7): 1409–1422. Published online 2022 Jan 11. doi: 10.1038/s41418-022-00930-3

PMCID:: PMC9287550

Abstract Article PDF–4.3M

Select item 92528357.

Numb Promotes Autophagy through p53 Pathway in Acute Kidney Injury Induced by Cisplatin

Ze Liu, Yong Li, Yongmei He, Junjie Wang

Anal Cell Pathol (Amst) 2022; 2022: 8213683. Published online 2022 Jun 27. doi: 10.1155/2022/8213683

PMCID:: PMC9252835

Abstract Article PDF–2.3M

Select item 90276428.

Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk

Zheng Zhan, Ningyang Yuan, Xue You, Kai Meng, Rula Sha, Zhenzhen Wang, Qian Peng, Zhiqin Xie, Ruijiao Chen, Ying Feng

Int J Mol Sci. 2022 Apr; 23(8): 4363. Published online 2022 Apr 14. doi: 10.3390/ijms23084363

PMCID:: PMC9027642

Abstract Article PDF–3.6M

Select item 89352429.

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy

Meng-Ran Li, Chun-Tao Lei, Hui Tang, Xing-Jie Yin, Zhe Hao, Yang Qiu, Ya-Ru Xie, Jie-Yu Zeng, Hua Su, Chun Zhang

Int J Biol Sci. 2022; 18(5): 1896–1911. Published online 2022 Feb 21. doi: 10.7150/ijbs.68977

PMCID:: PMC8935242

Abstract Article PDF–2.9M

Select item 881861210.

Numb is required for optimal contraction of skeletal muscle

Rita De Gasperi, Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du, Zachary Graham, Jiangping Pan, Xin‐hua Liu, Lei Guo, Bin Zhang, Fred Ko, Ashleigh M. Raczkowski, William A. Bauman, Chris N. Goulbourne, Wei Zhao, Marco Brotto, Christopher P. Cardozo

J Cachexia Sarcopenia Muscle. 2022 Feb; 13(1): 454–466. Published online 2022 Jan 9. doi: 10.1002/jcsm.12907

PMCID:: PMC8818612

Abstract Article PDF–24M

Select item 880333811.

Numb and Numblike regulate sarcomere assembly and maintenance

Baolei Wang, Min Yang, Shujuan Li

J Clin Invest. 2022 Feb 1; 132(3): e139420. Published online 2022 Feb 1. doi: 10.1172/JCI139420

Correction in:: J Clin Invest. 2022 Jul 15; 132(14): e162883.

PMCID:: PMC8803338

Abstract Article PDF–12M

Select item 852659112.

Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling

Yuke Shu, Qing Xu, Yahong Xu, Qing Tao, Mingyang Shao, Xiaoyue Cao, Yuwei Chen, Zhenru Wu, Menglin Chen, Yongjie Zhou, Ping Zhou, Yujun Shi, Hong Bu

Cell Death Dis. 2021 Nov; 12(11): 966. Published online 2021 Oct 19. doi: 10.1038/s41419-021-04263-w

PMCID:: PMC8526591

Abstract Article PDF–7.8M

Select item 847113613.

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis

Lianjie Miao, Yangyang Lu, Anika Nusrat, Hala Y. Abdelnasser, Sayantap Datta, Bin Zhou, Robert J. Schwartz, Mingfu Wu

Cells. 2021 Sep; 10(9): 2192. Published online 2021 Aug 25. doi: 10.3390/cells10092192

PMCID:: PMC8471136

Abstract Article PDF–8.0M

Select item 840852914.

Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation

Shu-Ching Huang, Long V. Vu, Faye H. Yu, Dan T. Nguyen, Edward J. Benz, Jr.

J Biol Chem. 2021 Sep; 297(3): 101051. Published online 2021 Aug 6. doi: 10.1016/j.jbc.2021.101051

PMCID:: PMC8408529

Abstract Article PDF–3.7M

Select item 831323915.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 818779216.

Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway

Alessandro Ianni, Michael Hofmann, Poonam Kumari, Shahriar Tarighi, Hamza M Al-Tamari, André Görgens, Bernd Giebel, Hendrik Nolte, Marcus Krüger, Isabelle Salwig, Soni Savai Pullamsetti, Andreas Günther, André Schneider, Thomas Braun

Front Cell Dev Biol. 2021; 9: 639162. Published online 2021 May 26. doi: 10.3389/fcell.2021.639162

PMCID:: PMC8187792

Abstract Article PDF–9.4M

Select item 810206017.

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir

eLife. 2021; 10: e61974. Published online 2021 Apr 26. doi: 10.7554/eLife.61974

PMCID:: PMC8102060

Abstract Article PDF–3.8M

Select item 793877018.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 741599119.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 729999020.

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

Hye Yeon Choi, Hifzur R. Siddique, Mengmei Zheng, Yi Kou, Da-Wei Yeh, Tatsuya Machida, Chia-Lin Chen, Dinesh Babu Uthaya Kumar, Vasu Punj, Peleg Winer, Alejandro Pita, Linda Sher, Stanley M. Tahara, Ratna B. Ray, Chengyu Liang, Lin Chen, Hidekazu Tsukamoto, Keigo Machida

Nat Commun. 2020; 11: 3084. Published online 2020 Jun 17. doi: 10.1038/s41467-020-16616-8

PMCID:: PMC7299990

Abstract Article PDF–4.4M

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