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Select item 100729061.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 96701872.

Alternative splicing of HSPA12A pre‐RNA by SRSF11 contributes to metastasis potential of colorectal cancer

Yao‐Jie Pan, Fu‐Chun Huo, Meng‐Jie Kang, Bo‐Wen Liu, Meng‐Di Wu, Dong‐Sheng Pei

Clin Transl Med. 2022 Nov; 12(11): e1113. Published online 2022 Nov 17. doi: 10.1002/ctm2.1113

PMCID:: PMC9670187

Abstract Article PDF–4.6M

Select item 96266883.

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis

Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu

iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363

PMCID:: PMC9626688

Abstract Article PDF–6.0M

Select item 88864454.

The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer

Hao Zeng, Fan Tong, Yawen Bin, Ling Peng, Xuan Gao, Xuefeng Xia, Xin Yi, Xiaorong Dong

Front Immunol. 2022; 13: 834142. Published online 2022 Feb 3. doi: 10.3389/fimmu.2022.834142

PMCID:: PMC8886445

Abstract Article PDF–2.5M

Select item 84445585.

PAK5‐stabilized Smuc confers renal cell carcinoma metastasis

Fu‐Chun Huo, Zhi‐Man Zhu, Qiu‐Ying Du, Dong‐Sheng Pei

Clin Transl Med. 2021 Sep; 11(9): e559. Published online 2021 Sep 16. doi: 10.1002/ctm2.559

PMCID:: PMC8444558

Article PDF–1.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78623937.

P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer

Ding-Guo Zhang, Chan-Chan Gong, Xiao-Jin Wu, Xin Ren, Randee S. Sedaka, Wei-Cong Chen, Fu-Chun Huo, Cheng Chen, Wen-Qi Du, Dong-Sheng Pei

Signal Transduct Target Ther. 2021; 6: 47. Published online 2021 Feb 5. doi: 10.1038/s41392-020-00409-y

PMCID:: PMC7862393

Article PDF–1.2M

Select item 74273278.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 73396669.

Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma

Xuefeng Wang, Shuang Liu, Zhengkai Shao, Penghai Zhang

Mol Med Rep. 2020 Aug; 22(2): 1362–1372. Published online 2020 Jun 3. doi: 10.3892/mmr.2020.11206

PMCID:: PMC7339666

Abstract Article PDF–1.4M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 674809511.

PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1

Fu-Chun Huo, Yao-Jie Pan, Tong-Tong Li, Jie Mou, Dong-Sheng Pei

Cell Death Differ. 2019 Jun; 26(6): 994–1006. Published online 2018 Aug 6. doi: 10.1038/s41418-018-0178-4

PMCID:: PMC6748095

Abstract Article PDF–7.2M

Select item 674264612.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 613922913.

PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer

Diyou Li, Yinglin Pan, Yating Huang, Ping Zhang, Xuhong Fang

Anal Cell Pathol (Amst) 2018; 2018: 8073124. Published online 2018 Sep 2. doi: 10.1155/2018/8073124

PMCID:: PMC6139229

Abstract Article PDF–5.1M

Select item 568092614.

MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5

Yao-Jie Pan, Lu-Lu Wei, Xiao-Jin Wu, Fu-Chun Huo, Jie Mou, Dong-Sheng Pei

Cell Death Dis. 2017 Oct; 8(10): e3155. Published online 2017 Oct 26. doi: 10.1038/cddis.2017.561

PMCID:: PMC5680926

Abstract Article PDF–4.7M

Select item 564598615.

PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo

Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou, Dong-Sheng Pei

J Exp Clin Cancer Res. 2017; 36: 146. Published online 2017 Oct 17. doi: 10.1186/s13046-017-0610-5

PMCID:: PMC5645986

Abstract Article PDF–6.9M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 521678017.

High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Chao Li, Jian Chen, Yupeng Wang, Guohe Song, Chao Xiao, Dongwang Yan, Lin Zhong, Xing Sun, Xiaoliang Wang, Fudong Yu, Yang Yu, Huamei Tang, Zhihai Peng

Oncotarget. 2016 Jul 19; 7(29): 46042–46055. Published online 2016 Jun 14. doi: 10.18632/oncotarget.10017

Correction in:: Oncotarget. 2017 Jul 4; 8(27): 45031.

PMCID:: PMC5216780

Abstract Article PDF–10M

Select item 499245618.

Mitochondrial protein interaction mapping identifies new regulators of respiratory chain function

Brendan J. Floyd, Emily M. Wilkerson, Mike T. Veling, Catie E. Minogue, Chuanwu Xia, Emily T. Beebe, Russell L. Wrobel, Holly Cho, Laura S. Kremer, Charlotte L. Alston, Katarzyna A. Gromek, Brendan K. Dolan, Arne Ulbrich, Jonathan A. Stefely, Sarah L. Bohl, Kelly M. Werner, Adam Jochem, Michael S. Westphall, Jarred W. Rensvold, Robert W. Taylor, Holger Prokisch, Jung-Ja P. Kim, Joshua J. Coon, David J. Pagliarini

Mol Cell. Author manuscript; available in PMC 2017 Aug 18.

Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 621–632. Published online 2016 Aug 4. doi: 10.1016/j.molcel.2016.06.033

PMCID:: PMC4992456

Abstract Article PDF–1.7M

Select item 484875819.

An inter‐species protein–protein interaction network across vast evolutionary distance

Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, Marc Vidal

Mol Syst Biol. 2016 Apr; 12(4): 865. Published online 2016 Apr 23. doi: 10.15252/msb.20156484

PMCID:: PMC4848758

Abstract Article PDF–2.1M

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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